YRC Public Data Repository - Protein Structure Prediction

Protein:	CYT1
Organism:	Saccharomyces cerevisiae
Length:	309 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYT1.

Description	E-value	Query Range	Subject Range
CY1_YEAST - Cytochrome c1, heme protein, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ... CYT1 - Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme... gi\|207341227 - gi\|207341227\|gb\|EDZ69339.1\| YOR065Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|151945691 - gi\|151945691\|gb\|EDN63932.1\| cytochrome c1 [Saccharomyces cerevisiae YJM789] gi\|190407400 - gi\|190407400\|gb\|EDV10667.1\| cytochrome c1 [Saccharomyces cerevisiae RM11-1a]	0.0	[1..309]	[1..309]
CY1_KLULA - Cytochrome c1, heme protein, mitochondrial OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DS... CY1_KLULA - Cytochrome c1, heme protein, mitochondrial OS=Kluyveromyces lactis GN=CYT1 PE=3 SV=1	0.0	[19..306]	[5..291]
CY1_NEUCR - Cytochrome c1, heme protein, mitochondrial OS=Neurospora crassa GN=cyt-1 PE=2 SV=1 CY1_NEUCR - Cytochrome c1, heme protein, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CB...	0.0	[6..306]	[16..315]
gi\|7547401 - gi\|7547401\|gb\|AAB28813.2\| cytochrome c1 precursor [Solanum tuberosum]	0.0	[24..303]	[46..317]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[24..303]	[46..317]
CY1_SCHPO - Cytochrome c1, heme protein, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN... cyt1 - cytochrome c1	0.0	[12..305]	[16..305]

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Predicted Domain #1

Region A:
Residues: [1-309]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSNLSKRWA QRTLSKSFYS TATGAASKSG KLTQKLVTAG VAAAGITAST LLYADSLTAE  60
   61 AMTAAEHGLH APAYAWSHNG PFETFDHASI RRGYQVYREV CAACHSLDRV AWRTLVGVSH 120
  121 TNEEVRNMAE EFEYDDEPDE QGNPKKRPGK LSDYIPGPYP NEQAARAANQ GALPPDLSLI 180
  181 VKARHGGCDY IFSLLTGYPD EPPAGVALPP GSNYNPYFPG GSIAMARVLF DDMVEYEDGT 240
  241 PATTSQMAKD VTTFLNWCAE PEHDERKRLG LKTVIILSSL YLLSIWVKKF KWAGIKTRKF 300
  301 VFNPPKPRK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1578.0
Match:	1kyoD_
Description:	Cytochrome bc1 domain; Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquinol-cytochrome-c reductase activity	9.78686808279934	bayes_pls_golite062009
oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	9.78686808279934	bayes_pls_golite062009
electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity	7.65479843528878	bayes_pls_golite062009
oxidoreductase activity, acting on diphenols and related substances as donors	6.402093715172	bayes_pls_golite062009
electron carrier activity	5.89393941749361	bayes_pls_golite062009
oxidoreductase activity	4.80453374142732	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	3.95927872883558	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	3.81941996826271	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.28855051034616	bayes_pls_golite062009
cation transmembrane transporter activity	3.12657801391409	bayes_pls_golite062009
ion transmembrane transporter activity	2.97300461435278	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.64574194038684	bayes_pls_golite062009
substrate-specific transporter activity	2.51612623656281	bayes_pls_golite062009
electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity	1.96628396955281	bayes_pls_golite062009
binding	0.972223231507636	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	0.95569494562262	bayes_pls_golite062009
peroxidase activity	0.95569494562262	bayes_pls_golite062009
antioxidant activity	0.72039892017668	bayes_pls_golite062009
protein binding	0.180623301978971	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: