YRC Public Data Repository - Protein Structure Prediction

Protein:	MPA43
Organism:	Saccharomyces cerevisiae
Length:	542 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MPA43.

Description	E-value	Query Range	Subject Range
GLPK2_THEMA, GLK... - Glycerol kinase 2 OS=Thermotoga maritima GN=glpK2 PE=3 SV=2, (Q9X1E4) Glycerol kinase 2 (EC 2.7.1.30... GLPK2_THEMA - Glycerol kinase 2 OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) GN=glpK2 ...	0.0	[6..534]	[2..496]
gi\|7434247 - gi\|7434247\|pir\|\|C72254 glycerol kinase - Thermotoga maritima (strain MSB8) gi\|15644181, gi\|... - gi\|4981995\|gb\|AAD36500.1\|AE001795_3 glycerol kinase [Thermotoga maritima MSB8], gi\|15644181\|ref\|NP_2...	0.0	[6..509]	[2..482]
GLPK1_SULSO, GLK... - Glycerol kinase 1 OS=Sulfolobus solfataricus GN=glpK1 PE=3 SV=1, (Q97XW1) Glycerol kinase 1 (EC 2.7.... GLPK1_SULSO - Glycerol kinase 1 OS=Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) GN=glpK...	0.0	[1..535]	[1..497]
GLPK_PYRAB - Glycerol kinase OS=Pyrococcus abyssi GN=glpK PE=3 SV=1 GLPK_PYRAB - Glycerol kinase OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=glpK PE=3 SV=1	0.0	[1..535]	[1..492]
gi\|144982459 - gi\|144982459\|gb\|EDJ90025.1\| glycerol kinase [Haemophilus influenzae R3021] gi\|145271495, gi... - gi\|145639448\|ref\|ZP_01795053.1\| glycerol kinase [Haemophilus influenzae PittII], gi\|145271495\|gb\|EDK... gi\|145637622, gi... - gi\|145637622\|ref\|ZP_01793278.1\| glycerol kinase [Haemophilus influenzae PittHH], gi\|145269219\|gb\|EDK... gi\|145631898 - gi\|145631898\|ref\|ZP_01787654.1\| glycerol kinase [Haemophilus influenzae 22.4-21] GLPK_HAEIN - Glycerol kinase OS=Haemophilus influenzae GN=glpK PE=3 SV=2 gi\|42630951 - gi\|42630951\|ref\|ZP_00156489.1\| COG0554: Glycerol kinase [Haemophilus influenzae R2866] GLPK_HAEIN - Glycerol kinase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN=glpK PE=3 S... gi\|229811540, gi... - gi\|229845524\|ref\|ZP_04465652.1\| glycerol kinase [Haemophilus influenzae 6P18H1], gi\|229811540\|gb\|EEP...	0.0	[3..533]	[2..499]
GLPK_STAA2 - Glycerol kinase OS=Staphylococcus aureus (strain JH1) GN=glpK PE=3 SV=1 GLPK_STAA9 - Glycerol kinase OS=Staphylococcus aureus (strain JH9) GN=glpK PE=3 SV=1 GLPK_STAA1 - Glycerol kinase OS=Staphylococcus aureus (strain Mu3 / ATCC 700698) GN=glpK PE=3 SV=1 GLPK_STAAN - Glycerol kinase OS=Staphylococcus aureus (strain N315) GN=glpK PE=1 SV=1 gi\|269202916\|ref... - glycerol kinase [Staphylococcus aureus subsp. aureus ED98] gi\|255006086 - gi\|255006086\|ref\|ZP_05144687.2\| glycerol kinase [Staphylococcus aureus subsp. aureus Mu50-omega] GLPK_STAAM - Glycerol kinase OS=Staphylococcus aureus (strain Mu50 / ATCC 700699) GN=glpK PE=3 SV=1 gi\|25287514 - pir\|\|G89904 glycerol kinase [imported] - Staphylococcus aureus (strain N315)	0.0	[6..531]	[3..495]
GLPK_BACSU - Glycerol kinase OS=Bacillus subtilis GN=glpK PE=1 SV=1 gi\|2633252, gi\|1... - gi\|2633252\|emb\|CAB12757.1\| glycerol kinase [Bacillus subtilis subsp. subtilis str. 168], gi\|16077994...	0.0	[7..531]	[4..495]
GLPK_PASMU - Glycerol kinase OS=Pasteurella multocida GN=glpK PE=3 SV=1 GLPK_PASMU - Glycerol kinase OS=Pasteurella multocida (strain Pm70) GN=glpK PE=3 SV=1	0.0	[3..533]	[2..499]
GLPK_PYRFU - Glycerol kinase OS=Pyrococcus furiosus GN=glpK PE=3 SV=1 GLPK_PYRFU - Glycerol kinase OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) GN=glpK PE=3 ...	0.0	[7..535]	[4..489]

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Predicted Domain #1

Region A:
Residues: [1-264]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSSLQVGIG IDVGSSSARI GVYNYYNDAL LEMAQEPVPY YQDSSKKSWK FWQKSTEIIK  60
   61 ALQKCLQKLN IREYEVKSCG VSATCSLAIF ERDRTSNMLI PYPNEDNVIF WMDSSAVNEC 120
  121 QWLNMQCPQQ LLDYLGGKFV PEMGVPKLKY FLDEYSHLRD KHFHIFDLHQ YIAYELSRLY 180
  181 EWNIEGLLGR ENLNGIGNDG EVSGWSSSFY KNIINLPSNV SIGTTSLVAN KHISTTVVRS 240
  241 CIDSYASWFA VASPHLETSL FMIA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	126.0
Match:	1bo5O_
Description:	Glycerol kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.49074335090904	bayes_pls_golite062009
protein binding	0.856838411407636	bayes_pls_golite062009
catalytic activity	0.296484721581333	bayes_pls_golite062009
carbohydrate kinase activity	0.0904842102388556	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [265-313]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTSSCYMYGT TISDTRIPGV WGPFDTILDN RGDFSVYAAG QSCTGKLIE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [457-487]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVDMMGIKGA YVLAKSAKEK KQLADVITER D

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	126.0
Match:	1bo5O_
Description:	Glycerol kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [314-456]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HLFESHPCAR KILKDGADIY QVLEQTIRDI EKNNGLSIHI LTKDMFFYGD YEGNRTPFAD  60
   61 PRIKGSFIGE STDTSMLNLT YKYICILEFL SFQTKLIIDT FQNENSNIHI KELRISGSQA 120
  121 KNERLLSLIS LVNNGVAIIK PKE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [488-542]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISNDSEKFES LAEYRLGNDS ILLRKLLCVK YHIHLDMAKQ QKRYHKLVDE VFQHL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	126.0
Match:	1bo5O_
Description:	Glycerol kinase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: