YRC Public Data Repository - Protein Structure Prediction

Protein:	ATR1
Organism:	Saccharomyces cerevisiae
Length:	542 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATR1.

Description	E-value	Query Range	Subject Range
ATR1_YEAST - Aminotriazole resistance protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATR1 PE... gi\|151946047 - gi\|151946047\|gb\|EDN64278.1\| aminotriazole resistance protein [Saccharomyces cerevisiae YJM789] gi\|190408131 - gi\|190408131\|gb\|EDV11396.1\| aminotriazole resistance protein [Saccharomyces cerevisiae RM11-1a] ATR1 - Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole...	2.0E-85	[1..542]	[1..542]
gi\|25498023 - pir\|\|D96902 MDR-type permease [imported] - Clostridium acetobutylicum gi\|15893318, gi\|... - gi\|15893318\|ref\|NP_346667.1\| MDR-type permease [Clostridium acetobutylicum ATCC 824], gi\|15022839\|gb...	3.0E-77	[66..491]	[4..418]
lcl\|NC_016856.1_... - [gene=emrB] [protein=putative multidrug transport protein] [protein_id=YP_005238915.1] [location=298... gi\|16766126, gi\|... - gi\|16766126\|ref\|NP_461741.1\| putative multidrug transport protein [Salmonella typhimurium LT2], gi\|1... gi\|167992539, gi... - gi\|205329344\|gb\|EDZ16108.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica sero...	6.0E-76	[65..502]	[9..438]
gi\|16761596 - gi\|16761596\|ref\|NP_457213.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|25306158, gi\|... - gi\|25306158\|pir\|\|AG0842 multidrug resistance protein B [imported] - Salmonella enterica subsp. enter... gi\|29138709, gi\|... - gi\|29143076\|ref\|NP_806418.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|213850377 - gi\|213850377\|ref\|ZP_03381275.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ... gi\|214000013 - gi\|214000013\|ref\|ZP_03410748.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ...	1.0E-75	[65..502]	[9..438]
gi\|21225257, gi\|... - gi\|7649556\|emb\|CAB89031.1\| putative membrane transport protein. [Streptomyces coelicolor A3(2)], gi\|...	5.0E-75	[47..495]	[10..448]
gi\|229896373, gi... - gi\|229896373\|ref\|ZP_04511542.1\| multidrug resistance protein B [Yersinia pestis Pestoides A], gi\|229... gi\|229899449, gi... - gi\|229899449\|ref\|ZP_04514592.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|165926632, gi... - gi\|165926632\|ref\|ZP_02222464.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|22124829, gi\|... - gi\|22124829\|ref\|NP_668252.1\| multidrug resistance protein B [Yersinia pestis KIM], gi\|21957657\|gb\|AA... gi\|166213072, gi... - gi\|166213072\|ref\|ZP_02239107.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|25306154 - pir\|\|AB0397 multidrug resistance protein B [imported] - Yersinia pestis (strain CO92) gi\|165990079, gi... - gi\|166011079\|ref\|ZP_02231977.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|51595205, gi\|... - gi\|51595205\|ref\|YP_069396.1\| MFS multidrug efflux pump, emrB subunit [Yersinia pseudotuberculosis IP... gi\|45435371, gi\|... - gi\|45440514\|ref\|NP_992053.1\| multidrug resistance protein B [Yersinia pestis biovar Microtus str. 91... gi\|218930293, gi... - gi\|218930293\|ref\|YP_002348168.1\| multidrug resistance protein B [Yersinia pestis CO92], gi\|16123425\|... gi\|149364891, gi... - gi\|149364891\|ref\|ZP_01886926.1\| multidrug resistance protein B [Yersinia pestis CA88-4125], gi\|14929... gi\|145211859, gi... - gi\|145600163\|ref\|YP_001164239.1\| multidrug resistance protein B [Yersinia pestis Pestoides F], gi\|14... gi\|167421612, gi... - gi\|167421612\|ref\|ZP_02313365.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|167051986, gi... - gi\|167399482\|ref\|ZP_02305006.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|170025556, gi... - gi\|170025556\|ref\|YP_001722061.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|167057491, gi... - gi\|167423321\|ref\|ZP_02315074.1\| multidrug resistance protein B [Yersinia pestis biovar Mediaevalis s... gi\|162354357, gi... - gi\|77633286\|ref\|ZP_00795425.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... gi\|89103813, gi\|... - gi\|89103813\|ref\|ZP_01176376.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... Q66E38\|Q66E38_YERPS - MFS multidrug efflux pump, emrB subunit - Yersinia pseudotuberculosis gi\|186894223, gi... - gi\|186894223\|ref\|YP_001871335.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|153950510, gi... - gi\|77631828\|ref\|ZP_00794414.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pse... gi\|108808750, gi... - gi\|108808750\|ref\|YP_652666.1\| multidrug resistance protein B [Yersinia pestis Antiqua], gi\|108780663... gi\|229901211, gi... - gi\|229901211\|ref\|ZP_04516333.1\| multidrug resistance protein B [Yersinia pestis Nepal516], gi\|229681... gi\|229695246, gi... - gi\|229838880\|ref\|ZP_04459039.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st...	9.0E-75	[57..502]	[1..437]
gi\|15927932, gi\|... - gi\|15927932\|ref\|NP_375465.1\| hypothetical protein SA2142 [Staphylococcus aureus subsp. aureus N315],... gi\|253314692 - gi\|253314692\|ref\|ZP_04837905.1\| hypothetical protein SauraC_00665 [Staphylococcus aureus subsp. aure... gi\|12003106, gi\|... - pir\|\|C90035 hypothetical protein SA2142 [imported] - Staphylococcus aureus (strain N315), gi\|120031... gi\|255007128 - gi\|255007128\|ref\|ZP_05145729.2\| hypothetical protein SauraM_11685 [Staphylococcus aureus subsp. aure... gi\|14248126, gi\|... - gi\|15925342\|ref\|NP_372876.1\| multidrug resistance protein [Staphylococcus aureus subsp. aureus Mu50]... gi\|269203983\|ref... - EmrB/QacA family drug resistance transporter [Staphylococcus aureus subsp. aureus ED98] gi\|90583610, gi\|... - gi\|90583610\|ref\|ZP_01239364.1\| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu... gi\|147741858, gi... - gi\|90585929\|ref\|ZP_01241634.1\| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu... gi\|156980667, gi... - gi\|156980667\|ref\|YP_001442926.1\| hypothetical protein SAHV_2336 [Staphylococcus aureus subsp. aureus...	5.0E-73	[22..481]	[91..540]
gi\|124528057, gi... - gi\|124528057\|ref\|ZP_01699410.1\| drug resistance transporter, EmrB/QacA subfamily [Escherichia coli B... EG11439 - multidrug efflux system protein / EmrAB-TolC multidrug resistance pump; energy-dependent efflux of o... gi\|189362003, gi... - gi\|189362003\|gb\|EDU80422.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4486], g... gi\|189367267, gi... - gi\|189367267\|gb\|EDU85683.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4501], g... gi\|168778668, gi... - gi\|189003608\|gb\|EDU72594.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4076], g... gi\|187769639, gi... - gi\|187769639\|gb\|EDU33483.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4196], g... gi\|189377146, gi... - gi\|189377146\|gb\|EDU95562.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC508], gi... gi\|189372123, gi... - gi\|189372123\|gb\|EDU90539.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC869], gi... gi\|169890103, gi... - gi\|170082268\|ref\|YP_001731588.1\| multidrug efflux system protein [Escherichia coli str. K-12 substr.... gi\|170019063, gi... - gi\|170019063\|ref\|YP_001724017.1\| EmrB/QacA family drug resistance transporter [Escherichia coli ATCC... gi\|1800071, gi\|8... - gi\|89109478\|ref\|AP_003258.1\| multidrug efflux system protein [Escherichia coli str. K-12 substr. W31... gi\|15832802, gi\|... - gi\|15832802\|ref\|NP_311575.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. Sakai], g... gi\|189357296, gi... - gi\|189357296\|gb\|EDU75715.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4401], g... gi\|188014965, gi... - gi\|188014965\|gb\|EDU53087.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4113], g... gi\|218706185, gi... - gi\|218706185\|ref\|YP_002413704.1\| multidrug efflux system protein [Escherichia coli UMN026], gi\|21843... gi\|218353014, gi... - gi\|218696282\|ref\|YP_002403949.1\| multidrug efflux system protein [Escherichia coli 55989], gi\|218353... gi\|238861814, gi... - gi\|238901828\|ref\|YP_002927624.1\| multidrug efflux system protein [Escherichia coli BW2952], gi\|23886... gi\|251785975, gi... - gi\|251785975\|ref\|YP_003000279.1\| hypothetical protein B21_02506 [Escherichia coli BL21], gi\|24237824... gi\|253978690, gi... - gi\|254289383\|ref\|YP_003055131.1\| multidrug efflux system protein [Escherichia coli BL21(DE3)], gi\|25... gi\|253974523, gi... - gi\|254162622\|ref\|YP_003045730.1\| multidrug efflux system protein [Escherichia coli B str. REL606], g... gi\|254594032, gi... - gi\|254794632\|ref\|YP_003079469.1\| multidrug efflux system protein [Escherichia coli O157:H7 str. TW14... EMRB_ECO57 - Multidrug export protein EmrB OS=Escherichia coli O157:H7 GN=emrB PE=3 SV=1 gi\|195938439 - gi\|195938439\|ref\|ZP_03083821.1\| membrane translocase [Escherichia coli O157:H7 str. EC4024] EG11439 - multidrug efflux system protein / EmrAB-TolC multidrug resistance pump; energy-dependent efflux of o... gi\|194427903, gi... - gi\|194427903\|ref\|ZP_03060449.1\| multidrug resistance protein B [Escherichia coli B171], gi\|194414136... gi\|208811845, gi... - gi\|208811845\|ref\|ZP_03253174.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4045... gi\|208726552, gi... - gi\|208806751\|ref\|ZP_03249088.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4206... gi\|209396264, gi... - gi\|209396264\|ref\|YP_002272153.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC411... gi\|208741288, gi... - gi\|208821165\|ref\|ZP_03261485.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4042... gi\|217319664, gi... - gi\|217327297\|ref\|ZP_03443380.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. TW1458... gi\|209920130, gi... - gi\|209920130\|ref\|YP_002294214.1\| multidrug resistance protein [Escherichia coli SE11], gi\|209913389\|... gi\|194439446, gi... - gi\|83585148\|ref\|ZP_00923799.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|157077975, gi... - gi\|75187410\|ref\|ZP_00700677.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|157162137, gi... - gi\|75196666\|ref\|ZP_00706736.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|75229766, gi\|... - gi\|75229766\|ref\|ZP_00716296.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|193071001, gi... - gi\|75234098\|ref\|ZP_00718509.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|188486943, gi... - gi\|75513256\|ref\|ZP_00735698.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... EMRB_ECOLI - Multidrug resistance protein B - Escherichia coli	5.0E-72	[65..503]	[9..439]
EMRB_HAEIN - Multidrug export protein EmrB OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) ... EMRB_HAEIN - Multidrug resistance protein B homolog OS=Haemophilus influenzae GN=emrB PE=3 SV=1	1.0E-71	[69..502]	[17..442]

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Predicted Domain #1

Region A:
Residues: [1-490]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGNQSLVVLT ESKGEYENET ELPVKKSSRD NNIGESLTAT AFTQSEDEMV DSNQKWQNPN  60
   61 YFKYAWQEYL FIFTCMISQL LNQAGTTQTL SIMNILSDSF GSEGNSKSWL MASFPLVSGS 120
  121 FILISGRLGD IYGLKKMLLV GYVLVIIWSL ICGITKYSGS DTFFIISRAF QGLGIAFVLP 180
  181 NVLGIIGNIY VGGTFRKNIV ISFVGAMAPI GATLGCLFAG LIGTEDPKQW PWAFYAYSIA 240
  241 AFINFVLSIY AIPSTIPTNI HHFSMDWIGS VLGVIGLILL NFVWNQAPIS GWNQAYIIVI 300
  301 LIISVIFLVV FIIYEIRFAK TPLLPRAVIK DRHMIQIMLA LFFGWGSFGI FTFYYFQFQL 360
  361 NIRQYTALWA GGTYFMFLIW GIIAALLVGF TIKNVSPSVF LFFSMVAFNV GSIMASVTPV 420
  421 HETYFRTQLG TMIILSFGMD LSFPASSIIF SDNLPMEYQG MAGSLVNTVV NYSMSLCLGM 480
  481 GATVETQVNS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.39794
Match:	1lviA_
Description:	No description for 1lviA_ was found.

Predicted functions:

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transporter activity	3.3426261924492	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.29689809004391	bayes_pls_golite062009
ion transmembrane transporter activity	1.94035843948137	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
cation transmembrane transporter activity	1.5181741634556	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
binding	1.01584233411372	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [491-542]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGKHLLKGYR GAQYLGIGLA SLACMISGLY MVESFIKGRR ARAAAEYDCT VA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: