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View Structure Prediction Details

Protein: LCB1
Organism: Saccharomyces cerevisiae
Length: 558 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LCB1.

Description E-value Query
Range
Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..558] [1..558]
LCB1_YEAST - Serine palmitoyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LCB1 PE=1 ...
LCB1 - Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step ...
gi|190408522 - gi|190408522|gb|EDV11787.1| serine palmitoyltransferase component [Saccharomyces cerevisiae RM11-1a]
gi|151946004 - gi|151946004|gb|EDN64236.1| serine palmitoyltransferase component [Saccharomyces cerevisiae YJM789]
gi|207342048 - gi|207342048|gb|EDZ69929.1| YMR296Cp-like protein [Saccharomyces cerevisiae AWRI1631]
0.0 [1..558] [1..558]
HEM0_DELLE - 5-aminolevulinate synthase, erythroid-specific, mitochondrial OS=Delphinapterus leucas GN=ALAS2 PE=2...
0.0 [30..493] [75..539]
gi|202860 - gi|202860|gb|AAA40724.1| delta-aminolevulinate synthase precursor (EC 2.3.1.37)
0.0 [72..493] [175..600]
gi|28586 - gi|28586|emb|CAA39795.1| delta-aminolevulinate synthase (erythroid) [Homo sapiens]
0.0 [30..493] [75..539]
HEM0_OPSTA - 5-aminolevulinate synthase, erythroid-specific, mitochondrial OS=Opsanus tau GN=alas2 PE=2 SV=1
0.0 [38..497] [100..543]
lcb2 - serine palmitoyltransferase
LCB2_SCHPO - Serine palmitoyltransferase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=lcb2 PE=3 SV...
0.0 [6..527] [49..589]
HEM0_DANRE - 5-aminolevulinate synthase, erythroid-specific, mitochondrial OS=Danio rerio GN=alas2 PE=2 SV=1
0.0 [29..493] [79..539]
gi|4433548 - gi|4433548|gb|AAD20809.1| 5-aminolevulinate synthase [Strongylocentrotus droebachiensis]
0.0 [69..524] [114..584]

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Predicted Domain #1
Region A:
Residues: [1-85]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAHIPEVLPK SIPIPAFIVT TSSYLWYYFN LVLTQIPGGQ FIVSYIKKSH HDDPYRTTVE  60
   61 IGLILYGIIY YLSKPQQKKS LQAQK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.511 a.39.1 EF-hand
View Download 0.632 a.77.1 DEATH domain
View Download 0.569 d.201.1 SRP19
View Download 0.689 a.5.6 Hypothetical protein MTH1615
View Download 0.455 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.429 a.77.1 DEATH domain
View Download 0.395 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.382 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.373 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.348 a.77.1 DEATH domain
View Download 0.338 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.337 a.64.1 Saposin
View Download 0.336 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.334 a.39.1 EF-hand
View Download 0.321 f.28.1 Nonheme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.306 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.304 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.303 a.133.1 Phospholipase A2, PLA2
View Download 0.298 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.286 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.271 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.266 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.263 a.4.5 "Winged helix" DNA-binding domain
View Download 0.262 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.257 d.91.1 N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
View Download 0.253 a.118.8 TPR-like
View Download 0.252 d.54.1 Enolase N-terminal domain-like
View Download 0.244 a.7.6 Ribosomal protein S20
View Download 0.243 a.39.1 EF-hand
View Download 0.240 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.236 a.112.1 Description not found.
View Download 0.235 d.195.1 YopH tyrosine phosphatase N-terminal domain
View Download 0.235 a.39.1 EF-hand
View Download 0.232 a.4.3 ARID-like
View Download 0.226 a.64.1 Saposin
View Download 0.226 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.220 a.130.1 Chorismate mutase II
View Download 0.219 a.158.1 F-box domain
View Download 0.211 c.15.1 BRCT domain
View Download 0.209 a.64.1 Saposin
View Download 0.207 d.8.1 Urease, gamma-subunit
View Download 0.206 a.144.2 Ribosomal protein L20
View Download 0.205 d.235.1 Hypothetical protein Yhr087W
View Download 0.203 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.201 a.24.17 Group V grass pollen allergen
View Download 0.200 a.50.1 Anaphylotoxins (complement system)

Predicted Domain #2
Region A:
Residues: [86-153]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNLSPQEIDA LIEDWEPEPL VDPSATDEQS WRVAKTPVTM EMPIQNHITI TRNNLQEKYT  60
   61 NVFNLASN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [412-558]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLQKLSKSLH DSFASDDSLR SYVIVTSSPV SAVLHLQLTP AYRSRKFGYT CEQLFETMSA  60
   61 LQKKSQTNKF IEPYEEEEKF LQSIVDHALI NYNVLITRNT IVLKQETLPI VPSLKICCNA 120
  121 AMSPEELKNA CESVKQSILA CCQESNK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 309.741366
Match: 1fc4A_
Description: 2-amino-3-ketobutyrate CoA ligase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [154-411]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFLQLSATEP VKEVVKTTIK NYGVGACGPA GFYGNQDVHY TLEYDLAQFF GTQGSVLYGQ  60
   61 DFCAAPSVLP AFTKRGDVIV ADDQVSLPVQ NALQLSRSTV YYFNHNDMNS LECLLNELTE 120
  121 QEKLEKLPAI PRKFIVTEGI FHNSGDLAPL PELTKLKNKY KFRLFVDETF SIGVLGATGR 180
  181 GLSEHFNMDR ATAIDITVGS MATALGSTGG FVLGDSVMCL HQRIGSNAYC FSACLPAYTV 240
  241 TSVSKVLKLM DSNNDAVQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 309.741366
Match: 1fc4A_
Description: 2-amino-3-ketobutyrate CoA ligase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle