YRC Public Data Repository - Protein Structure Prediction

Protein:	INN1
Organism:	Saccharomyces cerevisiae
Length:	409 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for INN1.

Description	E-value	Query Range	Subject Range
gi\|45269942 - gi\|45269942\|gb\|AAS56352.1\| YNL152W [Saccharomyces cerevisiae]	326.0	[0..1]	[409..1]
gi\|50806606 - gi\|50806606\|ref\|XP_424462.1\| PREDICTED: similar to ubiquitin-protein ligase NEDD4-like; neural precu...	314.0	[0..13]	[405..463]
gi\|119583470, gi... - gi\|21361472\|ref\|NP_056092.2\| neural precursor cell expressed, developmentally down-regulated 4-like ... gi\|114673303 - gi\|114673303\|ref\|XP_001141065.1\| PREDICTED: ubiquitin-protein ligase NEDD4-like isoform 10 [Pan trog...	298.0	[0..7]	[405..16]
NED4L_PONPY - E3 ubiquitin-protein ligase NEDD4-like protein - Pongo pygmaeus (Orangutan) NED4L_PONAB - E3 ubiquitin-protein ligase NEDD4-like OS=Pongo abelii GN=NEDD4L PE=2 SV=1	298.0	[0..5]	[405..19]
gi\|114673309 - gi\|114673309\|ref\|XP_001140893.1\| PREDICTED: ubiquitin-protein ligase NEDD4-like isoform 8 [Pan trogl... gi\|222352090 - gi\|222352090\|ref\|NP_001138441.1\| neural precursor cell expressed, developmentally down-regulated 4-l...	298.0	[0..7]	[405..8]
gi\|49257568, gi\|... - gi\|49257568\|gb\|AAH74133.1\| Nedd4 protein [Xenopus laevis], gi\|147901141\|ref\|NP_001084258.1\| Nedd4 pr...	297.0	[0..13]	[405..19]
gi\|55742240 - ref\|NP_001006727.1\| neural precursor cell expressed, developmentally down-regulated 4-like [Xenopus ... gi\|55742240, gi\|... - gi\|55742240\|ref\|NP_001006727.1\| neural precursor cell expressed, developmentally down-regulated 4-li...	296.0	[0..13]	[405..19]
gi\|109507468 - gi\|109507468\|ref\|XP_001064485.1\| PREDICTED: similar to E3 ubiquitin-protein ligase NEDD4-like protei...	294.0	[0..8]	[405..9]

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Predicted Domain #1

Region A:
Residues: [1-160]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEEVWNGNQ GILSVYVSKA RDLPNLNKLD KQNVMLRLRI AHMTRASNTL HRAGQNPVFH  60
   61 YLEKFDITPE IKPLMYVEVY CDRRKKSPLP IGRCEIDLLN AIRADPKEGY CTWYELKRSG 120
  121 DEFAGTIFIE LTFTPKVPRL NRDDLNKEMD RLDSSMAMRP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.522879
Match:	1dqvA
Description:	Synaptogamin I
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [161-284]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPPLPTESEY DYVHGSTMRQ ITPQCVSTSH EDKDEGQPYR NGNVFSMSSK SDTAVLANSN  60
   61 DPIILPPTFS ASMGTTSTLE TNDTAISNTS NTKFHFANLR KLKEKINIFK NPDSSTNNCQ 120
  121 NESN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.595	c.51.1	Anticodon-binding domain of Class II aaRS
View	Download	0.595	c.51.1	Anticodon-binding domain of Class II aaRS
View	Download	0.468	d.110.4	SNARE-like
View	Download	0.468	d.110.4	SNARE-like
View	Download	0.457	a.4.3	ARID-like
View	Download	0.427	d.58.26	GHMP Kinase, C-terminal domain
View	Download	0.407	c.23.1	CheY-like
View	Download	0.398	d.82.2	Frataxin-like
View	Download	0.398	d.82.2	Frataxin-like
View	Download	0.387	d.82.2	Frataxin-like

Predicted Domain #3

Region A:
Residues: [285-353]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVDIEALQKA IGVTSLSYDE DDDDDDENDA FYSSSHRVSH NYNQPPLPPI PTRDDMSNYS  60
   61 SSRNTPLVR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.522879
Match:	1i5hW
Description:	Ubiquitin ligase NEDD4 WWIII domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [354-409]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDRPSRLDSS SPNSHPHPSG LNSPKLPPLP TTSNSNFNSR KNSMSPTRKR PPPRLS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.280	a.189.1	Description not found.
View	Download	0.276	a.4.1	Homeodomain-like
View	Download	0.271	g.41.11	Znf265, first zinc-finger domain
View	Download	0.241	a.60.2	RuvA domain 2-like
View	Download	0.214	a.35.1	lambda repressor-like DNA-binding domains

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits