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View Structure Prediction Details

Protein: MPD2
Organism: Saccharomyces cerevisiae
Length: 277 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MPD2.

Description E-value Query
Range		 Subject
Range
MPD2 - Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression ...
MPD2_YEAST - Protein disulfide isomerase MPD2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MPD2 PE...
 9.0E-45 [1..277] [1..277]
gi|14626709, gi|... - gi|68394965|ref|XP_702014.1| PREDICTED: hypothetical protein XP_696922 [Danio rerio], gi|56207705|em...
 3.0E-43 [7..246] [4..248]
gi|12838858 - gi|12838858|dbj|BAB24354.1| unnamed protein product [Mus musculus]
 7.0E-41 [3..241] [6..248]
PDIA6_MESAU - Protein disulfide-isomerase A6 OS=Mesocricetus auratus GN=PDIA6 PE=1 SV=1
 1.0E-40 [3..241] [1..243]
gi|123980566, gi... - gi|123995387|gb|ABM85295.1| protein disulfide isomerase family A, member 6 [synthetic construct], gi...
PDIA6 - protein disulfide isomerase family A, member 6
HGNC:30168|MIM:6... - disulfide isomerase family A, member 6
 5.0E-40 [1..241] [1..243]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 2.0E-39 [2..255] [122..356]
PDIA6_RAT - Protein disulfide-isomerase A6 OS=Rattus norvegicus GN=Pdia6 PE=1 SV=2
 2.0E-39 [14..241] [4..234]
PDI22_ORYSJ - Protein disulfide isomerase-like 2-2 OS=Oryza sativa subsp. japonica GN=PDIL2-2 PE=2 SV=1
gi|125525761 - gi|125525761|gb|EAY73875.1| hypothetical protein OsI_01755 [Oryza sativa Indica Group]
 7.0E-39 [2..254] [133..366]
gi|145254554 - gi|145254554|ref|XP_001398661.1| disulfide isomerase tigA-Aspergillus niger
TIGA_ASPNG - Protein disulfide-isomerase tigA OS=Aspergillus niger GN=tigA PE=2 SV=1
 1.0E-38 [7..243] [4..224]

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Predicted Domain #1
Region A:
Residues: [1-144] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLHGFLFSV LSTCVVILPA LAYSEAVTMV KSIEQYFDIC NRNDSYTMIK YYTSWCQHCK  60
   61 TLAPVYEELG ELYAKKANKD DTPINFLEVN CEFFGPTLCT DLPGFPIIEL VKPRTKPLVL 120
  121 PKLDWSSMKF HERLWQRIKT WFNN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.522879
Match: 1quwA_
Description: Thioredoxin
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [145-277] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKYQLDTSRV VRFEGSRNLK SLSNFIDTVR SKDTEERFIE HIFDDSRNCN EELRSQQLLC  60
   61 KAGKEYYSDT LSKLYGDVNG LEKERRRLEA LIKQNGDDLS KEVKEKLKII RLQLSLLSHI 120
  121 EDQLEDTSSH DEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.69897
Match: 1bjx__
Description: Protein disulfide isomerase, PDI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein disulfide isomerase activity 4.54149370439152 bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds 4.54149370439152 bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups 4.32416700334664 bayes_pls_golite062009
disulfide oxidoreductase activity 1.07184913651636 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 0.858243161645005 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
protein disulfide oxidoreductase activity 0.44918717550973 bayes_pls_golite062009
binding 0.235855919597681 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle