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View Structure Prediction Details

Protein: MON2
Organism: Saccharomyces cerevisiae
Length: 1636 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MON2.

Description E-value Query
Range
Subject
Range
MON2 - Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p a...
gi|207341960 - gi|207341960|gb|EDZ69873.1| YNL297Cp-like protein [Saccharomyces cerevisiae AWRI1631]
MON2_YEAST - Protein MON2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MON2 PE=1 SV=1
0.0 [1..1636] [1..1636]
gi|44983299 - gi|44983299|gb|AAS52481.1| AEL204Cp [Ashbya gossypii ATCC 10895]
gi|44983299, gi|... - gi|45190403|ref|NP_984657.1| AEL204Cp [Ashbya gossypii ATCC 10895], gi|44983299|gb|AAS52481.1| AEL20...
0.0 [1..1635] [1..1589]
SPAC23D3.13c - guanyl-nucleotide exchange factor
MON2_SCHPO - Protein MON2 homolog OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mon2 PE=1 SV=1
0.0 [10..1577] [2..1568]
gi|15241106 - gi|15241106|ref|NP_198149.1| binding [Arabidopsis thaliana]
0.0 [11..1612] [3..1598]
mon-2 - status:Partially_confirmed UniProt:Q19338 protein_id:CAA92830.1
0.0 [1..1627] [1..1626]
BIG1_BOVIN - Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Bos taurus GN=ARFGEF1 PE=1 SV=1
0.0 [360..1376] [837..1713]
gi|225000702 - gi|225000702|gb|AAI72243.1| ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A...
ARFGEF1 - ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
0.0 [360..1376] [837..1713]

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Predicted Domain #1
Region A:
Residues: [1-220]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMNTGGFDS MQRQLEAELR SLSSESKRRN STIRHASDKS IEILKRVHSF EELERHPDFA  60
   61 LPFVLACQSR NAKMTTLAMQ CLQGLSTVPS IPRSRLSEIL DAFIEATHLA MEIQLKVLQV 120
  121 VPIFFKTYGK FIYGPLCKKL LLCCSNLLHV PNKAPVVVGT ASATLQQLID EIFDRLSIES 180
  181 VVDDKQYEVL ISNSESIKVN VYRYDANKLF DNICSLNEIS 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [221-326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNGAVSDEEM LLDIGDIPID YGLEILESIL KNSQKNLLEC QDLQYLLRVK AIPLLLRCIS  60
   61 SSRHFSTAVR SCRCLKLLIR KEYLSILELE LEVILSLLIH GISVES

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.851 0.039 protein targeting to vacuole a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.855 0.039 protein targeting to vacuole a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.812 0.039 protein targeting to vacuole a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.784 0.039 protein targeting to vacuole a.60.9 lambda integrase-like, N-terminal domain
View Download 0.855 0.039 protein targeting to vacuole a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.851 0.039 protein targeting to vacuole a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.812 0.039 protein targeting to vacuole a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.784 0.039 protein targeting to vacuole a.60.9 lambda integrase-like, N-terminal domain
View Download 0.784 0.039 protein targeting to vacuole a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.784 0.039 protein targeting to vacuole a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.774 0.039 protein targeting to vacuole a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.694 0.039 protein targeting to vacuole a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.633 0.039 protein targeting to vacuole a.41.1 Domain of poly(ADP-ribose) polymerase
View Download 0.575 0.039 protein targeting to vacuole a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.556 0.039 protein targeting to vacuole a.47.2 t-snare proteins
View Download 0.555 0.039 protein targeting to vacuole a.118.11 Cytochrome c oxidase subunit E
View Download 0.548 0.039 protein targeting to vacuole a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.542 0.039 protein targeting to vacuole a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.525 0.039 protein targeting to vacuole a.5.4 Elongation factor TFIIS domain 2
View Download 0.523 0.039 protein targeting to vacuole a.74.1 Cyclin-like
View Download 0.515 0.039 protein targeting to vacuole d.110.4 SNARE-like
View Download 0.498 0.039 protein targeting to vacuole d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.496 0.039 protein targeting to vacuole a.85.1 Hemocyanin, N-terminal domain
View Download 0.475 0.039 protein targeting to vacuole a.74.1 Cyclin-like
View Download 0.462 0.039 protein targeting to vacuole a.2.3 Chaperone J-domain
View Download 0.442 0.039 protein targeting to vacuole e.37.1 Bifunctional dehydrogenase/ferrochelatase Met8p, dimerisation and C-terminal domains
View Download 0.435 0.039 protein targeting to vacuole a.24.3 Cytochromes
View Download 0.434 0.039 protein targeting to vacuole a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.424 0.039 protein targeting to vacuole d.8.1 Urease, gamma-subunit
View Download 0.418 0.039 protein targeting to vacuole a.24.4 Hemerythrin
View Download 0.411 0.039 protein targeting to vacuole a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.379 0.039 protein targeting to vacuole a.118.12 Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain
View Download 0.370 0.039 protein targeting to vacuole a.4.5 "Winged helix" DNA-binding domain
View Download 0.367 0.039 protein targeting to vacuole a.4.5 "Winged helix" DNA-binding domain
View Download 0.367 0.039 protein targeting to vacuole a.165.1 Myosin phosphatase inhibitor 17kDa protein, CPI-17
View Download 0.365 0.039 protein targeting to vacuole f.14.1 Voltage-gated potassium channels
View Download 0.362 0.039 protein targeting to vacuole a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.357 0.039 protein targeting to vacuole a.26.1 4-helical cytokines
View Download 0.354 0.039 protein targeting to vacuole d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.352 0.039 protein targeting to vacuole a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.349 0.039 protein targeting to vacuole a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.346 0.039 protein targeting to vacuole a.74.1 Cyclin-like
View Download 0.340 0.039 protein targeting to vacuole a.61.1 Retroviral matrix proteins
View Download 0.333 0.039 protein targeting to vacuole a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.330 0.039 protein targeting to vacuole a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.319 0.039 protein targeting to vacuole a.39.1 EF-hand
View Download 0.318 0.039 protein targeting to vacuole a.118.1 ARM repeat
View Download 0.317 0.039 protein targeting to vacuole a.7.8 GAT domain
View Download 0.311 0.039 protein targeting to vacuole a.23.3 Methane monooxygenase hydrolase, gamma subunit
View Download 0.307 0.039 protein targeting to vacuole d.70.1 Yest killer toxins
View Download 0.307 0.039 protein targeting to vacuole d.13.1 HIT-like
View Download 0.306 0.039 protein targeting to vacuole a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.304 0.039 protein targeting to vacuole d.95.2 Homing endonucleases
View Download 0.292 0.039 protein targeting to vacuole a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.292 0.039 protein targeting to vacuole e.20.1 Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment
View Download 0.291 0.039 protein targeting to vacuole a.11.2 Second domain of FERM
View Download 0.290 0.039 protein targeting to vacuole d.134.1 Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
View Download 0.289 0.039 protein targeting to vacuole a.7.1 Spectrin repeat
View Download 0.286 0.039 protein targeting to vacuole a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.285 0.039 protein targeting to vacuole a.159.2 FF domain
View Download 0.283 0.039 protein targeting to vacuole a.63.1 Apolipophorin-III
View Download 0.282 0.039 protein targeting to vacuole a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.281 0.039 protein targeting to vacuole a.23.2 Diol dehydratase, gamma subunit
View Download 0.274 0.039 protein targeting to vacuole a.24.17 Group V grass pollen allergen
View Download 0.266 0.039 protein targeting to vacuole a.90.1 Transcription factor STAT-4 N-domain
View Download 0.260 0.039 protein targeting to vacuole a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.260 0.039 protein targeting to vacuole a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.256 0.039 protein targeting to vacuole d.224.1 SufE-like
View Download 0.255 0.039 protein targeting to vacuole a.24.15 FAD-dependent thiol oxidase
View Download 0.254 0.039 protein targeting to vacuole a.118.1 ARM repeat
View Download 0.254 0.039 protein targeting to vacuole a.24.1 Apolipoprotein
View Download 0.252 0.039 protein targeting to vacuole a.61.1 Retroviral matrix proteins
View Download 0.250 0.039 protein targeting to vacuole a.17.1 p8-MTCP1
View Download 0.244 0.039 protein targeting to vacuole a.24.11 Bacterial GAP domain
View Download 0.241 0.039 protein targeting to vacuole a.7.6 Ribosomal protein S20
View Download 0.237 0.039 protein targeting to vacuole a.118.9 ENTH/VHS domain
View Download 0.235 0.039 protein targeting to vacuole f.32.1 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.231 0.039 protein targeting to vacuole f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.227 0.039 protein targeting to vacuole a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.227 0.039 protein targeting to vacuole a.74.1 Cyclin-like
View Download 0.226 0.039 protein targeting to vacuole a.158.1 F-box domain
View Download 0.225 0.039 protein targeting to vacuole a.29.2 Bromodomain
View Download 0.223 0.039 protein targeting to vacuole f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.221 0.039 protein targeting to vacuole a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.217 0.039 protein targeting to vacuole a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.217 0.039 protein targeting to vacuole a.26.1 4-helical cytokines
View Download 0.213 0.039 protein targeting to vacuole a.39.1 EF-hand
View Download 0.212 0.039 protein targeting to vacuole a.24.9 alpha-catenin/vinculin
View Download 0.212 0.039 protein targeting to vacuole c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.211 0.039 protein targeting to vacuole a.39.1 EF-hand
View Download 0.208 0.039 protein targeting to vacuole b.34.9 Tudor/PWWP/MBT
View Download 0.206 0.039 protein targeting to vacuole a.4.5 "Winged helix" DNA-binding domain
View Download 0.206 0.039 protein targeting to vacuole a.162.1 Pre-protein croslinking domain of SecA
View Download 0.206 0.039 protein targeting to vacuole a.24.3 Cytochromes
View Download 0.203 0.039 protein targeting to vacuole c.47.2 RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View Download 0.203 0.039 protein targeting to vacuole a.75.1 Ribosomal protein S7
View Download 0.203 0.039 protein targeting to vacuole a.28.2 Colicin E immunity proteins
View Download 0.202 0.039 protein targeting to vacuole d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.202 0.039 protein targeting to vacuole a.144.1 PABC (PABP) domain
View Download 0.202 0.039 protein targeting to vacuole a.39.1 EF-hand
View Download 0.201 0.039 protein targeting to vacuole d.68.1 Translation initiation factor IF3, C-terminal domain

Predicted Domain #3
Region A:
Residues: [327-1393]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLSGWQRVLS LELFKDLSQD PEIVNTLYMD YDNYPDKKHV FKYLLKECIV LLNSPEYITF  60
   61 LAPSKVVEKM DSPLITTENS TVKTKFMHLL DKSNAPSINI TYIISLILTI CNHLCEGLNK 120
  121 SALESSPLEK KIEDKEREEG TGNDSTVVKV YSGLFSGLFE LNKLFLYSTS LETSIFHLVV 180
  181 RAFQKLAHSA GVLSLKDKLR ACMKLFSILI TNNVTSSNQY SFNDTSKSAK NQHTRNISTS 240
  241 SVTTSPVEST KNPSRSIADS AQNKEMKRRL HPRNISSRQV SLLRALISLS ISLGPIFDSE 300
  301 SWRYTFLTWQ WITYYIYGPS ADFKESFYSE DIPPPPILTK SDVTSIESSL TKFFESTSSY 360
  361 SCSTFHLVLT RLILDSKNTL TLEQTNLNLN NDIGYHPLDA KDEIIPCIYN KAFFVNKIGE 420
  421 LATYNCKKFL FGKNGKELWS LISTYMIKLI SNREMDNDSL RLYTVRVFTD IIKKATNEVG 480
  481 NSDEQDNKVK QFGTLENLVI DSLMATINSI KQLDIGKQEI YNGTINVESD ILFQLLLTLK 540
  541 EILNEFGELL MNSWTNIFNI INSPFEWTVE DTDFSVNEDI DDSSLFEGIV QKHKNMIQVS 600
  601 YDVFKLISDD FLQSLPMSVI KFVIDTLVNF VSQKRNLNIS FSSISQFWLV GDYLRVRFNP 660
  661 ETLNLSDEKR RSLSEKINNQ KLIEIITSSS SHDWELYNGL WIYLLKNLIN CTNDDRVEVK 720
  721 NGAVQTFFRI IDSHSVCFPP WDLIFLEVIE PLLTKEWSTE ELENETDFIN VTLQGLIKLY 780
  781 PEHFKDFKNN TTCAKEWSML LDFLKRLLSS TSNNTKNAVI LNYQTLLKEI ITIEDVPSDI 840
  841 LKKCCEIFTD YNITYSDLST NASSKTEYDC IYELITGFPP LYQLISKYDA MTDEFVEKVL 900
  901 LLFNSAIKYP LLPEFVQDKT KPSSMQKAIL SGLDIFMTND SKDTEILILL QLSTISILAF 960
  961 DTREKITKKL GPKLPKASLN RLPTFEAISY MSCSNLRNRI AKIDQFGIST LKAKHILRIL1020
 1021 KNLAEIIKRK SLITGSESDE IPIWVLASNC FCDLSNKIFK SLQEDAE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [1394-1636]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPLKDNFCDL FINVIVVTLQ RINPELDNLT EIDDLNEYSK YREILLENRI IDLFNERQLD  60
   61 TFIYAVWDCS FLYEFDELEN ALMQDCGTFS ELSQKLSSFD FSCIFGSTTN PRFQTKYKCS 120
  121 LECLQDLVNF MLNTNEKLRK LTAPYLSARI ALALRRYISD EYLIGRAPIP KLRKTELATL 180
  181 LNGLCVILRG VLDQNSTLGN KQIGVENLQT LSPLILRTIP VSHKMDGLQD KVLELSLGFT 240
  241 KLD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [663-782]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILTKSDVTSI ESSLTKFFES TSSYSCSTFH LVLTRLILDS KNTLTLEQTN LNLNNDIGYH  60
   61 PLDAKDEIIP CIYNKAFFVN KIGELATYNC KKFLFGKNGK ELWSLISTYM IKLISNREMD 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.13
Match: 2ie3A
Description: No description for 2ie3A was found.

Predicted Domain #6
Region A:
Residues: [783-1559]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDSLRLYTVR VFTDIIKKAT NEVGNSDEQD NKVKQFGTLE NLVIDSLMAT INSIKQLDIG  60
   61 KQEIYNGTIN VESDILFQLL LTLKEILNEF GELLMNSWTN IFNIINSPFE WTVEDTDFSV 120
  121 NEDIDDSSLF EGIVQKHKNM IQVSYDVFKL ISDDFLQSLP MSVIKFVIDT LVNFVSQKRN 180
  181 LNISFSSISQ FWLVGDYLRV RFNPETLNLS DEKRRSLSEK INNQKLIEII TSSSSHDWEL 240
  241 YNGLWIYLLK NLINCTNDDR VEVKNGAVQT FFRIIDSHSV CFPPWDLIFL EVIEPLLTKE 300
  301 WSTEELENET DFINVTLQGL IKLYPEHFKD FKNNTTCAKE WSMLLDFLKR LLSSTSNNTK 360
  361 NAVILNYQTL LKEIITIEDV PSDILKKCCE IFTDYNITYS DLSTNASSKT EYDCIYELIT 420
  421 GFPPLYQLIS KYDAMTDEFV EKVLLLFNSA IKYPLLPEFV QDKTKPSSMQ KAILSGLDIF 480
  481 MTNDSKDTEI LILLQLSTIS ILAFDTREKI TKKLGPKLPK ASLNRLPTFE AISYMSCSNL 540
  541 RNRIAKIDQF GISTLKAKHI LRILKNLAEI IKRKSLITGS ESDEIPIWVL ASNCFCDLSN 600
  601 KIFKSLQEDA ENPLKDNFCD LFINVIVVTL QRINPELDNL TEIDDLNEYS KYREILLENR 660
  661 IIDLFNERQL DTFIYAVWDC SFLYEFDELE NALMQDCGTF SELSQKLSSF DFSCIFGSTT 720
  721 NPRFQTKYKC SLECLQDLVN FMLNTNEKLR KLTAPYLSAR IALALRRYIS DEYLIGR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.974
Match: 1w63A
Description: AP1 clathrin adaptor core
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1560-1636]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APIPKLRKTE LATLLNGLCV ILRGVLDQNS TLGNKQIGVE NLQTLSPLIL RTIPVSHKMD  60
   61 GLQDKVLELS LGFTKLD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle