YRC Public Data Repository - Protein Structure Prediction

Protein:	YOL019W
Organism:	Saccharomyces cerevisiae
Length:	551 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YOL019W.

Description	E-value	Query Range	Subject Range
YOL019W - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell pe... YOL19_YEAST - Uncharacterized membrane protein YOL019W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...	0.0	[1..551]	[1..551]
gi\|85099060 - gi\|85099060\|ref\|XP_960709.1\| hypothetical protein NCU01357 [Neurospora crassa OR74A] gi\|28922227, gi\|... - gi\|32412740\|ref\|XP_326850.1\| hypothetical protein ( (AL353822) related to palI protein [Neurospora c...	8.0E-53	[11..194]	[10..212]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	8.0E-53	[11..194]	[51..253]
MUG33_SCHPO - Meiotically up-regulated gene 33 protein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=m... mug33 - conserved fungal protein	1.0E-49	[12..211]	[9..199]
PALI_EMENI - pH-response regulator protein palI/RIM9 OS=Emericella nidulans GN=palI PE=1 SV=2 PALI_EMENI - pH-response regulator protein palI/RIM9 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 11...	3.0E-42	[13..215]	[10..205]
gi\|16904252 - gi\|16904252\|gb\|AAL30833.1\|AF440398_1 pal1-like protein [Mycosphaerella graminicola]	2.0E-25	[13..100]	[9..92]

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Predicted Domain #1

Region A:
Residues: [1-230]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKNSSVVFF LVGLSQFVTM AFLIIGSITA PIFKQIGYSK YDEITYGTFG YCKEGSCSKA  60
   61 SYNYHPDELS DSDSNWKLNS NARSILGKII FITPIAAGLN FLGFLCTIMS VLLINVLSSD 120
  121 RVGSASAIMF FVNLTFSTLG FLSASLICIV VFLLFYPHVT WCSWVLIPGA ALSLLVIPLI 180
  181 FSAYSRSSGS RDDDETEELE EKGMLLNDPY LSSKSGRFDI DADSEANLRG

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	1.42809297010901	bayes_pls_golite062009
protein binding	0.749555781220334	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [231-551]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSRTNLLGDN FKNGTNITVV PDIISHNQDP KLSNITTSTT SDISTFDKEA KDMENSNGSG  60
   61 LNEEEDDGMA YDKRRSTSTY SVIESESGLK NGSVSNNYVR NNGSNTSNNI NYKVPLGKTE 120
  121 ISSSASLASS DYSQREVIPH RNPSRLLNDI METSFNEPND SHINSMSSYN DKDSTLTSIS 180
  181 QRGVNPEVYN QMPRETAAGP ANIRPYAGQP HPAPLVYPQQ RLQPQQQQPQ QQYHQYNLYQ 240
  241 RTTPAGPDPS NVILQSNPYF NVAPNQVPQH RNPVPGVGFA PNPLPNQSPI TQGYKPAYKR 300
  301 RMQNKNLPRA TTSLNNPYGF R

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.69
Match:	1m2vB
Description:	Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [442-551]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAPLVYPQQR LQPQQQQPQQ QYHQYNLYQR TTPAGPDPSN VILQSNPYFN VAPNQVPQHR  60
   61 NPVPGVGFAP NPLPNQSPIT QGYKPAYKRR MQNKNLPRAT TSLNNPYGFR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: