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View Structure Prediction Details

Protein: HOC1
Organism: Saccharomyces cerevisiae
Length: 396 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HOC1.

Description E-value Query
Range
Subject
Range
HOC1_YEAST - Putative glycosyltransferase HOC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HOC1 P...
gi|190409549 - gi|190409549|gb|EDV12814.1| mannosyltransferase [Saccharomyces cerevisiae RM11-1a]
HOC1 - Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localize...
0.0 [1..396] [1..396]
och1 - alpha-1,6-mannosyltransferase Och1
OCH1_SCHPO - Initiation-specific alpha-1,6-mannosyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24...
0.0 [13..389] [3..395]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
5.0E-95 [41..389] [1..365]
gi|17978673 - gi|17978673|gb|AAL49987.1| putative mannosyltransferase [Candida albicans]
6.0E-83 [75..389] [39..377]
gi|14161489 - gi|14161489|gb|AAK54761.1| putative mannosyltransferase [Paracoccidioides brasiliensis]
8.0E-51 [97..375] [63..336]
gi|18653302 - gi|18653302|gb|AAL77372.1|AF449195_7 putative glycosyl transferase [Vibrio cholerae]
8.0E-44 [88..322] [13..217]

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Predicted Domain #1
Region A:
Residues: [1-328]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKTTKRASS FRRLMIFAII ALISLAFGVR YLFHNSNATD LQKILQNLPK EISQSINSAN  60
   61 NIQSSDSDLV QHFESLAQEI RHQQEVQAKQ FDKQRKILEK KIQDLKQTPP EATLRERIAM 120
  121 TFPYDSHVKF PAFIWQTWSN DEGPERVQDI KGMWESKNPG FAHEVLNHDV INALVHHYFY 180
  181 SIPEILETYE ALPSIILKID FFKYLILLVH GGVYADIDTF PVQPIPNWIP EELSPSDIGL 240
  241 IVGVEEDAQR ADWRTKYIRR LQFGTWIIQA KPGHPVLREI ISRIIETTLQ RKRDDQLNVN 300
  301 LRNDLNIMSW TGSGLWTDTI FTYFNDFM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
UDP-glycosyltransferase activity 6.01354989568484 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 5.98555597307566 bayes_pls_golite062009
acetylgalactosaminyltransferase activity 5.66606808201136 bayes_pls_golite062009
alpha-1,2-mannosyltransferase activity 5.62955108548526 bayes_pls_golite062009
polypeptide N-acetylgalactosaminyltransferase activity 5.60505224219681 bayes_pls_golite062009
mannosyltransferase activity 5.1732667004955 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 4.02812104984198 bayes_pls_golite062009
transferase activity 2.3313878748424 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.79751747857925 bayes_pls_golite062009
catalytic activity 1.73979371332125 bayes_pls_golite062009
nucleotidyltransferase activity 1.47767908405723 bayes_pls_golite062009
N-acetyllactosamine synthase activity 0.925872529464618 bayes_pls_golite062009
lactose synthase activity 0.925872529464618 bayes_pls_golite062009
cytidylyltransferase activity 0.450701661234496 bayes_pls_golite062009
alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity 0.386636074342689 bayes_pls_golite062009
binding 0.165472828059574 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [329-396]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSGVREKVTW KLFHNLNQPK LLSDVLVFPK FSFNCPNQID NDDPHKKFYF ITHLASQFWK  60
   61 NTPKVEQK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.585 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.498 a.2.7 tRNA-binding arm
View Download 0.381 a.140.4 Recombination endonuclease VII, C-terminal and dimerization domains
View Download 0.443 a.112.1 Description not found.
View Download 0.380 a.16.1 S15/NS1 RNA-binding domain
View Download 0.368 c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.366 a.3.1 Cytochrome c
View Download 0.352 a.144.1 PABC (PABP) domain
View Download 0.349 a.4.1 Homeodomain-like
View Download 0.337 a.64.1 Saposin
View Download 0.335 a.30.1 ROP protein
View Download 0.333 a.65.1 Annexin
View Download 0.325 a.50.1 Anaphylotoxins (complement system)
View Download 0.324 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.319 i.1.1 Ribosome and ribosomal fragments
View Download 0.267 a.6.1 Putative DNA-binding domain
View Download 0.254 a.6.1 Putative DNA-binding domain
View Download 0.253 a.60.11 Hypothetical protein YjbJ
View Download 0.239 a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.228 a.7.6 Ribosomal protein S20
View Download 0.223 g.57.1 Serine proteinase inhibitor lekti
View Download 0.219 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.217 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.213 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.212 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.211 a.144.2 Ribosomal protein L20
View Download 0.205 d.141.1 Ribosomal protein L6
View Download 0.203 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.203 a.5.1 DNA helicase RuvA subunit, C-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle