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View Structure Prediction Details

Protein: NUP120
Organism: Saccharomyces cerevisiae
Length: 1037 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NUP120.

Description E-value Query
Range
Subject
Range
NUP120 - Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for even distribution o...
NU120_YEAST - Nucleoporin NUP120 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NUP120 PE=1 SV=1
0.0 [1..1037] [1..1037]

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Predicted Domain #1
Region A:
Residues: [1-479]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MACLSRIDAN LLQYYEKPEP NNTVDLYVSN NSNNNGLKEG DKSISTPVPQ PYGSEYSNCL  60
   61 LLSNSEYICY HFSSRSTLLT FYPLSDAYHG KTINIHLPNA SMNQRYTLTI QEVEQQLLVN 120
  121 VILKDGSFLT LQLPLSFLFS SANTLNGEWF HLQNPYDFTV RVPHFLFYVS PQFSVVFLED 180
  181 GGLLGLKKVD GVHYEPLLFN DNSYLKSLTR FFSRSSKSDY DSVISCKLFH ERYLIVLTQN 240
  241 CHLKIWDLTS FTLIQDYDMV SQSDSDPSHF RKVEAVGEYL SLYNNTLVTL LPLENGLFQM 300
  301 GTLLVDSSGI LTYTFQNNIP TNLSASAIWS IVDLVLTRPL ELNVEASYLN LIVLWKSGTA 360
  361 SKLQILNVND ESFKNYEWIE SVNKSLVDLQ SEHDLDIVTK TGDVERGFCN LKSRYGTQIF 420
  421 ERAQQILSEN KIIMAHNEDE EYLANLETIL RDVKTAFNEA SSITLYGDEI ILVNCFQPY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
nucleocytoplasmic transporter activity 6.69510224853745 bayes_pls_golite062009
transporter activity 2.44173429092591 bayes_pls_golite062009
binding 1.85742618935461 bayes_pls_golite062009
structural molecule activity 1.08319592328349 bayes_pls_golite062009
protein binding 0.749555781220334 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [480-1037]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NHSLYKLNTT VENWFYNMHS ETDGSELFKY LRTLNGFAST LSNDVLRSIS KKFLDIITGE  60
   61 LPDSMTTVEK FTDIFKNCLE NQFEITNLKI LFDELNSFDI PVVLNDLINN QMKPGIFWKK 120
  121 DFISAIKFDG FTSIISLESL HQLLSIHYRI TLQVLLTFVL FDLDTEIFGQ HISTLLDLHY 180
  181 KQFLLLNLYR QDKCLLAEVL LKDSSEFSFG VKFFNYGQLI AYIDSLNSNV YNASITENSF 240
  241 FMTFFRSYII ENTSHKNIRF FLENVECPFY LRHNEVQEFM FAMTLFSCGN FDQSYEIFQL 300
  301 HDYPEAINDK LPTFLEDLKS ENYHGDSIWK DLLCTFTVPY RHSAFYYQLS LLFDRNNSQE 360
  361 FALKCISKSA EYSLKEIQIE ELQDFKEKQH IHYLNLLIHF RMFEEVLDVL RLGHECLSDT 420
  421 VRTNFLQLLL QEDIYSRDFF STLLRLCNAH SDNGELYLRT VDIKIVDSIL SQNLRSGDWE 480
  481 CFKKLYCFRM LNKSERAAAE VLYQYILMQA DLDVIRKRKC YLMVINVLSS FDSAYDQWIL 540
  541 NGSKVVTLTD LRDELRGL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [590-745]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QMKPGIFWKK DFISAIKFDG FTSIISLESL HQLLSIHYRI TLQVLLTFVL FDLDTEIFGQ  60
   61 HISTLLDLHY KQFLLLNLYR QDKCLLAEVL LKDSSEFSFG VKFFNYGQLI AYIDSLNSNV 120
  121 YNASITENSF FMTFFRSYII ENTSHKNIRF FLENVE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [746-1037]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPFYLRHNEV QEFMFAMTLF SCGNFDQSYE IFQLHDYPEA INDKLPTFLE DLKSENYHGD  60
   61 SIWKDLLCTF TVPYRHSAFY YQLSLLFDRN NSQEFALKCI SKSAEYSLKE IQIEELQDFK 120
  121 EKQHIHYLNL LIHFRMFEEV LDVLRLGHEC LSDTVRTNFL QLLLQEDIYS RDFFSTLLRL 180
  181 CNAHSDNGEL YLRTVDIKIV DSILSQNLRS GDWECFKKLY CFRMLNKSER AAAEVLYQYI 240
  241 LMQADLDVIR KRKCYLMVIN VLSSFDSAYD QWILNGSKVV TLTDLRDELR GL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.975
Match: 1qqeA
Description: Vesicular transport protein sec17
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.50062202757362 bayes_pls_golite062009
protein binding 1.72061787550863 bayes_pls_golite062009
signal sequence binding 1.06643404565266 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle