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View Structure Prediction Details

Protein: FAS2
Organism: Saccharomyces cerevisiae
Length: 1887 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FAS2.

Description E-value Query
Range
Subject
Range
FAS2_CANAX - Fatty acid synthase subunit alpha OS=Candida albicans GN=FAS2 PE=3 SV=1
0.0 [1..1884] [1..1883]
gi|32414229, gi|... - gi|32414229|ref|XP_327594.1| hypothetical protein [Neurospora crassa], gi|28924073|gb|EAA33230.1| fa...
gi|85107908 - gi|85107908|ref|XP_962466.1| fatty acid synthase alpha subunit reductase [Neurospora crassa OR74A]
0.0 [1..1885] [1..1863]
FAS2 - Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty ...
FAS2_YEAST - Fatty acid synthase subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FAS2 P...
0.0 [1..1887] [1..1887]
FAS2_EMEND - Fatty acid synthase subunit alpha OS=Emericella nidulans GN=fasA PE=3 SV=1
0.0 [1..1884] [1..1856]
gi|14701593 - gi|14701593|dbj|BAB62031.1| fatty acid synthase alpha-subunit [Schizosaccharomyces pombe]
0.0 [1..1886] [1..1842]
FAS2_SCHPO - Fatty acid synthase subunit alpha OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=fas2 PE=...
fas2 - fatty acid synthase alpha subunit Lsd1
0.0 [1..1886] [1..1842]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..1886] [1..1842]

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Predicted Domain #1
Region A:
Residues: [1-217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPEVEQELA HILLTELLAY QFASPVRWIE TQDVFLKDFN TERVVEIGPS PTLAGMAQRT  60
   61 LKNKYESYDA ALSLHREILC YSKDAKEIYY TPDPSELAAK EEPAKEEAPA PTPAASAPAP 120
  121 AAAAPAPVAA AAPAAAAAEI ADEPVKASLL LHVLVAHKLK KSLDSIPMSK TIKDLVGGKS 180
  181 TVQNEILGDL GKEFGTTPEK PEETPLEELA ETFQDTF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [218-634]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGALGKQSSS LLSRLISSKM PGGFTITVAR KYLQTRWGLP SGRQDGVLLV ALSNEPAARL  60
   61 GSEADAKAFL DSMAQKYASI VGVDLSSAAS ASGAAGAGAA AGAAMIDAGA LEEITKDHKV 120
  121 LARQQLQVLA RYLKMDLDNG ERKFLKEKDT VAELQAQLDY LNAELGEFFV NGVATSFSRK 180
  181 KARTFDSSWN WAKQSLLSLY FEIIHGVLKN VDREVVSEAI NIMNRSNDAL IKFMEYHISN 240
  241 TDETKGENYQ LVKTLGEQLI ENCKQVLDVD PVYKDVAKPT GPKTAIDKNG NITYSEEPRE 300
  301 KVRKLSQYVQ EMALGGPITK ESQPTIEEDL TRVYKAISAQ ADKQDISSST RVEFEKLYSD 360
  361 LMKFLESSKE IDPSQTTQLA GMDVEDALDK DSTKEVASLP NKSTISKTVS STIPRET

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [635-896]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPFLHLRKKT PAGDWKYDRQ LSSLFLDGLE KAAFNGVTFK DKYVLITGAG KGSIGAEVLQ  60
   61 GLLQGGAKVV VTTSRFSKQV TDYYQSIYAK YGAKGSTLIV VPFNQGSKQD VEALIEFIYD 120
  121 TEKNGGLGWD LDAIIPFAAI PEQGIELEHI DSKSEFAHRI MLTNILRMMG CVKKQKSARG 180
  181 IETRPAQVIL PMSPNHGTFG GDGMYSESKL SLETLFNRWH SESWANQLTV CGAIIGWTRG 240
  241 TGLMSANNII AEGIEKMGVR TF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.221849
Match: 1gz6A_
Description: (3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [897-1126]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQKEMAFNLL GLLTPEVVEL CQKSPVMADL NGGLQFVPEL KEFTAKLRKE LVETSEVRKA  60
   61 VSIETALEHK VVNGNSADAA YAQVEIQPRA NIQLDFPELK PYKQVKQIAP AELEGLLDLE 120
  121 RVIVVTGFAE VGPWGSARTR WEMEAFGEFS LEGCVEMAWI MGFISYHNGN LKGRPYTGWV 180
  181 DSKTKEPVDD KDVKAKYETS ILEHSGIRLI EPELFNGYNP EKKEMIQEVI 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1127-1406]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VEEDLEPFEA SKETAEQFKH QHGDKVDIFE IPETGEYSVK LLKGATLYIP KALRFDRLVA  60
   61 GQIPTGWNAK TYGISDDIIS QVDPITLFVL VSVVEAFIAS GITDPYEMYK YVHVSEVGNC 120
  121 SGSGMGGVSA LRGMFKDRFK DEPVQNDILQ ESFINTMSAW VNMLLISSSG PIKTPVGACA 180
  181 TSVESVDIGV ETILSGKARI CIVGGYDDFQ EEGSFEFGNM KATSNTLEEF EHGRTPAEMS 240
  241 RPATTTRNGF MEAQGAGIQI IMQADLALKM GVPIYGIVAM 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1505-1530]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQWGNDFYK RDPRIAPLRG ALATYG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 209.54902
Match: 1e5mA_
Description: Beta-ketoacyl-ACP synthase II
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1407-1504]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AATATDKIGR SVPAPGKGIL TTAREHHSSV KYASPNLNMK YRKRQLVTRE AQIKDWVENE  60
   61 LEALKLEAEE IPSEDQNEFL LERTREIHNE AESQLRAA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1531-1583]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTIDDLGVAS FHGTSTKAND KNESATINEM MKHLGRSEGN PVIGVFQKFL TGH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 209.54902
Match: 1e5mA_
Description: Beta-ketoacyl-ACP synthase II
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1584-1661]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKGAAGAWMM NGALQILNSG IIPGNRNADN VDKILEQFEY VLYPSKTLKT DGVRAVSITS  60
   61 FGFGQKGGQA IVVHPDYL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1662-1751]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YGAITEDRYN EYVAKVSARE KSAYKFFHNG MIYNKLFVSK EHAPYTDELE EDVYLDPLAR  60
   61 VSKDKKSGSL TFNSKNIQSK DSYINANTIE 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1752-1887]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TAKMIENMTK EKVSNGGVGV DVELITSINV ENDTFIERNF TPQEIEYCSA QPSVQSSFAG  60
   61 TWSAKEAVFK SLGVKSLGGG AALKDIEIVR VNKNAPAVEL HGNAKKAAEE AGVTDVKVSI 120
  121 SHDDLQAVAV AVSTKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1f80A_
Description: Holo-(acyl carrier protein) synthase ACPS
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle