YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: NIP100
Organism: Saccharomyces cerevisiae
Length: 868 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NIP100.

Description E-value Query
Range
Subject
Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
0.0 [42..814] [859..1618]
MYH2_HORSE - Myosin-2 OS=Equus caballus GN=MYH2 PE=2 SV=1
0.0 [35..814] [852..1618]
MYH2_BOVIN - Myosin-2 OS=Bos taurus GN=MYH2 PE=2 SV=1
0.0 [35..814] [855..1621]
gi|9800488, gi|1... - gi|9800488|gb|AAF99315.1|AF272034_1 fast myosin heavy chain isoform 3 [Gallus gallus], gi|165973976|...
0.0 [42..850] [862..1656]
gi|42476190, gi|... - gi|42476190|ref|NP_060004.2| myosin, heavy polypeptide 2, skeletal muscle, adult [Homo sapiens], gi|...
0.0 [35..814] [856..1622]

Back

Predicted Domain #1
Region A:
Residues: [1-342]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRNAGVQVDT NMQKISLQDT VLVNEMKGRV KFIGETQFAK GIWYGIELDK PLGKNDGSAN  60
   61 GIRYFDIDLK KANSNGGYYG LFCKKDTLQF YKPDDDEHSL LNGNAAQETI KNLQVKCESL 120
  121 ASKLNKIKIE NHELKTSVEK LSTNETVLLS KISRLDKLVK ELKVENGNMK THLDNFNHLL 180
  181 DASDSVMAPD LDKGTLLERS HLLQGLLDQT KLSYDKAMKV QEDLLEENTQ LLEENAVLSK 240
  241 KISDLGLQLQ QTNNTIGDLA LQIEAQSKSS NIVDKLTNDN ILLTSNIKAL NNELEELQAK 300
  301 EKLDENLRIT YEQLEQELRL QLSNLQSALE NEKEIAGTYI EE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.69897
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [343-445]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSRLKATLES IEAKTSHKFQ SLELKVNTLQ EELYQNKLLK KFYQIYEPFA QPHLAALSSQ  60
   61 LQYLAEVIES ENFGKLENIE IHIILKVLSS ISYALHIYTI KNT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.699 0.026 microtubule binding a.47.2 t-snare proteins
View Download 0.609 0.026 microtubule binding a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.755 0.026 microtubule binding a.24.4 Hemerythrin
View Download 0.801 0.026 microtubule binding a.60.9 lambda integrase-like, N-terminal domain
View Download 0.670 0.026 microtubule binding d.164.1 SMAD MH1 domain
View Download 0.608 0.026 microtubule binding a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.586 0.026 microtubule binding a.29.4 RecG, N-terminal domain
View Download 0.582 0.026 microtubule binding a.24.17 Group V grass pollen allergen
View Download 0.578 0.026 microtubule binding d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.578 0.026 microtubule binding c.55.3 Ribonuclease H-like
View Download 0.572 0.026 microtubule binding a.118.8 TPR-like
View Download 0.570 0.026 microtubule binding a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.564 0.026 microtubule binding a.1.1 Globin-like
View Download 0.561 0.026 microtubule binding a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.551 0.026 microtubule binding a.74.1 Cyclin-like
View Download 0.543 0.026 microtubule binding a.24.9 alpha-catenin/vinculin
View Download 0.541 0.026 microtubule binding a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.539 0.026 microtubule binding a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.537 0.026 microtubule binding a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.537 0.026 microtubule binding a.7.6 Ribosomal protein S20
View Download 0.520 0.026 microtubule binding a.47.2 t-snare proteins
View Download 0.519 0.026 microtubule binding a.29.2 Bromodomain
View Download 0.516 0.026 microtubule binding a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.516 0.026 microtubule binding a.2.2 Ribosomal protein L29 (L29p)
View Download 0.511 0.026 microtubule binding a.118.1 ARM repeat
View Download 0.502 0.026 microtubule binding a.39.1 EF-hand
View Download 0.498 0.026 microtubule binding a.61.1 Retroviral matrix proteins
View Download 0.493 0.026 microtubule binding d.56.1 GroEL-intermediate domain like
View Download 0.489 0.026 microtubule binding a.7.1 Spectrin repeat
View Download 0.484 0.026 microtubule binding a.46.1 Methionine synthase domain
View Download 0.481 0.026 microtubule binding a.85.1 Hemocyanin, N-terminal domain
View Download 0.480 0.026 microtubule binding d.13.1 HIT-like
View Download 0.477 0.026 microtubule binding i.11.1 Computational models partly based on NMR data
View Download 0.475 0.026 microtubule binding a.7.7 BAG domain
View Download 0.471 0.026 microtubule binding a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.464 0.026 microtubule binding a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.461 0.026 microtubule binding a.90.1 Transcription factor STAT-4 N-domain
View Download 0.454 0.026 microtubule binding a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.448 0.026 microtubule binding a.47.2 t-snare proteins
View Download 0.444 0.026 microtubule binding a.24.3 Cytochromes
View Download 0.443 0.026 microtubule binding f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.440 0.026 microtubule binding a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.429 0.026 microtubule binding a.19.1 Fertilization protein
View Download 0.423 0.026 microtubule binding a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.419 0.026 microtubule binding d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.415 0.026 microtubule binding a.7.1 Spectrin repeat
View Download 0.413 0.026 microtubule binding a.4.5 "Winged helix" DNA-binding domain
View Download 0.411 0.026 microtubule binding a.74.1 Cyclin-like
View Download 0.409 0.026 microtubule binding a.74.1 Cyclin-like
View Download 0.399 0.026 microtubule binding a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.391 0.026 microtubule binding a.24.17 Group V grass pollen allergen
View Download 0.389 0.026 microtubule binding a.29.2 Bromodomain
View Download 0.387 0.026 microtubule binding a.133.1 Phospholipase A2, PLA2
View Download 0.385 0.026 microtubule binding c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.382 0.026 microtubule binding a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.379 0.026 microtubule binding a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.377 0.026 microtubule binding a.61.1 Retroviral matrix proteins
View Download 0.376 0.026 microtubule binding a.118.11 Cytochrome c oxidase subunit E
View Download 0.374 0.026 microtubule binding a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.372 0.026 microtubule binding a.74.1 Cyclin-like
View Download 0.372 0.026 microtubule binding a.7.1 Spectrin repeat
View Download 0.371 0.026 microtubule binding d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.366 0.026 microtubule binding a.48.1 N-terminal domain of cbl (N-cbl)
View Download 0.366 0.026 microtubule binding a.22.1 Histone-fold
View Download 0.365 0.026 microtubule binding a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.361 0.026 microtubule binding d.44.1 Fe,Mn superoxide dismutase (SOD), C-terminal domain
View Download 0.361 0.026 microtubule binding a.39.1 EF-hand
View Download 0.360 0.026 microtubule binding a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.360 0.026 microtubule binding a.174.1 Double Clp-N motif
View Download 0.360 0.026 microtubule binding d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.357 0.026 microtubule binding a.81.1 N-terminal domain of DnaB helicase
View Download 0.354 0.026 microtubule binding a.7.8 GAT domain
View Download 0.353 0.026 microtubule binding a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.347 0.026 microtubule binding a.77.1 DEATH domain
View Download 0.347 0.026 microtubule binding a.24.15 FAD-dependent thiol oxidase
View Download 0.346 0.026 microtubule binding a.35.1 lambda repressor-like DNA-binding domains
View Download 0.345 0.026 microtubule binding a.26.1 4-helical cytokines
View Download 0.343 0.026 microtubule binding a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.337 0.026 microtubule binding a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.335 0.026 microtubule binding a.24.15 FAD-dependent thiol oxidase
View Download 0.334 0.026 microtubule binding a.39.1 EF-hand
View Download 0.333 0.026 microtubule binding a.112.1 Description not found.
View Download 0.330 0.026 microtubule binding a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.323 0.026 microtubule binding a.1.1 Globin-like
View Download 0.320 0.026 microtubule binding a.25.1 Ferritin-like
View Download 0.318 0.026 microtubule binding a.158.1 F-box domain
View Download 0.318 0.026 microtubule binding d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.317 0.026 microtubule binding a.1.1 Globin-like
View Download 0.316 0.026 microtubule binding a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.308 0.026 microtubule binding a.23.2 Diol dehydratase, gamma subunit
View Download 0.307 0.026 microtubule binding d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.303 0.026 microtubule binding a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.300 0.026 microtubule binding a.25.1 Ferritin-like
View Download 0.298 0.026 microtubule binding a.1.1 Globin-like
View Download 0.296 0.026 microtubule binding a.130.1 Chorismate mutase II
View Download 0.296 0.026 microtubule binding a.1.1 Globin-like
View Download 0.294 0.026 microtubule binding f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.292 0.026 microtubule binding f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.291 0.026 microtubule binding a.134.1 Fungal elicitin
View Download 0.286 0.026 microtubule binding a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.285 0.026 microtubule binding a.61.1 Retroviral matrix proteins
View Download 0.284 0.026 microtubule binding d.13.1 HIT-like
View Download 0.280 0.026 microtubule binding a.77.1 DEATH domain
View Download 0.278 0.026 microtubule binding a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.274 0.026 microtubule binding e.20.1 Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment
View Download 0.272 0.026 microtubule binding a.3.1 Cytochrome c
View Download 0.270 0.026 microtubule binding a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.270 0.026 microtubule binding a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.268 0.026 microtubule binding f.32.1 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.266 0.026 microtubule binding a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.264 0.026 microtubule binding a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.258 0.026 microtubule binding a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.257 0.026 microtubule binding a.77.1 DEATH domain
View Download 0.256 0.026 microtubule binding a.26.1 4-helical cytokines
View Download 0.255 0.026 microtubule binding d.228.1 Replication modulator SeqA, C-terminal DNA-binding domain
View Download 0.243 0.026 microtubule binding d.42.1 POZ domain
View Download 0.241 0.026 microtubule binding d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.239 0.026 microtubule binding d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.236 0.026 microtubule binding d.195.1 YopH tyrosine phosphatase N-terminal domain
View Download 0.236 0.026 microtubule binding a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.235 0.026 microtubule binding a.63.1 Apolipophorin-III
View Download 0.231 0.026 microtubule binding d.198.1 Type III secretory system chaperone
View Download 0.230 0.026 microtubule binding a.135.1 Tetraspanin
View Download 0.229 0.026 microtubule binding a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.229 0.026 microtubule binding a.24.11 Bacterial GAP domain
View Download 0.227 0.026 microtubule binding a.4.5 "Winged helix" DNA-binding domain
View Download 0.226 0.026 microtubule binding f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.221 0.026 microtubule binding a.30.1 ROP protein
View Download 0.220 0.026 microtubule binding a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.218 0.026 microtubule binding a.39.1 EF-hand
View Download 0.217 0.026 microtubule binding a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.214 0.026 microtubule binding a.74.1 Cyclin-like
View Download 0.210 0.026 microtubule binding c.23.1 CheY-like
View Download 0.209 0.026 microtubule binding a.39.3 Cloroperoxidase
View Download 0.208 0.026 microtubule binding a.24.3 Cytochromes
View Download 0.206 0.026 microtubule binding a.24.3 Cytochromes
View Download 0.205 0.026 microtubule binding a.1.1 Globin-like
View Download 0.205 0.026 microtubule binding a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.205 0.026 microtubule binding d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.203 0.026 microtubule binding a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.202 0.026 microtubule binding a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.201 0.026 microtubule binding a.5.6 Hypothetical protein MTH1615
View Download 0.200 0.026 microtubule binding e.37.1 Bifunctional dehydrogenase/ferrochelatase Met8p, dimerisation and C-terminal domains

Predicted Domain #3
Region A:
Residues: [446-562]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDHLETTLQC FKVNIAPISM WLSEFLQRKF SSKQETAFSI CQFLEDNKFL DKDVTLILKI  60
   61 LHPILETTVP KLLAFLRTNS NFNDNDTLCL IGSLYERSLS LIARIDKLIG KEEISKQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.221849
Match: 1c1gA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [563-790]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNRLFLYPSC DITLSSILTI LFSDALFLRQ DYKRISSLKK LEVFFQGIES LLENITIFPE  60
   61 QPSQQTSDSE SQCNIKEGNF SNSLLSDRLN EENIRLKEVL VQKENMLTEL ETKIKIIIGR 120
  121 DLERKTLEEN IKTLKVELNN KNEENCGKTE ILNKLKEENF NLVNRLKNME LKLYQIKDNN 180
  181 TLNKIYLDRE KVDRVNLVSE IMELRETIRR QIKEQKRVSI DFSWLDEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.221849
Match: 1c1gA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [791-868]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAVENKQPFK EHINHSLDTL GIEMFNFVST SRILDLKLDQ PLAEDELWHE RDHSYISYLK  60
   61 RKRKNIRLKS QNVVTYYK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.474 a.4.5 "Winged helix" DNA-binding domain
View Download 0.576 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.420 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.387 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.353 d.58.25 Killer toxin KP6 alpha-subunit
View Download 0.318 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.309 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.302 a.28.1 ACP-like
View Download 0.298 d.58.17 Metal-binding domain
View Download 0.291 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.289 i.1.1 Ribosome and ribosomal fragments
View Download 0.286 b.4.1 HSP40/DnaJ peptide-binding domain
View Download 0.273 a.77.1 DEATH domain
View Download 0.262 a.5.2 UBA-like
View Download 0.247 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.246 d.58.3 Protease propeptides/inhibitors
View Download 0.237 a.144.1 PABC (PABP) domain
View Download 0.233 a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.233 d.8.1 Urease, gamma-subunit
View Download 0.229 a.46.1 Methionine synthase domain
View Download 0.228 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.222 a.112.1 Description not found.
View Download 0.214 a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.212 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.204 a.4.5 "Winged helix" DNA-binding domain
View Download 0.201 a.60.9 lambda integrase-like, N-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle