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View Structure Prediction Details

Protein: GPD2
Organism: Saccharomyces cerevisiae
Length: 440 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GPD2.

Description E-value Query
Range
Subject
Range
gi|151945575 - gi|151945575|gb|EDN63816.1| glycerol-3-phosphate dehydrogenase (NAD+) [Saccharomyces cerevisiae YJM7...
GPD2_YEAST - Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial OS=Saccharomyces cerevisiae (strain ATC...
gi|190407286 - gi|190407286|gb|EDV10553.1| glycerol-3-phosphate dehydrogenase [Saccharomyces cerevisiae RM11-1a]
GPD2 - NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an o...
0.0 [1..440] [1..440]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
8.0E-97 [49..414] [1..366]
gi|577307 - gi|577307|dbj|BAA07648.1| KIAA0089 [Homo sapiens]
1.0E-95 [37..434] [31..406]
GPD1_ZYGRO - Glycerol-3-phosphate dehydrogenase [NAD(+)] 1 OS=Zygosaccharomyces rouxii GN=GPD1 PE=3 SV=1
5.0E-95 [63..439] [14..389]
GPDA_MOUSE - Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Mus musculus GN=Gpd1 PE=1 SV=3
5.0E-93 [84..434] [4..344]

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Predicted Domain #1
Region A:
Residues: [1-71]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLAVRRLTRY TFLKRTHPVL YTRRAYKILP SRSTFLRRSL LQTQLHSKMT AHTNIKQHKH  60
   61 CHEDHPIRRS D

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.368 a.16.1 S15/NS1 RNA-binding domain
View Download 0.460 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.401 a.46.1 Methionine synthase domain
View Download 0.393 a.7.6 Ribosomal protein S20
View Download 0.820 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.717 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.679 a.7.7 BAG domain
View Download 0.641 a.7.1 Spectrin repeat
View Download 0.636 i.1.1 Ribosome and ribosomal fragments
View Download 0.618 a.112.1 Description not found.
View Download 0.364 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.359 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.356 a.65.1 Annexin
View Download 0.342 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.318 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.294 a.4.5 "Winged helix" DNA-binding domain
View Download 0.289 a.7.7 BAG domain
View Download 0.289 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.285 a.16.1 S15/NS1 RNA-binding domain
View Download 0.283 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.282 a.4.5 "Winged helix" DNA-binding domain
View Download 0.272 a.118.1 ARM repeat
View Download 0.261 a.126.1 Serum albumin-like
View Download 0.239 a.24.3 Cytochromes
View Download 0.218 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.216 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.213 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.203 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.203 i.1.1 Ribosome and ribosomal fragments
View Download 0.202 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.202 a.4.5 "Winged helix" DNA-binding domain

Predicted Domain #2
Region A:
Residues: [72-289]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAVSIVHLKR APFKVTVIGS GNWGTTIAKV IAENTELHSH IFEPEVRMWV FDEKIGDENL  60
   61 TDIINTRHQN VKYLPNIDLP HNLVADPDLL HSIKGADILV FNIPHQFLPN IVKQLQGHVA 120
  121 PHVRAISCLK GFELGSKGVQ LLSSYVTDEL GIQCGALSGA NLAPEVAKEH WSETTVAYQL 180
  181 PKDYQGDGKD VDHKILKLLF HRPYFHVNVI DDVAGISI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [334-347]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PESKVETYYQ ESAG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 216.440336
Match: 1evyA_
Description: Glycerol-3-phosphate dehydrogenase; Glycerol-3- phosphate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [290-333]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGALKNVVAL ACGFVEGMGW GNNASAAIQR LGLGEIIKFG RMFF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [348-440]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VADLITTCSG GRNVKVATYM AKTGKSALEA EKELLNGQSA QGIITCREVH EWLQTCELTQ  60
   61 EFPLFEAVYQ IVYNNVRMED LPEMIEELDI DDE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 216.440336
Match: 1evyA_
Description: Glycerol-3-phosphate dehydrogenase; Glycerol-3- phosphate dehydrogenase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle