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View Structure Prediction Details

Protein: HEF3
Organism: Saccharomyces cerevisiae
Length: 1044 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HEF3.

Description E-value Query
Range
Subject
Range
HEF3 - Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates ...
EF3B_YEAST - Elongation factor 3B OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEF3 PE=1 SV=2
0.0 [1..1044] [1..1044]
gi|3786314 - gi|3786314|dbj|BAA33959.1| translation elongation factor3 [Candida glabrata]
0.0 [1..1044] [1..1045]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [2..1044] [5..1050]
EF3_CANAL - Elongation factor 3 OS=Candida albicans GN=TEF3 PE=1 SV=1
0.0 [2..1044] [5..1049]
EF3_SCHPO - Elongation factor 3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=tef3 PE=1 SV=1
tef3 - translation elongation factor eEF3
0.0 [2..1042] [5..1046]
EF3_PNECA - Elongation factor 3 OS=Pneumocystis carinii GN=TEF3 PE=3 SV=1
0.0 [1..1043] [1..1042]
gi|13442976 - gi|13442976|gb|AAK26245.1| elongation factor 3 [Cryptococcus neoformans var. neoformans]
gi|58266210, gi|... - gi|58266210|ref|XP_570261.1| elongation factor 3 [Cryptococcus neoformans var. neoformans JEC21], gi...
gi|134111046, gi... - gi|50258329|gb|EAL21018.1| hypothetical protein CNBD3940 [Cryptococcus neoformans var. neoformans B-...
0.0 [18..1042] [21..1054]

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Predicted Domain #1
Region A:
Residues: [1-321]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSQQSITV LEELFRKLET ATSETREGIS SELSSFLNGN IIEHDVPEVF FDEFQKAIQS  60
   61 KQKALNTLGA VAYIANETNL SPSVEPYIVA TVPSVCSKAG SKDNDVQLAA TKALKAIASA 120
  121 VNPVAVKALL PHLIHSLETS NKWKEKVAVL EVISVLVDAA KEQIALRMPE LIPVLSESMW 180
  181 DTKKGVKEAA TTTITKATET VDNKDIERFI PKLIECIANP NEVPETVHLL GATTFVAEVT 240
  241 PATLSIMVPL LSRGLAERET SIKRKAAVII DNMCKLVEDP QVVAPFLGKL LPGLKNNFAT 300
  301 IADPEAREVT LKALKTLRRV G

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [322-418]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVGEDDVLPE ISHAGDVSTT LGVIKELLEP EKVAPRFTIV VEYIAAIAAN LIDERIIDQQ  60
   61 TWFTHVTPYM TIFLHEKTAK EILDDFRKRA VDNIPVG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.793 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.942 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.783 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.725 a.118.12 Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain
View Download 0.725 a.118.8 TPR-like
View Download 0.713 a.24.17 Group V grass pollen allergen
View Download 0.671 a.118.1 ARM repeat
View Download 0.605 a.51.1 Cytochrome c oxidase subunit h
View Download 0.582 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.580 a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.571 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.557 a.74.1 Cyclin-like
View Download 0.549 a.77.1 DEATH domain
View Download 0.540 a.24.4 Hemerythrin
View Download 0.536 a.7.6 Ribosomal protein S20
View Download 0.520 a.61.1 Retroviral matrix proteins
View Download 0.504 a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.498 d.8.1 Urease, gamma-subunit
View Download 0.494 a.60.2 RuvA domain 2-like
View Download 0.490 a.46.1 Methionine synthase domain
View Download 0.477 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.472 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.472 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.463 a.77.1 DEATH domain
View Download 0.461 a.26.1 4-helical cytokines
View Download 0.436 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.425 d.150.1 4'-phosphopantetheinyl transferase
View Download 0.413 a.4.5 "Winged helix" DNA-binding domain
View Download 0.412 a.126.1 Serum albumin-like
View Download 0.410 a.4.5 "Winged helix" DNA-binding domain
View Download 0.395 a.77.1 DEATH domain
View Download 0.388 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.388 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.378 a.2.3 Chaperone J-domain
View Download 0.378 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.378 a.4.5 "Winged helix" DNA-binding domain
View Download 0.375 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.370 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.367 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.363 a.4.5 "Winged helix" DNA-binding domain
View Download 0.362 a.142.1 PTS-regulatory domain, PRD
View Download 0.359 a.74.1 Cyclin-like
View Download 0.352 a.24.9 alpha-catenin/vinculin
View Download 0.352 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.349 a.59.1 PAH2 domain
View Download 0.346 a.29.2 Bromodomain
View Download 0.345 a.118.9 ENTH/VHS domain
View Download 0.343 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.342 a.4.5 "Winged helix" DNA-binding domain
View Download 0.342 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.338 a.3.1 Cytochrome c
View Download 0.337 a.81.1 N-terminal domain of DnaB helicase
View Download 0.337 a.4.1 Homeodomain-like
View Download 0.334 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.333 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.332 a.24.17 Group V grass pollen allergen
View Download 0.332 a.79.1 Antitermination factor NusB
View Download 0.329 a.74.1 Cyclin-like
View Download 0.315 a.85.1 Hemocyanin, N-terminal domain
View Download 0.311 a.29.4 RecG, N-terminal domain
View Download 0.311 a.16.1 S15/NS1 RNA-binding domain
View Download 0.307 a.24.3 Cytochromes
View Download 0.306 a.133.1 Phospholipase A2, PLA2
View Download 0.306 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.300 a.118.13 Arp2/3 complex 16 kDa subunit ARPC5
View Download 0.299 a.39.1 EF-hand
View Download 0.299 a.118.1 ARM repeat
View Download 0.295 d.55.1 Ribosomal protein L22
View Download 0.292 a.47.2 t-snare proteins
View Download 0.289 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.286 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.286 d.226.1 GIY-YIG endonuclease
View Download 0.284 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.283 a.4.7 Ribosomal protein L11, C-terminal domain
View Download 0.279 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.279 a.7.1 Spectrin repeat
View Download 0.276 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.274 a.2.3 Chaperone J-domain
View Download 0.273 a.89.1 Methyl-coenzyme M reductase alpha and beta chain C-terminal domain
View Download 0.272 a.5.4 Elongation factor TFIIS domain 2
View Download 0.272 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.270 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.266 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.261 i.1.1 Ribosome and ribosomal fragments
View Download 0.259 a.64.1 Saposin
View Download 0.258 a.118.8 TPR-like
View Download 0.258 d.189.1 PX domain
View Download 0.257 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.246 d.58.26 GHMP Kinase, C-terminal domain
View Download 0.244 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.244 a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.242 a.7.1 Spectrin repeat
View Download 0.240 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.239 a.61.1 Retroviral matrix proteins
View Download 0.237 c.3.1 FAD/NAD(P)-binding domain
View Download 0.237 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.235 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.231 a.118.1 ARM repeat
View Download 0.230 a.26.1 4-helical cytokines
View Download 0.230 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.229 f.23.16 Subunit III of photosystem I reaction centre, PsaF
View Download 0.227 d.79.1 YjgF-like
View Download 0.226 a.85.1 Hemocyanin, N-terminal domain
View Download 0.226 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.223 a.112.1 Description not found.
View Download 0.216 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.212 a.71.2 Helical domain of Sec23/24
View Download 0.211 a.118.11 Cytochrome c oxidase subunit E
View Download 0.210 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.210 d.68.6 DNA-binding protein Sso10b (AlbA)
View Download 0.209 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.209 a.116.1 GTPase activation domain, GAP
View Download 0.208 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.206 a.130.1 Chorismate mutase II
View Download 0.206 d.29.1 Ribosomal protein L31e
View Download 0.204 d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.203 a.39.1 EF-hand
View Download 0.202 a.23.3 Methane monooxygenase hydrolase, gamma subunit
View Download 0.201 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.200 a.28.3 Retrovirus capsid protein C-terminal domain

Predicted Domain #3
Region A:
Residues: [419-645]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNFQDEEDEG EDLCNCEFSL AYGAKILLNK TQLRLKRGRR YGLCGPNGAG KSTLMRSIAN  60
   61 GQVDGFPTQD ECRTVYVEHD IDNTHSDMSV LDFVYSGNVG TKDVITSKLK EFGFSDEMIE 120
  121 MPIASLSGGW KMKLALARAV LKDADILLLD EPTNHLDTVN VEWLVNYLNT CGITSVIVSH 180
  181 DSGFLDKVCQ YIIHYEGLKL RKYKGNLSEF VQKCPTAQSY YELGASD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 93.383689
Match: 1b0uA_
Description: ATP-binding subunit of the histidine permease
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [646-1044]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEFQFPTPGY LEGVKTKQKA IVKVSNMTFQ YPGTTKPQVS DVTFQCSLSS RIAVIGPNGA  60
   61 GKSTLINVLT GELLPTSGEV YTHENCRIAY IKQHAFAHIE SHLDKTPSEY IQWRFQTGED 120
  121 RETMDRANRQ INENDAEAMN KIFKIEGTPR RVAGIHSRRK FKNTYEYECS FLLGENIGMK 180
  181 SERWVPMMSV DNAWLPRGEL IESHSKMVAE IDMKEALASG QFRALTRKEI ELHCAMLGLD 240
  241 SELVSHSRIR GLSGGQKVKL VLAACTWQRP HLIVLDEPTN YLDRDSLGAL SKALKAFEGG 300
  301 VIIITHSAEF TKNLTDEVWA VKDGKMTPSG HNWVAGQGAG PRIEKKEEEG DKFDAMGNKI 360
  361 NSGKKKSKLS SAELRKKKKE RMKKKKEMGD EYVSSDEDF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle