YRC Public Data Repository - Protein Structure Prediction

Protein:	MED7
Organism:	Saccharomyces cerevisiae
Length:	222 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MED7.

Description	E-value	Query Range	Subject Range
MED7 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form ... gi\|151945501 - gi\|151945501\|gb\|EDN63742.1\| mediator complex subunit [Saccharomyces cerevisiae YJM789] MED7_YEAST - Mediator of RNA polymerase II transcription subunit 7 OS=Saccharomyces cerevisiae (strain ATCC 20450...	1.0E-68	[1..213]	[1..213]
gi\|15242771 - gi\|15242771\|ref\|NP_195970.1\| unknown protein [Arabidopsis thaliana]	1.0E-49	[10..203]	[3..158]
gi\|114603124 - gi\|114603124\|ref\|XP_527095.2\| PREDICTED: cofactor required for Sp1 transcriptional activation, subun... gi\|61361428, gi\|... - gi\|61361434\|gb\|AAX42047.1\| cofactor required for Sp1 transcriptional activation subunit 9 [synthetic... MED7 - mediator complex subunit 7	1.0E-49	[5..210]	[3..175]
MED7_MOUSE - Mediator of RNA polymerase II transcription subunit 7 OS=Mus musculus GN=Med7 PE=1 SV=2	4.0E-49	[5..210]	[3..175]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-43	[10..203]	[3..158]

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Predicted Domain #1

Region A:
Residues: [1-222]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNDPGNEVS SLYPPPPPYV KFFTQSNLEK LPKYKEKKAA SAKQTAPNNS NGGSEEEITC  60
   61 ALDYLIPPPM PKNQQYRAFG SIWQVKDQLP DLESMGLTQL YKKSTENEST NYQYKIQELR 120
  121 KLLKSLLLNY LELIGVLSIN PDMYERKVEN IRTILVNIHH LLNEYRPHQS RESLIMLLEE 180
  181 QLEYKRGEIR EIEQVCKQVH DKLTSIQDTL RTGSQSPPSS SQ

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [107-222]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NESTNYQYKI QELRKLLKSL LLNYLELIGV LSINPDMYER KVENIRTILV NIHHLLNEYR  60
   61 PHQSRESLIM LLEEQLEYKR GEIREIEQVC KQVHDKLTSI QDTLRTGSQS PPSSSQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.522879
Match:	1ykeA
Description:	Structure of the mediator MED7/MED21 subcomplex
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits