YRC Public Data Repository - Protein Structure Prediction

Protein:	PTC5
Organism:	Saccharomyces cerevisiae
Length:	572 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTC5.

Description	E-value	Query Range	Subject Range
gi\|16416087 - gi\|16416087\|emb\|CAB91227.2\| related to Type 2C Protein Phosphatase [Neurospora crassa] gi\|157072042, gi... - gi\|164428175\|ref\|XP_957190.2\| hypothetical protein NCU01767 [Neurospora crassa OR74A], gi\|157072042\|...	361.0	[0..27]	[554..34]
gi\|32415453, gi\|... - gi\|32415453\|ref\|XP_328206.1\| Type 2C Protein Phosphatase related protein [MIPS] [Neurospora crassa],... gi\|85083801 - gi\|85083801\|ref\|XP_957190.1\| Type 2C Protein Phosphatase related protein [MIPS] [Neurospora crassa O...	358.0	[0..27]	[554..55]
gi\|109128838, gi... - gi\|109128838\|ref\|XP_001085932.1\| PREDICTED: pyruvate dehydrogenase phosphatase isoenzyme 2 isoform 3...	343.0	[0..60]	[549..16]
gi\|114663021, gi... - gi\|114663023\|ref\|XP_001159749.1\| PREDICTED: pyruvate dehydrogenase phosphatase isoenzyme 2 isoform 3...	343.0	[0..60]	[549..16]
PDP2 - pyruvate dehyrogenase phosphatase catalytic subunit 2 gi\|168269826 - gi\|168269826\|dbj\|BAG10040.1\| (pyruvate dehydrogenase)-phosphatase 2 [synthetic construct]	342.0	[0..60]	[549..16]
gi\|197099506 - gi\|197099506\|ref\|NP_001125771.1\| pyruvate dehydrogenase phosphatase isoenzyme 2 [Pongo abelii] gi\|55729131 - gi\|55729131\|emb\|CAH91302.1\| hypothetical protein [Pongo abelii]	341.0	[0..60]	[549..16]
gi\|45185605, gi\|... - gi\|45185605\|ref\|NP_983321.1\| ACL083Cp [Ashbya gossypii ATCC 10895], gi\|44981323\|gb\|AAS51145.1\| ACL08... gi\|44981323 - gi\|44981323\|gb\|AAS51145.1\| ACL083Cp [Ashbya gossypii ATCC 10895]	340.0	[0..12]	[572..12]
gi\|47939194, gi\|... - gi\|48675865\|ref\|NP_659559.2\| pyruvate dehydrogenase phosphatase isoenzyme 2 [Rattus norvegicus], gi\|...	332.0	[0..67]	[550..2]
gi\|73957539 - gi\|73957539\|ref\|XP_546891.2\| PREDICTED: similar to [Pyruvate dehydrogenase [Lipoamide]]-phosphatase ...	332.0	[0..46]	[549..3]

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Predicted Domain #1

Region A:
Residues: [1-106]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPLTRTVAI KKTVKVLSKC QSGREYTQKF LQRAYSTSHA NSTYYSRTKL FISSHSKALN  60
   61 IALLSGSLLL TYSYYSPKKI LSLDTINGIK DYSTNTSGNI NMPSPN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.827	d.102.1	Regulatory factor Nef
View	Download	0.635	d.129.1	TATA-box binding protein-like
View	Download	0.634	c.51.1	Anticodon-binding domain of Class II aaRS
View	Download	0.625	b.61.4	Quinohemoprotein amine dehydrogenase A chain, domain 3
View	Download	0.606	d.129.1	TATA-box binding protein-like

Predicted Domain #2

Region A:
Residues: [107-572]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKGTETQKSQ RSQNDQSVLI LNDSKIEAKL HDREESHFVN RGTGIFRYDV AQLPSNHPIE  60
   61 DDHVEQIITI PIESEDGKSI EKDLYFFGIF DGHGGPFTSE KLSKDLVRYV AYQLGQVYDQ 120
  121 NKTVFHSDPN QLIDSAISKG FLKLDNDLVI ESFRKLFQDP NNTNIANTLP AISGSCALLS 180
  181 LYNSTNSILK VAVTGDSRAL ICGLDNEGNW TVKSLSTDQT GDNLDEVRRI RKEHPGEPNV 240
  241 IRNGRILGSL QPSRAFGDYR YKIKEVDGKP LSDLPEVAKL YFRREPRDFK TPPYVTAEPV 300
  301 ITSAKIGENT KFMVMGSDGL FELLTNEEIA SLVIRWMDKN MNLAPVKAEP GKLPKVIDVS 360
  361 EDKEAQRPAF RYKDNNSSSP SGSNPEYLIE DKNVATHLIR NALSAGGRKE YVSALVSIPS 420
  421 PMSRRYRDDL TVTVAFFGDS GTPSIVSNAT SIVMNPEATT KPKPRL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	145.156545
Match:	1a6qA
Description:	CRYSTAL STRUCTURE OF THE PROTEIN SERINE/THREONINE PHOSPHATASE 2C AT 2 A RESOLUTION
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits