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View Structure Prediction Details

Protein: HRD3
Organism: Saccharomyces cerevisiae
Length: 833 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HRD3.

Description E-value Query
Range
Subject
Range
HRD3 - Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (...
HRD3_YEAST - ERAD-associated E3 ubiquitin-protein ligase component HRD3 OS=Saccharomyces cerevisiae (strain ATCC ...
0.0 [1..833] [1..833]
SEL1L - sel-1 suppressor of lin-12-like (C. elegans)
gi|225000728, gi... - gi|225000928|gb|AAI72577.1| Sel-1 suppressor of lin-12-like (C. elegans) [synthetic construct], gi|2...
2.0E-66 [51..728] [159..768]
SE1L1_MESAU - Protein sel-1 homolog 1 OS=Mesocricetus auratus GN=Sel1l PE=2 SV=1
3.0E-66 [51..728] [159..768]
SE1L1_MOUSE - Protein sel-1 homolog 1 OS=Mus musculus GN=Sel1l PE=1 SV=2
2.0E-65 [51..728] [155..764]
gi|14532716 - gi|14532716|gb|AAK64159.1| unknown protein [Arabidopsis thaliana]
1.0E-56 [139..679] [76..591]
gi|19074843, gi|... - gi|19074843|ref|NP_586349.1| similarity to SKT5 PROTEIN [Encephalitozoon cuniculi GB-M1], gi|1906956...
gi|19074843 - gi|19074843|ref|NP_586349.1| similarity to SKT5 PROTEIN [Encephalitozoon cuniculi GB-M1]
6.0E-51 [154..698] [14..563]

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Predicted Domain #1
Region A:
Residues: [1-169]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITLLLYLCV ICNAIVLIRA DSIADPWPEA RHLLNTIAKS RDPMKEAAME PNADEFVGFY  60
   61 VPMDYSPRNE EKNYQSIWQN EITDSQRHIY ELLVQSSEQF NNSEATYTLS QIHLWSQYNF 120
  121 PHNMTLAHKY LEKFNDLTHF TNHSAIFDLA VMYATGGCAS GNDQTVIPQ

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.79
Match: 1fchA
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [170-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSAKALLYYQ RAAQLGNLKA KQVLAYKYYS GFNVPRNFHK SLVLYRDIAE QLRKSYSRDE  60
   61 WDIVFPYWES Y

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.79
Match: 1fchA
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [241-352]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVRISDFESG LLGKGLNSVP SSTVRKRTTR PDIGSPFIAQ VNGVQMTLQI EPMGRFAFNG  60
   61 NDGNINGDED DEDASERRII RIYYAALNDY KGTYSQSRNC ERAKNLLELT YK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.79
Match: 1fchA
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [353-496]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFQPHVDNLD PLQVFYYVRC LQLLGHMYFT GEGSSKPNIH MAEEILTTSL EISRRAQGPI  60
   61 GRACIDLGLI NQYITNNISQ AISYYMKAMK TQANNGIVEF QLSKLATSFP EEKIGDPFNL 120
  121 METAYLNGFI PAIYEFAVMI ESGM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.39794
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [497-578]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSKSSVENTA YLFKTFVDKN EAIMAPKLRT AFAALINDRS EVALWAYSQL AEQGYETAQV  60
   61 SAAYLMYQLP YEFEDPPRTT DQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.39794
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [579-706]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKTLAISYYT RAFKQGNIDA GVVAGDIYFQ MQNYSKAMAL YQGAALKYSI QAIWNLGYMH  60
   61 EHGLGVNRDF HLAKRYYDQV SEHDHRFYLA SKLSVLKLHL KSWLTWITRE KVNYWKPSSP 120
  121 LNPNEDTQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.39794
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [707-833]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSKTSWYKQL TKILQRMRHK EDSDKAAEDS HKHRTVVQNG ANHRGDDQEE ASEILGFQME  60
   61 DLVTMGCILG IFLLSILMST LAARRGWNVR FNGAQLNANG NRQQEQQQQQ QAQGPPGWDF 120
  121 NVQIFAI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.599 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.598 a.26.1 4-helical cytokines
View Download 0.520 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.593 a.26.1 4-helical cytokines
View Download 0.459 a.118.8 TPR-like
View Download 0.595 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.475 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.578 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.501 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.489 a.118.8 TPR-like
View Download 0.469 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.453 a.118.8 TPR-like
View Download 0.451 c.78.2 Aspartate/glutamate racemase
View Download 0.430 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.429 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.428 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.417 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.415 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.404 a.24.17 Group V grass pollen allergen
View Download 0.402 a.118.11 Cytochrome c oxidase subunit E
View Download 0.384 a.26.1 4-helical cytokines
View Download 0.360 a.182.1 GatB/YqeY domain
View Download 0.356 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.354 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.349 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.348 a.118.8 TPR-like
View Download 0.347 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.342 a.118.8 TPR-like
View Download 0.335 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.333 a.118.8 TPR-like
View Download 0.323 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.322 a.118.8 TPR-like
View Download 0.321 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.320 a.118.8 TPR-like
View Download 0.319 a.118.8 TPR-like
View Download 0.318 a.24.9 alpha-catenin/vinculin
View Download 0.314 a.24.4 Hemerythrin
View Download 0.313 a.26.1 4-helical cytokines
View Download 0.311 a.63.1 Apolipophorin-III
View Download 0.310 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.309 a.118.8 TPR-like
View Download 0.308 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.307 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.306 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.304 a.26.1 4-helical cytokines
View Download 0.298 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.297 a.118.8 TPR-like
View Download 0.296 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.294 a.118.8 TPR-like
View Download 0.293 c.110.1 D-Tyr tRNAtyr deacylase, DTD
View Download 0.287 a.24.4 Hemerythrin
View Download 0.286 a.24.17 Group V grass pollen allergen
View Download 0.286 a.24.17 Group V grass pollen allergen
View Download 0.285 a.24.4 Hemerythrin
View Download 0.282 a.182.1 GatB/YqeY domain
View Download 0.282 a.118.9 ENTH/VHS domain
View Download 0.280 a.26.1 4-helical cytokines
View Download 0.277 a.74.1 Cyclin-like
View Download 0.272 a.23.2 Diol dehydratase, gamma subunit
View Download 0.270 a.118.8 TPR-like
View Download 0.269 a.24.17 Group V grass pollen allergen
View Download 0.267 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.266 c.78.2 Aspartate/glutamate racemase
View Download 0.266 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.265 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.264 a.61.1 Retroviral matrix proteins
View Download 0.262 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.259 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.254 a.26.1 4-helical cytokines
View Download 0.254 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.253 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.253 a.61.1 Retroviral matrix proteins
View Download 0.252 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.251 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.250 a.118.8 TPR-like
View Download 0.248 a.61.1 Retroviral matrix proteins
View Download 0.247 a.61.1 Retroviral matrix proteins
View Download 0.247 a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.247 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.245 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.243 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.242 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.241 a.26.1 4-helical cytokines
View Download 0.241 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.241 a.24.17 Group V grass pollen allergen
View Download 0.240 a.7.1 Spectrin repeat
View Download 0.240 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.238 a.26.1 4-helical cytokines
View Download 0.238 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.235 a.1.1 Globin-like
View Download 0.234 a.118.8 TPR-like
View Download 0.233 a.118.1 ARM repeat
View Download 0.233 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.233 c.78.2 Aspartate/glutamate racemase
View Download 0.231 a.1.2 alpha-helical ferredoxin
View Download 0.231 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.229 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.228 d.146.1 Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
View Download 0.228 a.118.8 TPR-like
View Download 0.228 d.8.1 Urease, gamma-subunit
View Download 0.227 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.226 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.223 d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.222 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.222 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.221 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.221 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.218 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.218 c.78.2 Aspartate/glutamate racemase
View Download 0.217 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.215 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.213 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.213 a.61.1 Retroviral matrix proteins
View Download 0.212 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.212 d.228.1 Replication modulator SeqA, C-terminal DNA-binding domain
View Download 0.212 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.212 a.2.3 Chaperone J-domain
View Download 0.210 a.182.1 GatB/YqeY domain
View Download 0.210 c.78.2 Aspartate/glutamate racemase
View Download 0.210 a.24.17 Group V grass pollen allergen
View Download 0.209 a.7.1 Spectrin repeat
View Download 0.209 a.24.17 Group V grass pollen allergen
View Download 0.208 c.78.2 Aspartate/glutamate racemase
View Download 0.208 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.207 a.2.7 tRNA-binding arm
View Download 0.206 a.118.9 ENTH/VHS domain
View Download 0.205 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.202 a.45.1 Glutathione S-transferase (GST), C-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle