YRC Public Data Repository - Protein Structure Prediction

Protein:	YLR456W
Organism:	Saccharomyces cerevisiae
Length:	204 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YLR456W.

Description	E-value	Query Range	Subject Range
YLR456W - Putative protein of unknown function; null mutant displays increased resistance to antifungal agents... YL456_YEAST - Pyridoxamine 5'-phosphate oxidase YLR456W homolog OS=Saccharomyces cerevisiae (strain ATCC 204508 / ...	4.0E-84	[1..204]	[1..204]
SPAC1952.08c - pyridoxamine 5'-phosphate oxidase PDXH_SCHPO - Pyridoxamine 5'-phosphate oxidase C1952.08c homolog OS=Schizosaccharomyces pombe (strain 972 / ATCC ...	1.0E-59	[4..193]	[8..176]
gi\|2598190, gi\|2... - gi\|2598190\|gb\|AAB84003.1\| unknown [Cochliobolus heterostrophus], gi\|2583216\|gb\|AAB82944.1\| unknown [...	4.0E-56	[21..189]	[4..198]
gi\|4928176 - gi\|4928176\|gb\|AAD33446.1\|AF129745_1 unknown [Cochliobolus cymbopogonis]	2.0E-48	[37..189]	[1..175]
gi\|4928179 - gi\|4928179\|gb\|AAD33448.1\|AF129746_1 unknown [Cochliobolus ellisii]	2.0E-46	[61..189]	[1..161]
gi\|4928172 - gi\|4928172\|gb\|AAD33444.1\|AF129743_1 unknown [Cochliobolus kusanoi]	2.0E-46	[65..189]	[1..135]
gi\|4928163 - gi\|4928163\|gb\|AAD33438.1\|AF129740_1 unknown [Cochliobolus luttrellii]	5.0E-46	[61..189]	[1..166]

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Predicted Domain #1

Region A:
Residues: [1-121]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLNEQIPKD LLRLIKSSKY VHVATCSSNC IPSVSLMHYI FVSSAETFHK HEYSIEIDCN  60
   61 DYIIFTVFEK SVTFRNVMSN PNVALLFHDW ITAKNLTLRK KSVHSKDDFS FVESESTKFN 120
  121 N

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [170-204]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILGEDTAIIK VNIQKIKVSD MENNTSTYGQ TVQPV

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.31
Match:	1jnwA
Description:	Pyridoxine 5'-phoshate oxidase (PNP oxidase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pyridoxamine-phosphate oxidase activity	3.19074425223963	bayes_pls_golite062009
catalytic activity	0.636519364005912	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	0.52135782864488	bayes_pls_golite062009
binding	0.495599231495847	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [122-169]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLRDLNQSEL NQVSATINGI ADIVNPNSEE STYYRRLLLT VNPDADIF

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.31
Match:	1jnwA
Description:	Pyridoxine 5'-phoshate oxidase (PNP oxidase)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: