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View Structure Prediction Details

Protein: UBP11
Organism: Saccharomyces cerevisiae
Length: 717 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBP11.

Description E-value Query
Range
Subject
Range
UBP11_YEAST - Ubiquitin carboxyl-terminal hydrolase 11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
UBP11 - Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
0.0 [1..717] [1..717]
gi|2655204 - gi|2655204|gb|AAC53587.1| ubiquitin-specific protease [Mus musculus]
5.0E-79 [92..491] [83..490]
gi|16552833, gi|... - gi|21361712|ref|NP_004196.3| ubiquitin specific peptidase 2 isoform a [Homo sapiens], gi|16552833|db...
9.0E-79 [121..705] [107..597]
gi|3800764 - gi|3800764|gb|AAC68865.1| ubiquitin specific protease 66 [Gallus gallus]
3.0E-78 [290..705] [38..376]
gi|6492126, gi|5... - gi|6492126|gb|AAF14190.1|AF106659_1 deubiquitinating enzyme Ubp69 [Rattus norvegicus], gi|51592088|r...
2.0E-76 [121..705] [107..610]

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Predicted Domain #1
Region A:
Residues: [1-54]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLNPDQILN LVRKVYEVDI KQFYSQLRLK NLRGLLDHAA HLFNVYLRDL EINQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.624 0.029 ubiquitin-specific protease activity a.4.1 Homeodomain-like
View Download 0.544 0.029 ubiquitin-specific protease activity a.5.2 UBA-like
View Download 0.461 0.029 ubiquitin-specific protease activity a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.839 0.029 ubiquitin-specific protease activity a.144.1 PABC (PABP) domain
View Download 0.724 0.029 ubiquitin-specific protease activity a.144.2 Ribosomal protein L20
View Download 0.435 0.029 ubiquitin-specific protease activity a.5.2 UBA-like
View Download 0.403 0.029 ubiquitin-specific protease activity a.4.1 Homeodomain-like
View Download 0.402 0.029 ubiquitin-specific protease activity a.4.1 Homeodomain-like
View Download 0.397 0.029 ubiquitin-specific protease activity a.4.1 Homeodomain-like
View Download 0.382 0.029 ubiquitin-specific protease activity a.65.1 Annexin
View Download 0.374 0.029 ubiquitin-specific protease activity a.4.1 Homeodomain-like
View Download 0.349 0.029 ubiquitin-specific protease activity a.2.9 C-terminal UvrC-binding domain of UvrB
View Download 0.335 0.029 ubiquitin-specific protease activity a.4.1 Homeodomain-like
View Download 0.334 0.029 ubiquitin-specific protease activity a.35.1 lambda repressor-like DNA-binding domains
View Download 0.324 0.029 ubiquitin-specific protease activity f.13.1 Family A G protein-coupled receptor-like
View Download 0.313 0.029 ubiquitin-specific protease activity g.1.1 Insulin-like
View Download 0.306 0.029 ubiquitin-specific protease activity a.5.2 UBA-like
View Download 0.306 0.029 ubiquitin-specific protease activity a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.305 0.029 ubiquitin-specific protease activity a.5.2 UBA-like
View Download 0.302 0.029 ubiquitin-specific protease activity a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.292 0.029 ubiquitin-specific protease activity a.60.11 Hypothetical protein YjbJ
View Download 0.291 0.029 ubiquitin-specific protease activity a.4.5 "Winged helix" DNA-binding domain
View Download 0.287 0.029 ubiquitin-specific protease activity a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.283 0.029 ubiquitin-specific protease activity a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.268 0.029 ubiquitin-specific protease activity a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.266 0.029 ubiquitin-specific protease activity a.2.2 Ribosomal protein L29 (L29p)
View Download 0.266 0.029 ubiquitin-specific protease activity a.4.5 "Winged helix" DNA-binding domain
View Download 0.264 0.029 ubiquitin-specific protease activity a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.259 0.029 ubiquitin-specific protease activity a.4.8 Ribosomal protein S18
View Download 0.256 0.029 ubiquitin-specific protease activity a.4.5 "Winged helix" DNA-binding domain
View Download 0.248 0.029 ubiquitin-specific protease activity a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.230 0.029 ubiquitin-specific protease activity a.112.1 Description not found.
View Download 0.227 0.029 ubiquitin-specific protease activity a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.225 0.029 ubiquitin-specific protease activity a.4.11 RNA polymerase subunit RPB10
View Download 0.221 0.029 ubiquitin-specific protease activity a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.216 0.029 ubiquitin-specific protease activity a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.215 0.029 ubiquitin-specific protease activity a.77.1 DEATH domain
View Download 0.213 0.029 ubiquitin-specific protease activity d.186.1 Head-to-tail joining protein W, gpW
View Download 0.211 0.029 ubiquitin-specific protease activity a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.203 0.029 ubiquitin-specific protease activity a.4.5 "Winged helix" DNA-binding domain

Predicted Domain #2
Region A:
Residues: [55-246]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EMEALTAFII GCYYLYLIIP QSLQFQTRNN LYSSYAKLKN DYQDEHVMGY VLKVVRDEST  60
   61 VIVDRYLAES NGICRTIKRK RAYSLPLRPL PVHMASLSIH NKFDGSLHEI PNELTKPTND 120
  121 NSKEDIVRES NQIASSNKLE AGSEVAYYTS KEALSKPSYL KLSTGKDALF KTLSSPATAP 180
  181 PVHSLEVSSQ IR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [247-382]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSSQDSSSSL SKVEKPKEEE GKIEAIESSA PKAYNLPVIE DSNDLLSELS ITGLQNPCNT  60
   61 CYINSIIQCL FGTTLFRDLF LTKKYRLFLN TNKYPKEVQL SRSIYVLFKK MYLNGGRAII 120
  121 PNRFLKMCKK LRPDLN

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 13.327902
Match: PF00442
Description: No description for PF00442 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [383-522]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPDDQQDTQE FLLIVLARIH EELSNENVVK YYPDLVSYDA NALQVNPSKY EKWYERNVIT  60
   61 DGLSPIDHIY RGQLENILKC QRCGNSSYSY STFYVLSLAI PKLSLYSFTS KSRKIKLEDC 120
  121 INLFTGDEEL SGDNAWDCPN 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.396 0.218 ubiquitin-specific protease activity a.26.1 4-helical cytokines
View Download 0.355 0.041 ubiquitin-specific protease activity d.110.1 Profilin (actin-binding protein)
View Download 0.501 0.038 ubiquitin-specific protease activity a.39.2 Insect pheromon/odorant-binding proteins
View Download 0.358 0.023 ubiquitin-specific protease activity c.23.13 Type II 3-dehydroquinate dehydratase
View Download 0.411 0.016 ubiquitin-specific protease activity c.121.1 Ribose/Galactose isomerase RpiB/AlsB
View Download 0.332 N/A N/A a.182.1 GatB/YqeY domain
View Download 0.331 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.316 N/A N/A i.11.1 Computational models partly based on NMR data
View Download 0.315 N/A N/A c.62.1 vWA-like
View Download 0.299 N/A N/A c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.258 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.234 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.230 N/A N/A d.218.1 Nucleotidyltransferase
View Download 0.225 N/A N/A c.78.2 Aspartate/glutamate racemase
View Download 0.218 N/A N/A a.11.2 Second domain of FERM
View Download 0.214 N/A N/A a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.207 N/A N/A d.13.1 HIT-like

Predicted Domain #5
Region A:
Residues: [523-622]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CRITDSKSKK EEITSQKKKS TIFGFHSRSR SKSPHHHHHH HHSSDDSTKN AKKRNSKKLT  60
   61 TIKSLDFIVL PPILVIHLSR FYYDLTKKNS TVITYPLILN 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.447 a.1.1 Globin-like
View Download 0.436 a.118.1 ARM repeat
View Download 0.410 d.109.1 Actin depolymerizing proteins
View Download 0.383 a.74.1 Cyclin-like
View Download 0.396 a.24.17 Group V grass pollen allergen
View Download 0.365 d.192.1 YlxR-like
View Download 0.364 d.58.9 RuBisCO, large subunit, small (N-terminal) domain
View Download 0.351 b.71.1 Glycosyl hydrolase domain
View Download 0.347 c.103.1 Hypothetical protein MT938 (MTH938)
View Download 0.313 d.52.4 YhbC-like, N-terminal domain
View Download 0.300 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.297 d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.287 c.95.1 Thiolase-like
View Download 0.282 d.52.5 Probable GTPase Der, C-terminal domain
View Download 0.278 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.267 d.52.6 BolA-like
View Download 0.264 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.263 d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.254 c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.241 d.58.17 Metal-binding domain
View Download 0.230 d.58.45 PurS subunit of FGAM synthetase
View Download 0.225 a.4.1 Homeodomain-like
View Download 0.216 d.58.47 Hypothetical protein VC0424
View Download 0.215 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.214 a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.209 d.80.1 Tautomerase/MIF
View Download 0.209 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.208 d.80.1 Tautomerase/MIF

Predicted Domain #6
Region A:
Residues: [623-717]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IILKNGKVIR YKLYGTVNHS GNLINGHYTS VVNKEKSHEI GLNRQVWVTF DDDYIQQHRK  60
   61 DRNNFEAGKT EMSSDEVYVL FYERMDEENY EEEFC

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 23.070581
Match: PF00443
Description: Ubiquitin carboxyl-terminal hydrolase

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle