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View Structure Prediction Details

Protein: MED7
Organism: Saccharomyces cerevisiae
Length: 222 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MED7.

Description E-value Query
Range
Subject
Range
MED7 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form ...
gi|151945501 - gi|151945501|gb|EDN63742.1| mediator complex subunit [Saccharomyces cerevisiae YJM789]
MED7_YEAST - Mediator of RNA polymerase II transcription subunit 7 OS=Saccharomyces cerevisiae (strain ATCC 20450...
1.0E-68 [1..213] [1..213]
gi|15242771 - gi|15242771|ref|NP_195970.1| unknown protein [Arabidopsis thaliana]
1.0E-49 [10..203] [3..158]
gi|114603124 - gi|114603124|ref|XP_527095.2| PREDICTED: cofactor required for Sp1 transcriptional activation, subun...
gi|61361428, gi|... - gi|61361434|gb|AAX42047.1| cofactor required for Sp1 transcriptional activation subunit 9 [synthetic...
MED7 - mediator complex subunit 7
1.0E-49 [5..210] [3..175]
MED7_MOUSE - Mediator of RNA polymerase II transcription subunit 7 OS=Mus musculus GN=Med7 PE=1 SV=2
4.0E-49 [5..210] [3..175]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-43 [10..203] [3..158]

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Predicted Domain #1
Region A:
Residues: [1-222]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNDPGNEVS SLYPPPPPYV KFFTQSNLEK LPKYKEKKAA SAKQTAPNNS NGGSEEEITC  60
   61 ALDYLIPPPM PKNQQYRAFG SIWQVKDQLP DLESMGLTQL YKKSTENEST NYQYKIQELR 120
  121 KLLKSLLLNY LELIGVLSIN PDMYERKVEN IRTILVNIHH LLNEYRPHQS RESLIMLLEE 180
  181 QLEYKRGEIR EIEQVCKQVH DKLTSIQDTL RTGSQSPPSS SQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [107-222]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NESTNYQYKI QELRKLLKSL LLNYLELIGV LSINPDMYER KVENIRTILV NIHHLLNEYR  60
   61 PHQSRESLIM LLEEQLEYKR GEIREIEQVC KQVHDKLTSI QDTLRTGSQS PPSSSQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.522879
Match: 1ykeA
Description: Structure of the mediator MED7/MED21 subcomplex
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle