YRC Public Data Repository - Protein Structure Prediction

Protein:	MRPL22
Organism:	Saccharomyces cerevisiae
Length:	309 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MRPL22.

Description	E-value	Query Range	Subject Range
MRPL22 - Mitochondrial ribosomal protein of the large subunit	0.0	[1..309]	[1..309]
RK22_PEA - 50S ribosomal protein L22, chloroplastic OS=Pisum sativum GN=rpl22 PE=2 SV=1	8.0E-46	[101..278]	[16..201]
gi\|31324951 - gi\|31324951\|gb\|AAH52940.1\| Rpl17 protein [Mus musculus] gi\|109122149, gi... - gi\|109122151\|ref\|XP_001089275.1\| PREDICTED: similar to 60S ribosomal protein L17 (L23) isoform 5 [Ma... gi\|114692313, gi... - gi\|55627436\|ref\|XP_518757.1\| PREDICTED: hypothetical protein isoform 3 [Pan troglodytes], gi\|1146923... gi\|73962160, gi\|... - gi\|73962164\|ref\|XP_861376.1\| PREDICTED: similar to 60S ribosomal protein L17 (L23) isoform 10 [Canis... RPL17 - ribosomal protein L17 ENSCJAT000000092... - null, null gi\|123982774, gi... - gi\|123997445\|gb\|ABM86324.1\| ribosomal protein L17 [synthetic construct], gi\|123982774\|gb\|ABM83128.1\|... RL17_FELCA - 60S ribosomal protein L17 OS=Felis catus GN=RPL17 PE=2 SV=3	5.0E-45	[155..282]	[7..165]
gi\|57682 - gi\|57682\|emb\|CAA41278.1\| ribosomal protein L17 [Rattus rattus] RL17_BOVIN - 60S ribosomal protein L17 OS=Bos taurus GN=RPL17 PE=2 SV=3 gi\|77415533, gi\|... - gi\|77415533\|gb\|AAI06166.1\| Ribosomal protein L17 [Mus musculus], gi\|62024644\|gb\|AAH92091.1\| Ribosoma... gi\|149720927 - gi\|149720927\|ref\|XP_001499165.1\| PREDICTED: similar to Rpl17 protein isoform 1 [Equus caballus] gi\|50806588, gi\|... - gi\|50806588\|ref\|XP_424454.1\| PREDICTED: similar to Rpl17 protein [Gallus gallus], gi\|118119614\|ref\|X... gi\|149463856 - gi\|149463856\|ref\|XP_001505494.1\| PREDICTED: similar to POU domain, class 6, transcription factor 2 [... gi\|55716080 - gb\|AAH86177.1\| Unknown (protein for MGC:98635) [Xenopus laevis] RL17_RAT - 60S ribosomal protein L17 OS=Rattus norvegicus GN=Rpl17 PE=2 SV=3 tr\|G3HMS8\|G3HMS8... - 60S ribosomal protein L17 OS=Cricetulus griseus GN=I79_012050 PE=3 SV=1 gi\|62548128, gi\|... - gi\|62548128\|gb\|AAX86695.1\| ribosomal protein L17 [Taeniopygia guttata], gi\|197127959\|gb\|ACH44457.1\| ... gi\|126320711 - gi\|126320711\|ref\|XP_001365329.1\| PREDICTED: similar to Rpl17 protein [Monodelphis domestica] tr\|G1SCJ6\|G1SCJ6... - pep:known chromosome:oryCun2:2:27709552:27710106:-1 gene:ENSOCUG00000022888 transcript:ENSOCUT000000... gi\|542163003\|ref... - PREDICTED: 60S ribosomal protein L17 [Zonotrichia albicollis]	9.0E-45	[155..282]	[7..165]
RL17_MOUSE - 60S ribosomal protein L17 OS=Mus musculus GN=Rpl17 PE=1 SV=3	9.0E-45	[155..282]	[7..165]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-44	[124..299]	[217..397]
gi\|15293901 - gi\|15293901\|gb\|AAK95143.1\|AF401571_1 ribosomal protein L17 [Ictalurus punctatus]	2.0E-44	[155..280]	[7..163]
gi\|7340070 - gi\|7340070\|gb\|AAF61071.1\|AF220552_1 ribosomal protein L17 [Paralichthys olivaceus]	2.0E-44	[155..282]	[7..165]
gi\|110735706, gi... - gi\|21553938\|gb\|AAM63019.1\| unknown [Arabidopsis thaliana], gi\|18417177\|ref\|NP_567805.1\| ribosomal pr...	3.0E-44	[81..299]	[19..246]
RK22_NICSY - 50S ribosomal protein L22, chloroplastic OS=Nicotiana sylvestris GN=rpl22 PE=3 SV=1 RK22_TOBAC - 50S ribosomal protein L22, chloroplastic OS=Nicotiana tabacum GN=rpl22 PE=3 SV=1	3.0E-39	[157..307]	[3..152]

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Predicted Domain #1

Region A:
Residues: [1-124]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNFHTARISQ VGVISRALLS SVSRRWIHVT PISLNNSGGS LFGSITENKP KEGKNRGDED  60
   61 AGSFSNRLAI ASDSSGEAPE VNRDSITIEN DKLLQQHIIS LQQPEQLASQ SLLSPLKREI 120
  121 YEAN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.435	a.24.3	Cytochromes
View	Download	0.423	d.95.2	Homing endonucleases
View	Download	0.530	d.110.4	SNARE-like
View	Download	0.411	b.82.4	Regulatory protein AraC
View	Download	0.530	d.110.4	SNARE-like
View	Download	0.435	a.24.3	Cytochromes
View	Download	0.423	d.95.2	Homing endonucleases
View	Download	0.421	a.121.1	Tetracyclin repressor-like, C-terminal domain
View	Download	0.421	a.121.1	Tetracyclin repressor-like, C-terminal domain
View	Download	0.411	b.82.4	Regulatory protein AraC
View	Download	0.406	a.24.3	Cytochromes
View	Download	0.401	a.24.3	Cytochromes
View	Download	0.381	i.11.1	Computational models partly based on NMR data
View	Download	0.368	f.1.5	Exotoxin A, middle domain
View	Download	0.366	a.74.1	Cyclin-like
View	Download	0.346	a.91.1	Regulator of G-protein signalling, RGS
View	Download	0.337	c.51.3	B12-dependend dehydatases associated subunit
View	Download	0.333	c.23.12	Formate/glycerate dehydrogenase catalytic domain-like
View	Download	0.326	a.69.1	C-terminal domain of alpha and beta subunits of F1 ATP synthase
View	Download	0.321	a.24.7	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View	Download	0.319	a.48.2	Transferrin receptor ectodomain, C-terminal domain
View	Download	0.311	a.142.1	PTS-regulatory domain, PRD
View	Download	0.301	a.26.1	4-helical cytokines
View	Download	0.281	d.52.3	Prokaryotic type KH domain (KH-domain type II)
View	Download	0.264	a.24.3	Cytochromes
View	Download	0.247	c.23.5	Flavoproteins
View	Download	0.225	a.95.1	Influenza virus matrix protein M1
View	Download	0.220	a.29.4	RecG, N-terminal domain
View	Download	0.215	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.211	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.208	d.3.1	Cysteine proteinases
View	Download	0.208	a.7.5	Tubulin chaperone cofactor A

Predicted Domain #2

Region A:
Residues: [125-309]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CKINGGFYKK DTIVKLPNSS ERYKLKFTKR EIEVLEPSVY AQSYRIKSSM KKATLLLRLL  60
   61 GGLDVMKAIS QCHFSNKKIA REVAELLQKG VKDGQKLGLK PEDLYISQIW TGSDGFWRKR 120
  121 VEFKARTRIG IISHPYIHVR CILRTKSVTK RRLAYEAHLK EQKRAPWVQL GDKPIRGVTG 180
  181 GVYKW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.0
Match:	1lnrQ_
Description:	No description for 1lnrQ_ was found.

Predicted functions:

Term	Confidence	Notes
structural constituent of ribosome	9.71138472170121	bayes_pls_golite062009
structural molecule activity	9.13471776263155	bayes_pls_golite062009
binding	1.30630421512737	bayes_pls_golite062009
protein binding	0.592567938703741	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: