YRC Public Data Repository - Protein Structure Prediction

Protein:	HSC82
Organism:	Saccharomyces cerevisiae
Length:	705 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HSC82.

Description	E-value	Query Range	Subject Range
HS90A_RAT - Heat shock protein HSP 90-alpha OS=Rattus norvegicus GN=Hsp90aa1 PE=1 SV=3	0.0	[2..705]	[16..733]
HS90A_MOUSE - Heat shock protein HSP 90-alpha OS=Mus musculus GN=Hsp90aa1 PE=1 SV=4	0.0	[2..705]	[16..733]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[2..705]	[15..728]
HS90A_PIG - Heat shock protein HSP 90-alpha OS=Sus scrofa GN=HSP90AA1 PE=2 SV=3	0.0	[2..705]	[16..733]
gi\|123678, gi\|40... - gi\|40254816\|ref\|NP_005339.2\| heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2 ...	0.0	[2..705]	[16..732]
HS90B_CHICK - Heat shock cognate protein HSP 90-beta OS=Gallus gallus GN=HSP90AB1 PE=2 SV=1	0.0	[2..705]	[11..725]
HS9A_HORSE, HS90... - (Q9GKX7) Heat shock protein HSP 90-alpha (HSP 86) (Fragment), Heat shock protein HSP 90-alpha (Fragm...	0.0	[2..702]	[5..719]
HS90A_BRARE, HS9... - (Q90474) Heat shock protein HSP 90-alpha, (Q90474) Heat shock protein HSP 90-alpha	0.0	[2..705]	[14..726]
HS90A_CRIGR - Heat shock protein HSP 90-alpha OS=Cricetulus griseus GN=HSP90AA1 PE=2 SV=2	0.0	[2..705]	[16..733]

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Predicted Domain #1

Region A:
Residues: [1-220]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGETFEFQA EITQLMSLII NTVYSNKEIF LRELISNASD ALDKIRYQAL SDPKQLETEP  60
   61 DLFIRITPKP EEKVLEIRDS GIGMTKAELI NNLGTIAKSG TKAFMEALSA GADVSMIGQF 120
  121 GVGFYSLFLV ADRVQVISKN NEDEQYIWES NAGGSFTVTL DEVNERIGRG TVLRLFLKDD 180
  181 QLEYLEEKRI KEVIKRHSEF VAYPIQLLVT KEVEKEVPIP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1204.0
Match:	1a4h__
Description:	HSP90
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [221-705]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEEKKDEEKK DEDDKKPKLE EVDEEEEEKK PKTKKVKEEV QELEELNKTK PLWTRNPSDI  60
   61 TQEEYNAFYK SISNDWEDPL YVKHFSVEGQ LEFRAILFIP KRAPFDLFES KKKKNNIKLY 120
  121 VRRVFITDEA EDLIPEWLSF VKGVVDSEDL PLNLSREMLQ QNKIMKVIRK NIVKKLIEAF 180
  181 NEIAEDSEQF DKFYSAFAKN IKLGVHEDTQ NRAALAKLLR YNSTKSVDEL TSLTDYVTRM 240
  241 PEHQKNIYYI TGESLKAVEK SPFLDALKAK NFEVLFLTDP IDEYAFTQLK EFEGKTLVDI 300
  301 TKDFELEETD EEKAEREKEI KEYEPLTKAL KDILGDQVEK VVVSYKLLDA PAAIRTGQFG 360
  361 WSANMERIMK AQALRDSSMS SYMSSKKTFE ISPKSPIIKE LKKRVDEGGA QDKTVKDLTN 420
  421 LLFETALLTS GFSLEEPTSF ASRINRLISL GLNIDEDEET ETAPEASTEA PVEEVPADTE 480
  481 MEEVD

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	1000.0
Match:	PF00183
Description:	Hsp90 protein

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits