YRC Public Data Repository - Protein Structure Prediction

Protein:	PGM3
Organism:	Saccharomyces cerevisiae
Length:	622 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PGM3.

Description	E-value	Query Range	Subject Range
PGM3 - Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcr... gi\|190408504 - gi\|190408504\|gb\|EDV11769.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a] gi\|207342069 - gi\|207342069\|gb\|EDZ69947.1\| YMR278Wp-like protein [Saccharomyces cerevisiae AWRI1631] PGM3_YEAST - Phosphoribomutase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRM15 PE=1 SV=1	0.0	[1..622]	[1..622]
gi\|220951026 - gi\|220951026\|gb\|ACL88056.1\| Pmm45A-PA [synthetic construct] Pmm45A-PA - The gene Phosphomannomutase 45A is referred to in FlyBase by the symbol Dmel\Pmm45A (CG8073, FBgn003...	0.0	[2..621]	[12..621]
gi\|16552038 - gi\|16552038\|dbj\|BAB71227.1\| unnamed protein product [Homo sapiens]	0.0	[1..619]	[13..618]
gi\|12852111 - gi\|12852111\|dbj\|BAB29278.1\| unnamed protein product [Mus musculus]	0.0	[10..621]	[6..604]
PGM3_SCHPO - Probable phosphoribomutase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC1840.05c PE... SPCC1840.05c - phosphomannomutase	0.0	[10..619]	[2..585]
gi\|18310855, gi\|... - gi\|18310855\|ref\|NP_562789.1\| phosphomannomutase [Clostridium perfringens str. 13], gi\|18145537\|dbj\|B... gi\|170713659, gi... - gi\|170713659\|gb\|EDT25841.1\| phosphoglucomutase/phosphomannomutase family protein [Clostridium perfri...	0.0	[14..608]	[3..568]
gi\|16804513 - gi\|16804513\|ref\|NP_465998.1\| hypothetical protein lmo2475 [Listeria monocytogenes EGD-e] gi\|25331905, gi\|... - pir\|\|AC1384 phosphomannomutase and phosphoglucomutase homolog lmo2475 [imported] - Listeria monocyto...	0.0	[14..610]	[4..574]

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Predicted Domain #1

Region A:
Residues: [1-224]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLQGILETVP SDLKDPISLW FKQDRNPKTI EEVTALCKKS DWNELHKRFD SRIQFGTAGL  60
   61 RSQMQAGFSR MNTLVVIQAS QGLATYVRQQ FPDNLVAVVG HDHRFHSKEF ARATAAAFLL 120
  121 KGFKVHYLNP DHEFVHTPLV PFAVDKLKAS VGVMITASHN PKMDNGYKVY YSNGCQIIPP 180
  181 HDHAISDSID ANLEPWANVW DFDDVLNKAL KQGKLMYSRE EMLK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	155.228787
Match:	1c47A_
Description:	Phosphoglucomutase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.61980820714401	bayes_pls_golite062009
intramolecular transferase activity, phosphotransferases	0.9938893438261	bayes_pls_golite062009
phosphomannomutase activity	0.96914970670646	bayes_pls_golite062009
catalytic activity	0.792640318995558	bayes_pls_golite062009
isomerase activity	0.340395019264179	bayes_pls_golite062009
phosphoglucomutase activity	0.268745464529951	bayes_pls_golite062009
protein binding	0.259532204752794	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [225-345]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYLEEVSKNL VEINPLKLEV KAKPWFVYTP MHGVGFDIFS TIVKKTLCLV EGKDYLCVPE  60
   61 QQNPDPSFPT VGFPNPEEKG ALDIGINLAE KHDIDLLVAN DPDADRFSVA VKDMQSGEWR 120
  121 Q

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [437-468]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AMEHDKDGIS ASIVFLQAYC KWKIDHNLDP LN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	155.228787
Match:	1c47A_
Description:	Phosphoglucomutase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [346-436]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTGNEIGFLF AFYEYQKYKS MDKEFQHVHP LAMLNSTVSS QMIKKMAEIE GFHYEDTLTG  60
   61 FKWIGNRAIL LEKKGYYVPF GFEEAIGYMF P

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [469-479]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLENGFKKYG V

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [538-549]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INHKPTLPVD PT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	155.228787
Match:	1c47A_
Description:	Phosphoglucomutase
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [480-537]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FKEYNGYYVV PNPTVTKDIF DYIRNVYTPE GASYPSSIGE EIEVLYYRDL TTGYQSDT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [550-622]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQMITVSARP SNGSENEHIR FTIRGSGTEP KLKVYIEACA NEEQRASFLA KLTWNVLRRE  60
   61 WFRPDEMNIV TKF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	155.228787
Match:	1c47A_
Description:	Phosphoglucomutase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: