YRC Public Data Repository - Protein Structure Prediction

Protein:	YOR378W
Organism:	Saccharomyces cerevisiae
Length:	515 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YOR378W.

Description	E-value	Query Range	Subject Range
gi\|27316398, gi\|... - gi\|27468850\|ref\|NP_765487.1\| multidrug resistance protein [Staphylococcus epidermidis ATCC 12228], g...	0.0	[42..495]	[151..634]
lcl\|NC_016856.1_... - [gene=emrB] [protein=putative multidrug transport protein] [protein_id=YP_005238915.1] [location=298... gi\|16766126, gi\|... - gi\|16766126\|ref\|NP_461741.1\| putative multidrug transport protein [Salmonella typhimurium LT2], gi\|1... gi\|167992539, gi... - gi\|205329344\|gb\|EDZ16108.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica sero...	0.0	[32..478]	[2..439]
gi\|16761596 - gi\|16761596\|ref\|NP_457213.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|25306158, gi\|... - gi\|25306158\|pir\|\|AG0842 multidrug resistance protein B [imported] - Salmonella enterica subsp. enter... gi\|29138709, gi\|... - gi\|29143076\|ref\|NP_806418.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|213850377 - gi\|213850377\|ref\|ZP_03381275.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ... gi\|214000013 - gi\|214000013\|ref\|ZP_03410748.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ...	0.0	[32..478]	[2..439]
gi\|60467752, gi\|... - gi\|60467752\|gb\|EAL65769.1\| hypothetical protein DDB0191430 [Dictyostelium discoideum], gi\|29500764\|g... gi\|60467752, gi\|... - gi\|66810832\|ref\|XP_639123.1\| major facilitator superfamily transporter [Dictyostelium discoideum AX4...	1.0E-99	[26..482]	[584..1035]
gi\|229896373, gi... - gi\|229896373\|ref\|ZP_04511542.1\| multidrug resistance protein B [Yersinia pestis Pestoides A], gi\|229... gi\|229899449, gi... - gi\|229899449\|ref\|ZP_04514592.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|165926632, gi... - gi\|165926632\|ref\|ZP_02222464.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|22124829, gi\|... - gi\|22124829\|ref\|NP_668252.1\| multidrug resistance protein B [Yersinia pestis KIM], gi\|21957657\|gb\|AA... gi\|166213072, gi... - gi\|166213072\|ref\|ZP_02239107.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|25306154 - pir\|\|AB0397 multidrug resistance protein B [imported] - Yersinia pestis (strain CO92) gi\|165990079, gi... - gi\|166011079\|ref\|ZP_02231977.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|51595205, gi\|... - gi\|51595205\|ref\|YP_069396.1\| MFS multidrug efflux pump, emrB subunit [Yersinia pseudotuberculosis IP... gi\|45435371, gi\|... - gi\|45440514\|ref\|NP_992053.1\| multidrug resistance protein B [Yersinia pestis biovar Microtus str. 91... gi\|218930293, gi... - gi\|218930293\|ref\|YP_002348168.1\| multidrug resistance protein B [Yersinia pestis CO92], gi\|16123425\|... gi\|149364891, gi... - gi\|149364891\|ref\|ZP_01886926.1\| multidrug resistance protein B [Yersinia pestis CA88-4125], gi\|14929... gi\|145211859, gi... - gi\|145600163\|ref\|YP_001164239.1\| multidrug resistance protein B [Yersinia pestis Pestoides F], gi\|14... gi\|167421612, gi... - gi\|167421612\|ref\|ZP_02313365.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|167051986, gi... - gi\|167399482\|ref\|ZP_02305006.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|170025556, gi... - gi\|170025556\|ref\|YP_001722061.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|167057491, gi... - gi\|167423321\|ref\|ZP_02315074.1\| multidrug resistance protein B [Yersinia pestis biovar Mediaevalis s... gi\|162354357, gi... - gi\|77633286\|ref\|ZP_00795425.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... gi\|89103813, gi\|... - gi\|89103813\|ref\|ZP_01176376.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... Q66E38\|Q66E38_YERPS - MFS multidrug efflux pump, emrB subunit - Yersinia pseudotuberculosis gi\|186894223, gi... - gi\|186894223\|ref\|YP_001871335.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|153950510, gi... - gi\|77631828\|ref\|ZP_00794414.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pse... gi\|108808750, gi... - gi\|108808750\|ref\|YP_652666.1\| multidrug resistance protein B [Yersinia pestis Antiqua], gi\|108780663... gi\|229901211, gi... - gi\|229901211\|ref\|ZP_04516333.1\| multidrug resistance protein B [Yersinia pestis Nepal516], gi\|229681... gi\|229695246, gi... - gi\|229838880\|ref\|ZP_04459039.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st...	5.0E-99	[36..478]	[5..438]
gi\|15927932, gi\|... - gi\|15927932\|ref\|NP_375465.1\| hypothetical protein SA2142 [Staphylococcus aureus subsp. aureus N315],... gi\|253314692 - gi\|253314692\|ref\|ZP_04837905.1\| hypothetical protein SauraC_00665 [Staphylococcus aureus subsp. aure... gi\|12003106, gi\|... - pir\|\|C90035 hypothetical protein SA2142 [imported] - Staphylococcus aureus (strain N315), gi\|120031... gi\|255007128 - gi\|255007128\|ref\|ZP_05145729.2\| hypothetical protein SauraM_11685 [Staphylococcus aureus subsp. aure... gi\|14248126, gi\|... - gi\|15925342\|ref\|NP_372876.1\| multidrug resistance protein [Staphylococcus aureus subsp. aureus Mu50]... gi\|269203983\|ref... - EmrB/QacA family drug resistance transporter [Staphylococcus aureus subsp. aureus ED98] gi\|90583610, gi\|... - gi\|90583610\|ref\|ZP_01239364.1\| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu... gi\|147741858, gi... - gi\|90585929\|ref\|ZP_01241634.1\| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu... gi\|156980667, gi... - gi\|156980667\|ref\|YP_001442926.1\| hypothetical protein SAHV_2336 [Staphylococcus aureus subsp. aureus...	2.0E-97	[39..513]	[135..642]
gi\|49245578, gi\|... - gi\|49487135\|ref\|YP_044356.1\| putative transport protein [Staphylococcus aureus subsp. aureus MSSA476... gi\|21205445, gi\|... - gi\|21284002\|ref\|NP_647090.1\| hypothetical protein MW2273 [Staphylococcus aureus subsp. aureus MW2], ... gi\|251813217, gi... - gi\|251813217\|ref\|ZP_04827690.1\| MFS family major facilitator transporter, multidrug:cation symporter...	2.0E-96	[39..514]	[135..640]
gi\|124528057, gi... - gi\|124528057\|ref\|ZP_01699410.1\| drug resistance transporter, EmrB/QacA subfamily [Escherichia coli B... EG11439 - multidrug efflux system protein / EmrAB-TolC multidrug resistance pump; energy-dependent efflux of o... gi\|189362003, gi... - gi\|189362003\|gb\|EDU80422.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4486], g... gi\|189367267, gi... - gi\|189367267\|gb\|EDU85683.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4501], g... gi\|168778668, gi... - gi\|189003608\|gb\|EDU72594.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4076], g... gi\|187769639, gi... - gi\|187769639\|gb\|EDU33483.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4196], g... gi\|189377146, gi... - gi\|189377146\|gb\|EDU95562.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC508], gi... gi\|189372123, gi... - gi\|189372123\|gb\|EDU90539.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC869], gi... gi\|169890103, gi... - gi\|170082268\|ref\|YP_001731588.1\| multidrug efflux system protein [Escherichia coli str. K-12 substr.... gi\|170019063, gi... - gi\|170019063\|ref\|YP_001724017.1\| EmrB/QacA family drug resistance transporter [Escherichia coli ATCC... gi\|1800071, gi\|8... - gi\|89109478\|ref\|AP_003258.1\| multidrug efflux system protein [Escherichia coli str. K-12 substr. W31... gi\|15832802, gi\|... - gi\|15832802\|ref\|NP_311575.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. Sakai], g... gi\|189357296, gi... - gi\|189357296\|gb\|EDU75715.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4401], g... gi\|188014965, gi... - gi\|188014965\|gb\|EDU53087.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4113], g... gi\|218706185, gi... - gi\|218706185\|ref\|YP_002413704.1\| multidrug efflux system protein [Escherichia coli UMN026], gi\|21843... gi\|218353014, gi... - gi\|218696282\|ref\|YP_002403949.1\| multidrug efflux system protein [Escherichia coli 55989], gi\|218353... gi\|238861814, gi... - gi\|238901828\|ref\|YP_002927624.1\| multidrug efflux system protein [Escherichia coli BW2952], gi\|23886... gi\|251785975, gi... - gi\|251785975\|ref\|YP_003000279.1\| hypothetical protein B21_02506 [Escherichia coli BL21], gi\|24237824... gi\|253978690, gi... - gi\|254289383\|ref\|YP_003055131.1\| multidrug efflux system protein [Escherichia coli BL21(DE3)], gi\|25... gi\|253974523, gi... - gi\|254162622\|ref\|YP_003045730.1\| multidrug efflux system protein [Escherichia coli B str. REL606], g... gi\|254594032, gi... - gi\|254794632\|ref\|YP_003079469.1\| multidrug efflux system protein [Escherichia coli O157:H7 str. TW14... EMRB_ECO57 - Multidrug export protein EmrB OS=Escherichia coli O157:H7 GN=emrB PE=3 SV=1 gi\|195938439 - gi\|195938439\|ref\|ZP_03083821.1\| membrane translocase [Escherichia coli O157:H7 str. EC4024] EG11439 - multidrug efflux system protein / EmrAB-TolC multidrug resistance pump; energy-dependent efflux of o... gi\|194427903, gi... - gi\|194427903\|ref\|ZP_03060449.1\| multidrug resistance protein B [Escherichia coli B171], gi\|194414136... gi\|208811845, gi... - gi\|208811845\|ref\|ZP_03253174.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4045... gi\|208726552, gi... - gi\|208806751\|ref\|ZP_03249088.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4206... gi\|209396264, gi... - gi\|209396264\|ref\|YP_002272153.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC411... gi\|208741288, gi... - gi\|208821165\|ref\|ZP_03261485.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4042... gi\|217319664, gi... - gi\|217327297\|ref\|ZP_03443380.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. TW1458... gi\|209920130, gi... - gi\|209920130\|ref\|YP_002294214.1\| multidrug resistance protein [Escherichia coli SE11], gi\|209913389\|... gi\|194439446, gi... - gi\|83585148\|ref\|ZP_00923799.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|157077975, gi... - gi\|75187410\|ref\|ZP_00700677.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|157162137, gi... - gi\|75196666\|ref\|ZP_00706736.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|75229766, gi\|... - gi\|75229766\|ref\|ZP_00716296.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|193071001, gi... - gi\|75234098\|ref\|ZP_00718509.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|188486943, gi... - gi\|75513256\|ref\|ZP_00735698.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... EMRB_ECOLI - Multidrug resistance protein B - Escherichia coli	7.0E-96	[32..478]	[2..439]
gi\|26109488, gi\|... - gi\|26249081\|ref\|NP_755121.1\| multidrug resistance protein B [Escherichia coli CFT073], gi\|26109488\|g...	9.0E-96	[32..473]	[5..437]
gi\|25306170 - gi\|25306170\|pir\|\|G85916 hypothetical protein emrB [imported] - Escherichia coli (strain O157:H7, su... gi\|12517127, gi\|... - gi\|15803205\|ref\|NP_289237.1\| multidrug resistance protein B [Escherichia coli O157:H7 EDL933], gi\|12...	2.0E-95	[32..478]	[2..439]

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Predicted Domain #1

Region A:
Residues: [1-268]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTSSSVTQK NLDTNAEALK KEDKVLSEFD IQDERPKSLL WESAFVGVLC SAQLMTQAGL  60
   61 GQSLAPLHII GNSFGTTNAG QLSWFASAYS LTVGTFILIA GRLGDIFGHK KFFVLGFFWY 120
  121 ALWSLLAGFS VYSNQIFFDC CRAFQGMGPA FLLPNAIAIL GRTYKPGRRK NMVFSLFGAS 180
  181 APGGFFLGAV FSSMLGQLAW WPWAYWIMGI ACFVLAVAGY FVIPHTPMPS RDASSFKLLE 240
  241 RIDFAGSVTG VVGLILFNFA WNQGPVVG

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [269-515]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WQTPYTYALL IVGTFFLVIF AYIESRAAFP LLPFAALSSD TAFVLSCIAA GWASFGIWIF  60
   61 YTWQFMEDSR GQTPLLSSAQ FSPVAISGFC AAVTTGFLLS HTPPSTVMLF AMTAFTVGTI 120
  121 LIATAPVHQT YWAQTFVSII VMPWGMDMSF PAATIMLSDS MPHEHQGLAA SLVNTVVNYS 180
  181 ISIGLGIAGT IESRVNDGGA KPLKGYRCSW YMGIGLSGLG IFVAATYAWS TFMKSKKRIS 240
  241 EKQHFIE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits