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View Structure Prediction Details

Protein: SKY1
Organism: Saccharomyces cerevisiae
Length: 742 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SKY1.

Description E-value Query
Range
Subject
Range
SKY1 - SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation home...
SKY1_YEAST - Serine/threonine-protein kinase SKY1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SKY...
0.0 [1..742] [1..742]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [6..734] [365..1050]
SRPK1 - SFRS protein kinase 1
0.0 [89..707] [182..825]
gi|17386090 - gi|17386090|gb|AAL38593.1|AF446079_1 SR protein kinase 1 [Cricetulus longicaudatus]
0.0 [89..707] [8..645]
SRPK1_MOUSE - SRSF protein kinase 1 OS=Mus musculus GN=Srpk1 PE=1 SV=2
gi|117616836 - gi|117616836|gb|ABK42436.1| SRPK-1 [synthetic construct]
0.0 [89..707] [11..647]
gi|10242347 - gi|10242347|gb|AAG15387.1|AF301149_1 SR protein kinase 1 [Drosophila melanogaster]
0.0 [8..707] [33..764]

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Predicted Domain #1
Region A:
Residues: [1-129]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSSINYPGF VTKSAHLADT STDASISCEE ATSSQEAKKN FFQRDYNMMK KAPAPTKSKL  60
   61 SLALQTSKSS SSANGTVQED TSSKTEDFST KSIKKKPDSG VESHVSIQSD SGPQSDSDLD 120
  121 SDSSISSCD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.376 0.954 positive regulation of protein import into nucleus c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.376 0.954 positive regulation of protein import into nucleus c.37.1 P-loop containing nucleoside triphosphate hydrolases

Predicted Domain #2
Region A:
Residues: [130-372]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERNEESLKDY RPGGYHPAFK GEPYKDARYI LVRKLGWGHF STVWLAKDMV NNTHVAMKIV  60
   61 RGDKVYTEAA EDEIKLLQRV NDADNTKEDS MGANHILKLL DHFNHKGPNG VHVVMVFEVL 120
  121 GENLLALIKK YEHRGIPLIY VKQISKQLLL GLDYMHRRCG IIHTDIKPEN VLMEIGDVEG 180
  181 IVQMVEALDK QKREAKRLQR HVSRSSDITA NDSSDEKWAE CQTSMPCGSS SNSKSRSIEK 240
  241 DLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.134302
Match: 1ckiA_
Description: Casein kinase-1, CK1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [373-424]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRCFRRPRRH TIITGSQPLP SPISSSNFFE MRAHFCGSSH NSFSSVSGNR NI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.330 b.71.1 Glycosyl hydrolase domain
View Download 0.227 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.202 d.68.3 SirA-like
View Download 0.317 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase

Predicted Domain #4
Region A:
Residues: [425-469]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSSINNNSIN NGIGIKNSNN SFLNSVPHSV TRMFINEDSN DNNNN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [488-503]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDIMNTPLHE EQLADS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1377.69897
Match: 1howA_
Description: Sky1p
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [470-487]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNSKNKNNNN NNSNNNNN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [504-560]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSTFDISNIS QSSDTNGPYI SNTMDSNSNV STDINSPENL IQIKIADLGN ACWYDEH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1377.69897
Match: 1howA_
Description: Sky1p
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [561-742]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTNSIQTREY RSPEVLLGAP WGCGADIWST ACLIFELITG DFLFEPDEGH SYTKDDDHIA  60
   61 QIIELLGELP SYLLRNGKYT RTFFNSRGLL RNISKLKFWP LEDVLTEKYK FSKDEAKEIS 120
  121 DFLSPMLQLD PRKRADAGGL VNHPWLKDTL GMEEIRVPDR ELYGSGSDIP GWFEEVRDHK 180
  181 RH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1377.69897
Match: 1howA_
Description: Sky1p
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle