YRC Public Data Repository - Protein Structure Prediction

Protein:	SEC59
Organism:	Saccharomyces cerevisiae
Length:	519 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEC59.

Description	E-value	Query Range	Subject Range
SEC59_YEAST - Dolichol kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC59 PE=1 SV=1 SEC59 - Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; require...	0.0	[1..519]	[1..519]
gi\|19075483 - gi\|19075483\|ref\|NP_587983.1\| hypothetical protein SPCC63.10c [Schizosaccharomyces pombe 972h-] SPCC63.10c - dolichol kinase	6.0E-81	[122..512]	[57..459]
gi\|18389248 - gi\|18389248\|gb\|AAL67067.1\| unknown protein [Arabidopsis thaliana]	2.0E-80	[123..508]	[155..561]
CG8311-PA - This gene is referred to in FlyBase by the symbol Dmel\CG8311 (CG8311, FBgn0034141). It is a protein...	2.0E-77	[137..508]	[90..494]
gi\|114627080 - gi\|114627080\|ref\|XP_001162301.1\| PREDICTED: transmembrane protein 15 [Pan troglodytes] DOLK - dolichol kinase gi\|168269680 - gi\|168269680\|dbj\|BAG09967.1\| transmembrane protein 15 [synthetic construct]	6.0E-66	[136..503]	[158..525]
gi\|16944701 - gi\|16944701\|emb\|CAC28826.2\| conserved hypothetical protein [Neurospora crassa]	9.0E-44	[294..464]	[822..1015]
gi\|2622200, gi\|1... - gi\|2622200\|gb\|AAB85588.1\| conserved protein [Methanothermobacter thermautotrophicus str. Delta H], g... gi\|7482080 - pir\|\|A69013 conserved hypothetical protein MTH1099 - Methanobacterium thermoautotrophicum (strain De...	1.0E-33	[287..505]	[19..229]

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Predicted Domain #1

Region A:
Residues: [1-59]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAIIPHASF TTIKLTQKTE GSQMPTEEIC KINMRTRKFD VGGNSRDFEC FYSNFVQTV

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.19
Match:	1k04A
Description:	FAT domain of focal adhesion kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [60-66]

      1          11         21         31         41         51         
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    1 ILLGTFF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [87-204]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IFVNVFVVCL IMVGLIFTKY WQHGYKSLPK FDTIYSLYLP FMVSLLFDTS STVINTILIL  60
   61 SVLNSYRWRT QLVVIILQLC LIFFNFEAGD RLKNIISIVI NSLLSLILKY IGQLKSLD

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.29
Match:	1n1bA
Description:	(+)-bornyl diphosphate synthase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [67-86]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YCVERLQPWS IVTADISYKQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [205-383]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIDSNLFSIL LTNILYVSEA GTVHFRILKG IILALTTIIS INYVLKKVMH FKPFMLSISF  60
   61 AIGLPLFANT FIHLEDGENP LLWLVKYILE STIRQKILFA WSSILILSIP SILIEKDSLS 120
  121 LNTSRKLWHF IIFLLIIPSF QMDSNFVKIA LSGTIPVFLS IEYIRFQNLP PLGSAIELQ

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.29
Match:	1n1bA
Description:	(+)-bornyl diphosphate synthase
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [384-519]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRRFADDRDH SGPLIISYLY LLFGISTPLL MNNSPMGLIG LGIGDSLASI IGKRYGRIRW  60
   61 KGTQKTLEGT LAFIVTSFIV CLVLLRFDKA AIFNHLTTLQ LLTLCTLSGV LEGNSVLNDN 120
  121 ILIPAFMMIC EKLITL

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	41.431798
Match:	PF01879
Description:	No description for PF01879 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits