YRC Public Data Repository - Protein Structure Prediction

Protein:	GPM1
Organism:	Saccharomyces cerevisiae
Length:	247 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GPM1.

Description	E-value	Query Range	Subject Range
gi\|7437400 - gi\|7437400\|pir\|\|A70182 phosphoglycerate mutase (gpmA) homolog - Lyme disease spirochete gi\|2688589, gi\|1... - gi\|2688589\|gb\|AAC67007.1\| phosphoglycerate mutase (gpmA) [Borrelia burgdorferi B31], gi\|15595003\|ref...	1.0E-79	[1..246]	[6..251]
PGAM2_MOUSE - Phosphoglycerate mutase 2 OS=Mus musculus GN=Pgam2 PE=1 SV=3	1.0E-78	[3..246]	[5..251]
PGAM2_RAT - Phosphoglycerate mutase 2 OS=Rattus norvegicus GN=Pgam2 PE=1 SV=2	3.0E-78	[3..246]	[5..251]
gi\|166159344, gi... - gi\|16904828\|gb\|AAL30898.1\| phosphoglycerate mutase [Schistosoma japonicum], gi\|166159344\|gb\|ABY83139...	4.0E-78	[3..247]	[5..249]
gi\|387016 - gi\|387016\|gb\|AAA60073.1\| phosphoglycerate mutase [Homo sapiens]	6.0E-78	[3..246]	[5..251]
gi\|17427362 - gi\|17427362\|emb\|CAD13881.1\| probable 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (phos... gi\|17545072 - gi\|17545072\|ref\|NP_518474.1\| phosphoglyceromutase [Ralstonia solanacearum GMI1000]	6.0E-78	[1..246]	[20..265]
GPM1 - Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycer... PMG1_YEAST - Phosphoglycerate mutase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GPM1 PE=1 SV=3 gi\|151941656 - gi\|151941656\|gb\|EDN60018.1\| phosphoglycerate mutase [Saccharomyces cerevisiae YJM789] gi\|190409687 - gi\|190409687\|gb\|EDV12952.1\| phosphoglycerate mutase [Saccharomyces cerevisiae RM11-1a]	2.0E-77	[1..247]	[1..247]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-77	[3..246]	[5..251]
gi\|8248819 - gi\|8248819\|gb\|AAB19888.2\| phosphoglycerate mutase type B subunit [Rattus sp.]	5.0E-77	[3..246]	[5..251]

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Predicted Domain #1

Region A:
Residues: [1-247]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKLVLVRHG QSEWNEKNLF TGWVDVKLSA KGQQEAARAG ELLKEKKVYP DVLYTSKLSR  60
   61 AIQTANIALE KADRLWIPVN RSWRLNERHY GDLQGKDKAE TLKKFGEEKF NTYRRSFDVP 120
  121 PPPIDASSPF SQKGDERYKY VDPNVLPETE SLALVIDRLL PYWQDVIAKD LLSGKTVMIA 180
  181 AHGNSLRGLV KHLEGISDAD IAKLNIPTGI PLVFELDENL KPSKPSYYLD PEAAAAGAAA 240
  241 VANQGKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1387.09691
Match:	1bq3D_
Description:	Phosphoglycerate mutase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoglycerate mutase activity	3.38777226675734	bayes_pls_golite062009
phosphofructokinase activity	3.23286891159765	bayes_pls_golite062009
fructose-2,6-bisphosphate 2-phosphatase activity	2.79017097989614	bayes_pls_golite062009
6-phosphofructo-2-kinase activity	2.66778782568695	bayes_pls_golite062009
acid phosphatase activity	2.30852687504184	bayes_pls_golite062009
hydrolase activity	2.03142958239384	bayes_pls_golite062009
carbohydrate kinase activity	1.86382423322759	bayes_pls_golite062009
carbohydrate phosphatase activity	1.56016941506609	bayes_pls_golite062009
binding	1.50412762608586	bayes_pls_golite062009
catalytic activity	1.37714494241232	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.05740895199147	bayes_pls_golite062009
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity	1.02570448989802	bayes_pls_golite062009
phosphatase activity	0.977262057801137	bayes_pls_golite062009
intramolecular transferase activity, phosphotransferases	0.916759493094631	bayes_pls_golite062009
phosphoric ester hydrolase activity	0.780670874345357	bayes_pls_golite062009
isomerase activity	0.275500708652009	bayes_pls_golite062009
protein binding	0.236742803345453	bayes_pls_golite062009
intramolecular transferase activity	0.22072573159348	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.116796724149401	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: