YRC Public Data Repository - Protein Structure Prediction

Protein:	SIR3
Organism:	Saccharomyces cerevisiae
Length:	978 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SIR3.

Description	E-value	Query Range	Subject Range
gi\|4472 - gi\|4472\|emb\|CAA25668.1\| unnamed protein product [Saccharomyces cerevisiae]	0.0	[1..978]	[1..978]
ORC1_CRIGR - Origin recognition complex subunit 1 OS=Cricetulus griseus GN=ORC1 PE=2 SV=1	0.0	[51..940]	[48..848]
ORC1_MOUSE - Origin recognition complex subunit 1 OS=Mus musculus GN=Orc1l PE=2 SV=1	4.0E-96	[201..940]	[131..838]
gi\|1163108 - gi\|1163108\|gb\|AAB38247.1\| origin recognition protein Orc1+p	2.0E-94	[419..972]	[47..540]
ORC1_SCHPO - Origin recognition complex subunit 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=orc1 ... orc1 - origin recognition complex subunit Orc1	2.0E-94	[419..972]	[210..703]
gi\|15079392 - gi\|15079392\|gb\|AAH11539.1\| Origin recognition complex, subunit 1-like (yeast) [Homo sapiens]	3.0E-94	[158..940]	[140..859]
gi\|1621291, gi\|1... - gi\|1621291\|gb\|AAC60033.1\| origin recognition complex protein 1 [Xenopus laevis], gi\|148224764\|ref\|NP...	4.0E-94	[52..940]	[49..884]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	5.0E-94	[158..940]	[140..859]
ORC1_KLULA - Origin recognition complex subunit 1 OS=Kluyveromyces lactis GN=ORC1 PE=3 SV=2 ORC1_KLULA - Origin recognition complex subunit 1 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 7079...	6.0E-89	[271..961]	[197..871]

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Predicted Domain #1

Region A:
Residues: [1-339]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKTLKDLDG WQVIITDDQG RVIDDNNRRR SRKRGGENVF LKRISDGLSF GKGESVIFND  60
   61 NVTETYSVYL IHEIRLNTLN NVVEIWVFSY LRWFELKPKL YYEQFRPDLI KEDHPLEFYK 120
  121 DKFFNEVNKS ELYLTAELSE IWLKDFIAVG QILPESQWND SSIDKIEDRD FLVRYACEPT 180
  181 AEKFVPIDIF QIIRRVKEME PKQSDEYLKR VSVPVSGQKT NRQVMHKMGV ERSSKRLAKK 240
  241 PSMKKIKIEP SADDDVNNGN IPSQRGTSTT HGSISPQEES VSPNISSASP SALTSPTDSS 300
  301 KILQKRSISK ELIVSEEIPI NSSEQESDYE PNNETSVLS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2.522879
Match:	1i84S_
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [340-520]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKPGSKPEKT STELVDGREN FVYANNPEVS DDGGLEEETD EVSSESSDEA IIPVNKRRGA  60
   61 HGSELSSKIR KIHIQETQEF SKNYTTETDN EMNGNGKPGI PRGNTKIHSM NENPTPEKGN 120
  121 AKMIDFATLS KLKKKYQIIL DRFAPDNQVT DSSQLNKLTD EQSSLDVAGL EDKFRKACSS 180
  181 S

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [521-549]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRETILSNFN ADINLEESIR ESLQKRELL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [724-837]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVDKNELQQM IITRLKSLLK PFHVKVNDKK EMTIYNNIRE GQNQKIPDNV IVINHKINNK  60
   61 ITQLIAKNVA NVSGSTEKAF KICEAAVEIS KKDFVRKGGL QKGKLVVSQE MVPR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.154902
Match:	1fnnA_
Description:	CDC6, C-terminal domain; CDC6, N-domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [550-723]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSQVEDFTRI FLPIYDSLMS SQNKLFYITN ADDSTKFQLV NDVMDELITS SARKELPIFD  60
   61 YIHIDALELA GMDALYEKIW FAISKENLCG DISLEALNFY ITNVPKAKKR KTLILIQNPE 120
  121 NLLSEKILQY FEKWISSKNS KLSIICVGGH NVTIREQINI MPSLKAHFTE IKLN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [838-978]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YFSEAINGFK DETISKKIIG MSLLMRTFLY TLAQETEGTN RHTLALETVL IKMVKMLRDN  60
   61 PGYKASKEIK KVICGAWEPA ITIEKLKQFS WISVVNDLVG EKLVVVVLEE PSASIMVELK 120
  121 LPLEINYAFS MDEEFKNMDC I

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.154902
Match:	1fnnA_
Description:	CDC6, C-terminal domain; CDC6, N-domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits