YRC Public Data Repository - Protein Structure Prediction

Protein:	IDH2
Organism:	Saccharomyces cerevisiae
Length:	369 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IDH2.

Description	E-value	Query Range	Subject Range
IDH2 - Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of... gi\|151945756 - gi\|151945756\|gb\|EDN63997.1\| NAD-dependent isocitrate dehydrogenase [Saccharomyces cerevisiae YJM789] IDH2_YEAST - Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204...	0.0	[1..369]	[1..369]
gi\|125569901, gi... - gi\|81686717\|dbj\|BAE48299.1\| NAD-dependent isocitrate dehydrogenase a [Oryza sativa Japonica Group], ...	0.0	[4..369]	[10..362]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[1..369]	[1..372]
IDH5_ARATH - Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial OS=Arabidopsis thaliana GN=IDH5 PE...	0.0	[1..369]	[3..374]
IDH2_KLULA - Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial OS=Kluyveromyces lactis GN=IDH2 PE=3 SV=1 IDH2_KLULA - Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial OS=Kluyveromyces lactis (strain ATCC 8585 / ...	0.0	[1..369]	[1..368]
gi\|194204815, gi... - gi\|195567723\|ref\|XP_002107408.1\| GD15579 [Drosophila simulans], gi\|194204815\|gb\|EDX18391.1\| GD15579 ... FBpp0307649 - type=protein; loc=X:complement(19413320..19413658,19413729..19413864,19413937..19414331,19414693..19...	0.0	[4..369]	[11..377]

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Predicted Domain #1

Region A:
Residues: [1-369]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRNTFFRNT SRRFLATVKQ PSIGRYTGKP NPSTGKYTVS FIEGDGIGPE ISKSVKKIFS  60
   61 AANVPIEWES CDVSPIFVNG LTTIPDPAVQ SITKNLVALK GPLATPIGKG HRSLNLTLRK 120
  121 TFGLFANVRP AKSIEGFKTT YENVDLVLIR ENTEGEYSGI EHIVCPGVVQ SIKLITRDAS 180
  181 ERVIRYAFEY ARAIGRPRVI VVHKSTIQRL ADGLFVNVAK ELSKEYPDLT LETELIDNSV 240
  241 LKVVTNPSAY TDAVSVCPNL YGDILSDLNS GLSAGSLGLT PSANIGHKIS IFEAVHGSAP 300
  301 DIAGQDKANP TALLLSSVMM LNHMGLTNHA DQIQNAVLST IASGPENRTG DLAGTATTSS 360
  361 FTEAVIKRL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	542.0
Match:	1xac__
Description:	3-isopropylmalate dehydrogenase, IPMDH
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits