YRC Public Data Repository - Protein Structure Prediction

Protein:	LYS9
Organism:	Saccharomyces cerevisiae
Length:	446 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LYS9.

Description	E-value	Query Range	Subject Range
LYS9 - Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine fro... gi\|190408952 - gi\|190408952\|gb\|EDV12217.1\| saccharopine dehydrogenase [Saccharomyces cerevisiae RM11-1a] gi\|207341544 - gi\|207341544\|gb\|EDZ69570.1\| YNR050Cp-like protein [Saccharomyces cerevisiae AWRI1631] LYS9_YEAST - Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] OS=Saccharomyces cerevisiae (strain ATCC 2... gi\|151944578 - gi\|151944578\|gb\|EDN62856.1\| lysine requiring protein [Saccharomyces cerevisiae YJM789]	0.0	[1..446]	[1..446]
gi\|164426869, gi... - gi\|164426869\|ref\|XP_961095.2\| saccharopine dehydrogenase [Neurospora crassa OR74A], gi\|157071510\|gb\|... gi\|12718328 - gi\|12718328\|emb\|CAC28679.1\| probable saccharopine reductase [Neurospora crassa]	0.0	[4..446]	[6..448]
gi\|16555763 - gi\|16555763\|emb\|CAC87475.1\| saccharopine reductase [Penicillium chrysogenum]	0.0	[2..445]	[7..449]
LYS9_MAGO7 - Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] OS=Magnaporthe oryzae (strain 70-15 / ATCC... LYS9_MAGGR - Saccharopine dehydrogenase [NADP+, L-glutamate-forming] OS=Magnaporthe grisea GN=LYS3 PE=1 SV=2	0.0	[2..446]	[3..450]
LYS9_SCHPO - Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] OS=Schizosaccharomyces pombe (strain 972 /... SPBC3B8.03 - saccharopine dehydrogenase	0.0	[5..445]	[4..447]
gi\|4938304 - gi\|4938304\|emb\|CAA07619.2\| lysine-ketoglutarate reductase /saccharopine dehydrogenase [Homo sapiens]	0.0	[3..445]	[481..924]
gi\|15077763 - gi\|15077763\|gb\|AAK83327.1\| chimeric spermidine synthase/saccharopine dehydrogenase [Filobasidiella n...	0.0	[2..445]	[304..748]
AASS_MOUSE - Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Mus musculus GN=Aass PE=1 SV=1	0.0	[2..445]	[480..924]

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Predicted Domain #1

Region A:
Residues: [1-123]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKNVLLLGS GFVAQPVIDT LAANDDINVT VACRTLANAQ ALAKPSGSKA ISLDVTDDSA  60
   61 LDKVLADNDV VISLIPYTFH PNVVKSAIRT KTDVVTSSYI SPALRELEPE IVKAGITVMN 120
  121 EIG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [395-420]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGYPVAIATK FVLDGTIKGP GLLAPY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1794.0
Match:	1e5lA_
Description:	Saccharopine reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [124-253]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDPGIDHLYA VKTIDEVHRA GGKLKSFLSY CGGLPAPEDS DNPLGYKFSW SSRGVLLALR  60
   61 NSAKYWKDGK IETVSSEDLM ATAKPYFIYP GYAFVCYPNR DSTLFKDLYH IPEAETVIRG 120
  121 TLRYQGFPEF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [345-394]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELMQYEDNER DMVVLQHKFG IEWADGTTET RTSTLVDYGK VGGYSSMAAT

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [421-446]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPEINDPIMK ELKDKYGIYL KEKTVA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1794.0
Match:	1e5lA_
Description:	Saccharopine reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [254-344]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKALVDMGML KDDANEIFSK PIAWNEALKQ YLGAKSTSKE DLIASIDSKA TWKDDEDRER  60
   61 ILSGFAWLGL FSDAKITPRG NALDTLCARL E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1794.0
Match:	1e5lA_
Description:	Saccharopine reductase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits