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View Structure Prediction Details

Protein: MET2
Organism: Saccharomyces cerevisiae
Length: 486 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MET2.

Description E-value Query
Range		 Subject
Range
MET2_YEAST - Homoserine O-acetyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET2 PE=1...
MET2 - L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine whic...
 0.0 [1..486] [1..486]
MET2_SACPS - Homoserine O-acetyltransferase OS=Saccharomyces pastorianus GN=MET2 PE=3 SV=1
gi|295620|gb|AAB... - homoserine-O-acetyltransferase
 0.0 [1..486] [1..486]
MET2_EMENI - Homoserine O-acetyltransferase OS=Emericella nidulans GN=metE PE=3 SV=1
MET2_EMENI - Homoserine O-acetyltransferase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NR...
 0.0 [1..486] [1..489]
gi|85108758 - gi|85108758|ref|XP_962641.1| HOMOSERINE O-ACETYLTRANSFERASE (HOMOSERINE O-TRANS-ACETYLASE) [Neurospo...
gi|15982697, gi|... - gi|32413615|ref|XP_327287.1| HOMOSERINE O-ACETYLTRANSFERASE (HOMOSERINE O-TRANS-ACETYLASE) [Neurospo...
 3.0E-93 [1..486] [1..498]
MET2_ASCIM - Homoserine O-acetyltransferase OS=Ascobolus immersus GN=MET2 PE=3 SV=1
 1.0E-91 [19..486] [22..518]
met6 - homoserine O-acetyltransferase
MET2_SCHPO - Homoserine O-acetyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=met6 PE=3 S...
 4.0E-89 [18..486] [19..489]
gi|11353183 - pir||A81140 homoserine O-acetyltransferase NMB0940 [imported] - Neisseria meningitidis (strain MC58 ...
METX_NEIMB - Homoserine O-acetyltransferase OS=Neisseria meningitidis serogroup B (strain MC58) GN=metX PE=3 SV=1
METX_NEIMB - Homoserine O-acetyltransferase OS=Neisseria meningitidis serogroup B GN=metX PE=3 SV=1
 3.0E-54 [19..368] [1..372]

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Predicted Domain #1
Region A:
Residues: [1-357] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHTLKSKTL QELDIEEIKE TNPLLKLVQG QRIVQVPELV LESGVVINNF PIAYKTWGTL  60
   61 NEAGDNVLVI CHALTGSADV ADWWGPLLGN DLAFDPSRFF IICLNSMGSP YGSFSPLTIN 120
  121 EETGVRYGPE FPLCTVRDDV RAHRIVLDSL GVKSIACVIG GSMGGMLSLE WAAMYGKEYV 180
  181 KNMVALATSA RHSAWCISWS EAQRQSIYSD PNYLDGYYPV EEQPVAGLSA ARMSALLTYR 240
  241 TRNSFENKFS RRSPSIAQQQ KAQREETRKP STVSEHSLQI HNDGYKTKAS TAIAGISGQK 300
  301 GQSVVSTASS SDSLNSSTSM TSVSSVTGEV KDIKPAQTYF SAQSYLRYQG TKFINRF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.221849
Match: 1azwA_
Description: Proline iminopeptidase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.39629727416851 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.541803897301601 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [358-486] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DANCYIAITR KLDTHDLARD RVDDITEVLS TIQQPSLIIG IQSDGLFTYS EQEFLAEHIP  60
   61 KSQLEKIESP EGHDAFLLEF KLINKLIVQF LKTNCKAITD AAPRAWGGDV GNDETKTSVF 120
  121 GEAEEVTNW

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.46
Match: 1iunA
Description: Meta-cleavage product hydrolase CumD
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle