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View Structure Prediction Details

Protein: ASK1
Organism: Saccharomyces cerevisiae
Length: 292 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ASK1.

Description E-value Query
Range
Subject
Range
ASK1 - Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced...
0.0 [1..292] [1..292]
ASK1_SCHPO - DASH complex subunit ask1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ask1 PE=1 SV=1
ask1 - DASH complex subunit Ask1
2.0E-67 [8..173] [5..165]
gi|1236275 - gi|1236275|dbj|BAA12199.1| unnamed protein product [Schizosaccharomyces pombe]
9.0E-27 [98..173] [2..78]

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Predicted Domain #1
Region A:
Residues: [1-96]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSASKEETL EKLVQEITVN LQKIDSNLSF CFHKITQDII PHVATYSEIC ERIMDSTEWL  60
   61 GTMFQETGLV NLQANAAAPV GNAPVKSLVS NNVGIF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.822 0.041 mitotic spindle organization in nucleus a.60.9 lambda integrase-like, N-terminal domain
View Download 0.570 0.041 mitotic spindle organization in nucleus f.15.1 Small-conductance potassium channel
View Download 0.662 0.041 mitotic spindle organization in nucleus f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.589 0.041 mitotic spindle organization in nucleus a.5.4 Elongation factor TFIIS domain 2
View Download 0.822 0.041 mitotic spindle organization in nucleus a.60.9 lambda integrase-like, N-terminal domain
View Download 0.662 0.041 mitotic spindle organization in nucleus f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.589 0.041 mitotic spindle organization in nucleus a.5.4 Elongation factor TFIIS domain 2
View Download 0.570 0.041 mitotic spindle organization in nucleus f.15.1 Small-conductance potassium channel
View Download 0.567 0.041 mitotic spindle organization in nucleus a.5.4 Elongation factor TFIIS domain 2
View Download 0.567 0.041 mitotic spindle organization in nucleus a.5.4 Elongation factor TFIIS domain 2
View Download 0.567 0.041 mitotic spindle organization in nucleus a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.563 0.041 mitotic spindle organization in nucleus a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.547 0.041 mitotic spindle organization in nucleus c.78.2 Aspartate/glutamate racemase
View Download 0.544 0.041 mitotic spindle organization in nucleus a.24.17 Group V grass pollen allergen
View Download 0.502 0.041 mitotic spindle organization in nucleus a.24.9 alpha-catenin/vinculin
View Download 0.496 0.041 mitotic spindle organization in nucleus i.11.1 Computational models partly based on NMR data
View Download 0.493 0.041 mitotic spindle organization in nucleus a.60.9 lambda integrase-like, N-terminal domain
View Download 0.492 0.041 mitotic spindle organization in nucleus a.5.4 Elongation factor TFIIS domain 2
View Download 0.485 0.041 mitotic spindle organization in nucleus i.1.1 Ribosome and ribosomal fragments
View Download 0.484 0.041 mitotic spindle organization in nucleus a.24.9 alpha-catenin/vinculin
View Download 0.477 0.041 mitotic spindle organization in nucleus a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.477 0.041 mitotic spindle organization in nucleus a.24.4 Hemerythrin
View Download 0.476 0.041 mitotic spindle organization in nucleus a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.469 0.041 mitotic spindle organization in nucleus a.7.7 BAG domain
View Download 0.466 0.041 mitotic spindle organization in nucleus a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.462 0.041 mitotic spindle organization in nucleus a.61.1 Retroviral matrix proteins
View Download 0.457 0.041 mitotic spindle organization in nucleus a.24.4 Hemerythrin
View Download 0.452 0.041 mitotic spindle organization in nucleus a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.432 0.041 mitotic spindle organization in nucleus a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.404 0.041 mitotic spindle organization in nucleus a.24.17 Group V grass pollen allergen
View Download 0.399 0.041 mitotic spindle organization in nucleus a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.397 0.041 mitotic spindle organization in nucleus a.5.4 Elongation factor TFIIS domain 2
View Download 0.390 0.041 mitotic spindle organization in nucleus d.82.2 Frataxin-like
View Download 0.369 0.041 mitotic spindle organization in nucleus a.24.3 Cytochromes
View Download 0.365 0.041 mitotic spindle organization in nucleus a.7.5 Tubulin chaperone cofactor A
View Download 0.365 0.041 mitotic spindle organization in nucleus a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.363 0.041 mitotic spindle organization in nucleus a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.353 0.041 mitotic spindle organization in nucleus a.24.17 Group V grass pollen allergen
View Download 0.352 0.041 mitotic spindle organization in nucleus a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.351 0.041 mitotic spindle organization in nucleus a.24.9 alpha-catenin/vinculin
View Download 0.349 0.041 mitotic spindle organization in nucleus a.24.17 Group V grass pollen allergen
View Download 0.347 0.041 mitotic spindle organization in nucleus a.24.17 Group V grass pollen allergen
View Download 0.344 0.041 mitotic spindle organization in nucleus c.12.1 Ribosomal proteins L15p and L18e
View Download 0.344 0.041 mitotic spindle organization in nucleus a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.343 0.041 mitotic spindle organization in nucleus a.74.1 Cyclin-like
View Download 0.341 0.041 mitotic spindle organization in nucleus a.1.1 Globin-like
View Download 0.338 0.041 mitotic spindle organization in nucleus a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.336 0.041 mitotic spindle organization in nucleus c.23.1 CheY-like
View Download 0.335 0.041 mitotic spindle organization in nucleus a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.335 0.041 mitotic spindle organization in nucleus a.1.1 Globin-like
View Download 0.335 0.041 mitotic spindle organization in nucleus a.7.6 Ribosomal protein S20
View Download 0.326 0.041 mitotic spindle organization in nucleus a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.326 0.041 mitotic spindle organization in nucleus a.4.1 Homeodomain-like
View Download 0.325 0.041 mitotic spindle organization in nucleus a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.322 0.041 mitotic spindle organization in nucleus a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.321 0.041 mitotic spindle organization in nucleus d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.318 0.041 mitotic spindle organization in nucleus a.90.1 Transcription factor STAT-4 N-domain
View Download 0.317 0.041 mitotic spindle organization in nucleus a.112.1 Description not found.
View Download 0.315 0.041 mitotic spindle organization in nucleus a.59.1 PAH2 domain
View Download 0.313 0.041 mitotic spindle organization in nucleus a.24.17 Group V grass pollen allergen
View Download 0.311 0.041 mitotic spindle organization in nucleus a.46.1 Methionine synthase domain
View Download 0.309 0.041 mitotic spindle organization in nucleus a.1.1 Globin-like
View Download 0.308 0.041 mitotic spindle organization in nucleus f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.304 0.041 mitotic spindle organization in nucleus a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.299 0.041 mitotic spindle organization in nucleus a.60.8 HRDC-like
View Download 0.295 0.041 mitotic spindle organization in nucleus a.47.2 t-snare proteins
View Download 0.292 0.041 mitotic spindle organization in nucleus a.60.9 lambda integrase-like, N-terminal domain
View Download 0.289 0.041 mitotic spindle organization in nucleus a.83.1 Guanido kinase N-terminal domain
View Download 0.287 0.041 mitotic spindle organization in nucleus a.24.17 Group V grass pollen allergen
View Download 0.286 0.041 mitotic spindle organization in nucleus a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.284 0.041 mitotic spindle organization in nucleus a.60.9 lambda integrase-like, N-terminal domain
View Download 0.281 0.041 mitotic spindle organization in nucleus a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.281 0.041 mitotic spindle organization in nucleus a.1.1 Globin-like
View Download 0.281 0.041 mitotic spindle organization in nucleus a.24.17 Group V grass pollen allergen
View Download 0.281 0.041 mitotic spindle organization in nucleus d.141.1 Ribosomal protein L6
View Download 0.277 0.041 mitotic spindle organization in nucleus a.60.9 lambda integrase-like, N-terminal domain
View Download 0.274 0.041 mitotic spindle organization in nucleus d.58.48 MTH1187-like
View Download 0.271 0.041 mitotic spindle organization in nucleus a.24.11 Bacterial GAP domain
View Download 0.265 0.041 mitotic spindle organization in nucleus a.60.9 lambda integrase-like, N-terminal domain
View Download 0.262 0.041 mitotic spindle organization in nucleus d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.261 0.041 mitotic spindle organization in nucleus a.72.1 Functional domain of the splicing factor Prp18
View Download 0.260 0.041 mitotic spindle organization in nucleus a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.260 0.041 mitotic spindle organization in nucleus a.24.1 Apolipoprotein
View Download 0.255 0.041 mitotic spindle organization in nucleus f.17.1 F1F0 ATP synthase subunit C
View Download 0.251 0.041 mitotic spindle organization in nucleus a.60.9 lambda integrase-like, N-terminal domain
View Download 0.251 0.041 mitotic spindle organization in nucleus a.24.1 Apolipoprotein
View Download 0.250 0.041 mitotic spindle organization in nucleus a.133.1 Phospholipase A2, PLA2
View Download 0.250 0.041 mitotic spindle organization in nucleus d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.250 0.041 mitotic spindle organization in nucleus a.74.1 Cyclin-like
View Download 0.244 0.041 mitotic spindle organization in nucleus f.17.1 F1F0 ATP synthase subunit C
View Download 0.243 0.041 mitotic spindle organization in nucleus c.30.1 PreATP-grasp domain
View Download 0.238 0.041 mitotic spindle organization in nucleus a.16.1 S15/NS1 RNA-binding domain
View Download 0.234 0.041 mitotic spindle organization in nucleus f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.233 0.041 mitotic spindle organization in nucleus d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.232 0.041 mitotic spindle organization in nucleus a.74.1 Cyclin-like
View Download 0.232 0.041 mitotic spindle organization in nucleus c.47.1 Thioredoxin-like
View Download 0.232 0.041 mitotic spindle organization in nucleus a.77.1 DEATH domain
View Download 0.231 0.041 mitotic spindle organization in nucleus f.17.1 F1F0 ATP synthase subunit C
View Download 0.230 0.041 mitotic spindle organization in nucleus d.110.1 Profilin (actin-binding protein)
View Download 0.228 0.041 mitotic spindle organization in nucleus a.133.1 Phospholipase A2, PLA2
View Download 0.227 0.041 mitotic spindle organization in nucleus a.60.9 lambda integrase-like, N-terminal domain
View Download 0.226 0.041 mitotic spindle organization in nucleus a.2.7 tRNA-binding arm
View Download 0.225 0.041 mitotic spindle organization in nucleus a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.223 0.041 mitotic spindle organization in nucleus a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.221 0.041 mitotic spindle organization in nucleus a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.221 0.041 mitotic spindle organization in nucleus a.126.1 Serum albumin-like
View Download 0.221 0.041 mitotic spindle organization in nucleus a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.220 0.041 mitotic spindle organization in nucleus a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.218 0.041 mitotic spindle organization in nucleus a.126.1 Serum albumin-like
View Download 0.218 0.041 mitotic spindle organization in nucleus a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.217 0.041 mitotic spindle organization in nucleus d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.217 0.041 mitotic spindle organization in nucleus a.74.1 Cyclin-like
View Download 0.216 0.041 mitotic spindle organization in nucleus a.74.1 Cyclin-like
View Download 0.216 0.041 mitotic spindle organization in nucleus a.1.1 Globin-like
View Download 0.214 0.041 mitotic spindle organization in nucleus a.143.1 RNA polymerase omega subunit
View Download 0.212 0.041 mitotic spindle organization in nucleus a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.212 0.041 mitotic spindle organization in nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.210 0.041 mitotic spindle organization in nucleus a.48.2 Transferrin receptor ectodomain, C-terminal domain
View Download 0.204 0.041 mitotic spindle organization in nucleus a.47.2 t-snare proteins
View Download 0.204 0.041 mitotic spindle organization in nucleus a.126.1 Serum albumin-like
View Download 0.203 0.041 mitotic spindle organization in nucleus a.1.1 Globin-like
View Download 0.203 0.041 mitotic spindle organization in nucleus a.60.8 HRDC-like
View Download 0.203 0.041 mitotic spindle organization in nucleus a.83.1 Guanido kinase N-terminal domain
View Download 0.203 0.041 mitotic spindle organization in nucleus a.24.4 Hemerythrin
View Download 0.202 0.041 mitotic spindle organization in nucleus a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.202 0.041 mitotic spindle organization in nucleus a.7.1 Spectrin repeat
View Download 0.201 0.041 mitotic spindle organization in nucleus c.108.1 HAD-like
View Download 0.200 0.041 mitotic spindle organization in nucleus a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain

Predicted Domain #2
Region A:
Residues: [97-233]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTSAEEASRQ SQTDNGPNEA DSAVHVNRDV HSMFNNDSID DFHTANITST GQILKLPDSS  60
   61 DEDTGSEAVP SREQTDLTGE GHGGADDEQD ESTIQRQSRK RKISLLLQQQ YGSSSSMVPS 120
  121 PIVPNKMRKQ LAHEEHI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.322 0.028 mitotic spindle organization in nucleus d.110.4 SNARE-like
View Download 0.322 N/A N/A d.110.4 SNARE-like
View Download 0.282 N/A N/A d.110.4 SNARE-like
View Download 0.282 N/A N/A d.110.4 SNARE-like

Predicted Domain #3
Region A:
Residues: [234-292]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNDGDNDDEN SNNIESSPLK QGHHHPKGQA DDNNEGPDEE ESTKEVPKPG TIIHFSTNR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.371 a.4.5 "Winged helix" DNA-binding domain
View Download 0.212 a.156.1 S13-like H2TH domain
View Download 0.371 a.4.5 "Winged helix" DNA-binding domain
View Download 0.212 a.156.1 S13-like H2TH domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle