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View Structure Prediction Details

Protein: MIF2
Organism: Saccharomyces cerevisiae
Length: 549 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MIF2.

Description E-value Query
Range
Subject
Range
MIF2 - Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle ...
MIF2_YEAST - Protein MIF2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MIF2 PE=1 SV=1
gi|151941714 - gi|151941714|gb|EDN60076.1| mitotic fidelity of chromosome transmission-related protein [Saccharomyc...
0.0 [1..549] [1..549]
CENPC_MOUSE, CEN... - Centromere protein C 1 OS=Mus musculus GN=Cenpc1 PE=1 SV=1, (P49452) Centromere protein C (CENP-C) (...
6.0E-88 [19..528] [397..905]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
6.0E-88 [19..528] [397..905]
CENPC_SHEEP - Centromere protein C (Fragment) OS=Ovis aries GN=CENPC PE=2 SV=1
8.0E-83 [94..528] [2..401]
gi|2749775 - gi|2749775|dbj|BAA24110.1| CENP-C [Gallus gallus]
8.0E-67 [77..528] [409..837]
gi|1176458 - gi|1176458|gb|AAB35518.1| CENP-C=centromeric protein {C-terminal} [mice, Peptide Partial, 245 aa]
1.0E-65 [259..528] [1..244]
ZAN - zonadhesin
1.0E-64 [29..402] [471..905]

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Predicted Domain #1
Region A:
Residues: [1-7]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYMKLG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [231-314]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSGSDSASDS DGDNTYQEVE EEAEVNTNDN EDDYIRRQAS DVVRTDSIID RNGLRKSTRV  60
   61 KVAPLQYWRN EKIVYKRKSN KPVL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.54
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #2
Region A:
Residues: [8-81]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKSRKTGIDV KQDIPKDEYS MENIDDFFKD DETSLISMRR KSRRKSSLFL PSTLNGDTKN  60
   61 VLPPFLQSYK SQDD

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.54
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #3
Region A:
Residues: [82-160]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVVQSPSGKG DGSRRSSLLS HQSNFLSPAN DFEPIEEEPE QEENDIRGND FATPITQKLS  60
   61 KPTYKRKYST RYSLDTSES

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.54
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #4
Region A:
Residues: [161-230]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSVRLTPDRI TNKNVYSDVP DLVADEDDDD RVNTSLNTSD NALLEDELED DGFIPESEED  60
   61 GDYIESDSSL 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.54
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted functions:

Term Confidence Notes
binding 1.44422021392403 bayes_pls_golite062009
protein binding 0.3553694547469 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [315-470]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DIDKIVTYDE SEDEEEILAA QRRKKQKKKP TPTRPYNYVP TGRPRGRPKK DPNAKENLIP  60
   61 EDPNEDIIER IESGGIENGE WLKHGILEAN VKISDTKEET KDEIIAFAPN LSQTEQVKDT 120
  121 KDENFALEIM FDKHKEYFAS GILKLPAISG QKKLSN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [471-549]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFRTYITFHV IQGIVEVTVC KNKFLSVKGS TFQIPAFNEY AIANRGNDEA KMFFVQVTVS  60
   61 EDANDDNDKE LDSTFDTFG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.420 0.266 mitotic spindle organization in nucleus b.55.1 PH domain-like
View Download 0.379 0.048 mitotic spindle organization in nucleus b.84.2 Rudiment single hybrid motif
View Download 0.548 0.023 mitotic spindle organization in nucleus d.58.12 eEF-1beta-like
View Download 0.497 0.007 mitotic spindle organization in nucleus d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.507 N/A N/A d.175.1 Penicillin binding protein dimerisation domain
View Download 0.355 N/A N/A d.58.12 eEF-1beta-like
View Download 0.354 N/A N/A a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.318 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.296 N/A N/A b.1.2 Fibronectin type III
View Download 0.295 N/A N/A d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.293 N/A N/A d.170.2 A heparin-binding domain
View Download 0.288 N/A N/A b.24.1 Hyaluronate lyase-like, C-terminal domain
View Download 0.277 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.274 N/A N/A d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.270 N/A N/A d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.254 N/A N/A d.15.4 2Fe-2S ferredoxin-like
View Download 0.242 N/A N/A d.58.4 Dimeric alpha+beta barrel
View Download 0.236 N/A N/A d.129.2 Phosphoglucomutase, C-terminal domain
View Download 0.236 N/A N/A b.55.1 PH domain-like
View Download 0.231 N/A N/A b.1.1 Immunoglobulin
View Download 0.225 N/A N/A b.1.1 Immunoglobulin
View Download 0.222 N/A N/A b.1.1 Immunoglobulin
View Download 0.222 N/A N/A d.58.48 MTH1187-like
View Download 0.217 N/A N/A b.40.6 MOP-like
View Download 0.208 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle