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View Structure Prediction Details

Protein: THI11
Organism: Saccharomyces cerevisiae
Length: 340 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THI11.

Description E-value Query
Range
Subject
Range
gi|157069916, gi... - gi|164423028|ref|XP_001728013.1| nmt1 protein, variant 2 [Neurospora crassa OR74A], gi|164423026|ref...
gi|15822513 - gi|15822513|gb|AAG23338.1| thiamine biosynthesis protein NMT-1 [Neurospora crassa]
1.0E-76 [1..338] [1..338]
THI13_YEAST - 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI13 OS=Saccharomyces cerevisiae (str...
gi|151945223, gi... - gi|151945223|gb|EDN63474.1| thiamine metabolism-related protein [Saccharomyces cerevisiae YJM789], g...
THI13 - Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a s...
gi|190409294, gi... - gi|190409294|gb|EDV12559.1| pyrimidine precursor biosynthesis enzyme THI13 [Saccharomyces cerevisiae...
3.0E-75 [1..340] [1..340]
gi|5777326 - gi|5777326|dbj|BAA83524.1| pyrimidine precursor biosynthesis enzyme [Candida tropicalis]
7.0E-72 [1..338] [1..338]
NMT1_ASPPA - 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase OS=Aspergillus parasiticus GN=nmt1 PE=...
4.0E-70 [1..336] [1..336]
gi|3282220 - gi|3282220|gb|AAC64375.1| thiamine synthase homolog [Botryotinia fuckeliana]
gi|154316628, gi... - gi|154316628|ref|XP_001557635.1| conserved hypothetical protein [Botryotinia fuckeliana B05.10], gi|...
5.0E-68 [1..336] [1..336]
NMT1_SCHPO - 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase OS=Schizosaccharomyces pombe (strain 9...
nmt1 - no message in thiamine Nmt1
5.0E-66 [1..332] [1..331]
NMT1_UROFA - 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase OS=Uromyces fabae GN=PIG1 PE=2 SV=1
2.0E-62 [1..332] [1..334]

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Predicted Domain #1
Region A:
Residues: [1-87]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTDKITFLL NWQPTPYHIP IFLAQTKGYF KEQGLDIAIL EPTNPSDVTE LIGSGKVDMG  60
   61 LKAMIHTLAA KARGFPVTSV ASLLDEP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [186-286]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RIDKLACLGC CCFCTVLYIC NDEFLKKNPE KVRKFLKAIK KATDYVLADP VKAWKEYIDF  60
   61 KPQLNNDLSY KQYQRCYAYF SSSLYNVHRD WKKVTGYGKR L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.0
Match: 1gggA_
Description: Glutamine-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [88-185]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTGVLYLKGS GITEDFQSLK GKKIGYVGEF GKIQIDELTK HYGMKPEDYT AVRCGMNVAK  60
   61 YIIEDKIDAG IGIECMQQVE LEEYLAKQGR PASDAKML

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.0
Match: 1gggA_
Description: Glutamine-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [287-340]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AILPPDYVSN YTNEYLSWPE PEEVSDPLEA QRLMAIHQEK CRQEGTFKRL ALPA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.353 a.4.5 "Winged helix" DNA-binding domain
View Download 0.393 a.4.1 Homeodomain-like
View Download 0.354 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.460 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.372 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.332 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.314 a.101.1 Uteroglobin-like
View Download 0.387 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.463 a.4.8 Ribosomal protein S18
View Download 0.298 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.452 a.140.3 Rho termination factor, N-terminal domain
View Download 0.413 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.446 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.421 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.358 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.346 a.101.1 Uteroglobin-like
View Download 0.342 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.335 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.316 a.5.2 UBA-like
View Download 0.303 a.157.1 Skp1 dimerisation domain-like
View Download 0.302 g.1.1 Insulin-like
View Download 0.300 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.300 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.300 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.297 f.13.1 Family A G protein-coupled receptor-like
View Download 0.295 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.285 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.284 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.279 a.4.8 Ribosomal protein S18
View Download 0.277 a.144.1 PABC (PABP) domain
View Download 0.273 f.13.1 Family A G protein-coupled receptor-like
View Download 0.271 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.271 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.267 f.13.1 Family A G protein-coupled receptor-like
View Download 0.257 a.4.5 "Winged helix" DNA-binding domain
View Download 0.243 a.157.1 Skp1 dimerisation domain-like
View Download 0.242 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.240 a.16.1 S15/NS1 RNA-binding domain
View Download 0.239 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.236 d.58.49 YajQ-like
View Download 0.234 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.231 a.60.1 SAM/Pointed domain
View Download 0.226 a.157.1 Skp1 dimerisation domain-like
View Download 0.224 a.4.1 Homeodomain-like
View Download 0.220 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.216 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.215 a.22.1 Histone-fold
View Download 0.213 a.60.1 SAM/Pointed domain
View Download 0.213 f.13.1 Family A G protein-coupled receptor-like
View Download 0.212 a.30.1 ROP protein
View Download 0.212 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.211 a.4.5 "Winged helix" DNA-binding domain
View Download 0.208 d.58.17 Metal-binding domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle