YRC Public Data Repository - Protein Structure Prediction

Protein:	IRS4
Organism:	Saccharomyces cerevisiae
Length:	615 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IRS4.

Description	E-value	Query Range	Subject Range
IRS4_YEAST - Increased rDNA silencing protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IRS4 ... IRS4 - EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and...	0.0	[1..615]	[1..615]
gi\|110742187, gi... - gi\|8886934\|gb\|AAF80620.1\|AC069251_13 F2D10.25 [Arabidopsis thaliana], gi\|15218021\|ref\|NP_173499.1\| c...	4.0E-45	[281..565]	[190..442]
gi\|18203725, gi\|... - gi\|57208696\|emb\|CAI42878.1\| RALBP1 associated Eps domain containing 1 [Homo sapiens], gi\|18203725\|gb...	8.0E-43	[283..581]	[45..335]
REPS1_MOUSE, REP... - RalBP1-associated Eps domain-containing protein 1 OS=Mus musculus GN=Reps1 PE=1 SV=1, (O54916) RalBP...	2.0E-42	[283..576]	[45..327]
rme-1 - status:Confirmed UniProt:Q966F0 protein_id:AAK73902.2	8.0E-41	[443..579]	[427..570]
Past1-PB - The gene Putative Achaete Scute Target 1 is referred to in FlyBase by the symbol Dmel\Past1 (CG6148,...	9.0E-38	[444..571]	[403..533]

Back

Predicted Domain #1

Region A:
Residues: [1-474]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLSFGKQRY HGGTTVTLTE QGASDSLRAA QAIFQNHSNE VSSPCPPVTV SRNPQTRLSE  60
   61 PSLQKSGRKQ EQKKARIRTK QVPKIKTTAP NDVELSKKHR SSPAGKDNVS STAQMAAALA 120
  121 HSQSKLSSDN NSSHSSALDT LKVLETPNLN GLLGIHSRSS SRNGSNESLT PGQRTPDNRS 180
  181 QENLLTSFSS GRRLSSSSME PATNKDSNKA LPKRRPSPPL QSSLVGSGQL HENENLSSIS 240
  241 IDSRHSLNPD TSDVISNRSQ TSLSQTINQL SLCESEPSIA SSNTTTTTSN QGSGLPNLVP 300
  301 NYSSDMRKKK LVNKFKRKVF GSKPKHLSSQ YEMDASSEEL GQHEQQPSMR FKTTLRKTSV 360
  361 STNAENDHAS SLHEGNLRYK YNPSNDTYDV YDDTDSDSES DQNQDALTKP RKRDRIKRKI 420
  421 RNSANKTAHH RPIHRTRDRK FNEDKPWKSH TDITFVTDNE RKRYESMWVS NRHR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [475-615]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HLNLLSWWPS ITGDSGAINT LPEDGLILGI IVRDIWKRSN LPNSLLAEIY TKVDTRKDGT  60
   61 LDRKSFIVGM WLVDQCLYGR KLPNVVEQCV WDSVDRYAST TVVPVSTLKA MAKQKRKQMK 120
  121 EEIKNIKKEN RVVLVDHNSS S

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.36704
Match:	1c07A_
Description:	Eps15
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [446-615]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PWKSHTDITF VTDNERKRYE SMWVSNRHRH LNLLSWWPSI TGDSGAINTL PEDGLILGII  60
   61 VRDIWKRSNL PNSLLAEIYT KVDTRKDGTL DRKSFIVGMW LVDQCLYGRK LPNVVEQCVW 120
  121 DSVDRYASTT VVPVSTLKAM AKQKRKQMKE EIKNIKKENR VVLVDHNSSS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.045757
Match:	2qptA
Description:	No description for 2qptA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits