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View Structure Prediction Details

Protein: TIM50
Organism: Saccharomyces cerevisiae
Length: 476 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TIM50.

Description E-value Query
Range
Subject
Range
tim50 - TIM23 translocase complex subunit Tim50
TIM50_SCHPO - Mitochondrial import inner membrane translocase subunit tim50 OS=Schizosaccharomyces pombe (strain 9...
381.0 [0..44] [426..31]
TIM50_CANGA - Mitochondrial import inner membrane translocase subunit TIM50 OS=Candida glabrata GN=TIM50 PE=3 SV=1
TIM50_CANGA - Mitochondrial import inner membrane translocase subunit TIM50 OS=Candida glabrata (strain ATCC 2001 ...
379.0 [0..1] [471..1]
TIM50_MOUSE - Mitochondrial import inner membrane translocase subunit TIM50 OS=Mus musculus GN=Timm50 PE=1 SV=1
374.0 [0..79] [394..33]
gi|119577306, gi... - gi|48526509|ref|NP_001001563.1| translocase of inner mitochondrial membrane 50 homolog [Homo sapiens...
371.0 [0..80] [394..137]
gi|114677195 - gi|114677195|ref|XP_001138592.1| PREDICTED: translocase of inner mitochondrial membrane 50 homolog i...
369.0 [0..80] [394..137]
gi|109461526, gi... - gi|149056475|gb|EDM07906.1| rCG54610, isoform CRA_a [Rattus norvegicus], gi|109461526|ref|XP_0010733...
368.0 [0..79] [394..33]

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Predicted Domain #1
Region A:
Residues: [1-156]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSILRNSVR LNSRALRVVP SAANTLTSVQ ASRRLLTSYS SFLQKETKDD KPKSILTDDM  60
   61 LFKAGVDVDE KGQGKNEETS GEGGEDKNEP SSKSEKSRRK RQTSTDIKRE KYANWFYIFS 120
  121 LSALTGTAIY MARDWEPQES EELKKDIDNG YTLSLM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.374 N/A N/A f.1.5 Exotoxin A, middle domain
View Download 0.287 N/A N/A c.52.1 Restriction endonuclease-like
View Download 0.230 N/A N/A a.26.1 4-helical cytokines
View Download 0.219 N/A N/A a.74.1 Cyclin-like
View Download 0.215 N/A N/A b.91.1 E2 regulatory, transactivation domain

Predicted Domain #2
Region A:
Residues: [157-348]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKRFKARFNS MFTYFQEPPF PDLLPPPPPP PYQRPLTLVI TLEDFLVHSE WSQKHGWRTA  60
   61 KRPGADYFLG YLSQYYEIVL FSSNYMMYSD KIAEKLDPIH AFVSYNLFKE HCVYKDGVHI 120
  121 KDLSKLNRDL SKVIIIDTDP NSYKLQPENA IPMEPWNGEA DDKLVRLIPF LEYLATQQTK 180
  181 DVRPILNSFE DK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.221849
Match: 2hhlA
Description: No description for 2hhlA was found.

Predicted Domain #3
Region A:
Residues: [349-476]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNLAEEFDHR VKKLKDKFYG DHKSGGNWAM TALGLGNSLG GSTKFPLDLI HEEGQKNYLM  60
   61 FMKMIEEEKE KIRIQQEQMG GQTFTLKDYV EGNLPSPEEQ MKIQLEKQKE VDALFEEEKK 120
  121 KKKIAESK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.460 a.47.2 t-snare proteins
View Download 0.263 a.59.1 PAH2 domain
View Download 0.258 a.118.1 ARM repeat
View Download 0.257 a.165.1 Myosin phosphatase inhibitor 17kDa protein, CPI-17
View Download 0.247 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle