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View Structure Prediction Details

Protein: HEM15
Organism: Saccharomyces cerevisiae
Length: 393 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HEM15.

Description E-value Query
Range
Subject
Range
HEMH_XENLA - Ferrochelatase, mitochondrial OS=Xenopus laevis GN=fech PE=1 SV=1
0.0 [3..373] [20..392]
HEM15 - Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into...
gi|190407492 - gi|190407492|gb|EDV10759.1| ferrochelatase [Saccharomyces cerevisiae RM11-1a]
gi|151940658 - gi|151940658|gb|EDN59071.1| ferrochelatase [Saccharomyces cerevisiae YJM789]
HEMH_YEAST - Ferrochelatase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEM15 PE=1...
0.0 [1..393] [1..393]
gi|193271 - gi|193271|gb|AAA37615.1| ferrochelatase
0.0 [22..373] [29..382]
HEMH_BOVIN - Ferrochelatase, mitochondrial OS=Bos taurus GN=FECH PE=1 SV=3
0.0 [19..373] [42..398]
gi|10567634, gi|... - gi|18858665|ref|NP_571706.1| ferrochelatase [Danio rerio], gi|10567634|gb|AAG18514.1|AF250368_1 ferr...
0.0 [11..373] [26..391]
HEMH_CHICK - Ferrochelatase, mitochondrial OS=Gallus gallus GN=FECH PE=1 SV=1
0.0 [19..373] [28..384]
gi|145579542, gi... - gi|14719599|pdb|1HRK|B Chain B, Crystal Structure Of Human Ferrochelatase, gi|14719598|pdb|1HRK|A Ch...
0.0 [35..373] [1..341]
gi|15147828 - gi|15147828|emb|CAC50871.1| ferrochelatase [Nicotiana tabacum]
0.0 [12..358] [58..409]

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Predicted Domain #1
Region A:
Residues: [1-49]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSRTIRTQG SFLRRSQLTI TRSFSVTFNM QNAQKRSPTG IVLMNMGGP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [102-200]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPIRKWSEYQ ATEVCKILDK TCPETAPHKP YVAFRYAKPL TAETYKQMLK DGVKKAVAFS  60
   61 QYPHFSYSTT GSSINELWRQ IKALDSERSI SWSVIDRWP

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [341-393]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNQTFIEGMA DLVKSHLQSN QLYSNQLPLD FALGKSNDPV KDLSLVFGNH EST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1041.218487
Match: 1hrkA_
Description: Ferrochelatase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [50-101]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKVEETYDFL YQLFADNDLI PISAKYQKTI AKYIAKFRTP KIEKQYREIG GG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [201-340]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNEGLIKAFS ENITKKLQEF PQPVRDKVVL LFSAHSLPMD VVNTGDAYPA EVAATVYNIM  60
   61 QKLKFKNPYR LVWQSQVGPK PWLGAQTAEI AEFLGPKVDG LMFIPIAFTS DHIETLHEID 120
  121 LGVIGESEYK DKFKRCESLN 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1041.218487
Match: 1hrkA_
Description: Ferrochelatase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle