YRC Public Data Repository - Protein Structure Prediction

Protein:	NTA1
Organism:	Saccharomyces cerevisiae
Length:	457 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NTA1.

Description	E-value	Query Range	Subject Range
NTA1 - Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate prote... NTA1_YEAST - Protein N-terminal amidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NTA1 PE=1 SV=...	0.0	[1..457]	[1..457]
NIT2 - nitrilase family, member 2	2.0E-65	[16..287]	[1..269]
NIT2_MOUSE - Omega-amidase NIT2 OS=Mus musculus GN=Nit2 PE=1 SV=1	1.0E-64	[16..289]	[1..271]
AGUB_SOLLC - N-carbamoylputrescine amidase OS=Solanum lycopersicum GN=CPA PE=2 SV=1	3.0E-64	[19..297]	[8..297]
gi\|18401429, gi\|... - gi\|222424030\|dbj\|BAH19976.1\| AT2G27450 [Arabidopsis thaliana], gi\|21554187\|gb\|AAM63266.1\| putative n...	5.0E-64	[14..295]	[5..297]
gi\|7449038 - pir\|\|B69109 N-carbamoyl-D-amino acid amidohydrolase - Methanobacterium thermoautotrophicum (strain D... gi\|15679799, gi\|... - gi\|2622943\|gb\|AAB86277.1\| N-carbamoyl-D-amino acid amidohydrolase [Methanothermobacter thermautotrop...	1.0E-62	[19..288]	[1..267]
gi\|225726488, gi... - gi\|225861184\|ref\|YP_002742693.1\| N-carbamoylputrescine amidase [Streptococcus pneumoniae Taiwan19F-1... gi\|225858720, gi... - gi\|225858720\|ref\|YP_002740230.1\| N-carbamoylputrescine amidase [Streptococcus pneumoniae 70585], gi\|... gi\|225725231, gi... - gi\|225856586\|ref\|YP_002738097.1\| N-carbamoylputrescine amidase [Streptococcus pneumoniae P1031], gi\|... gi\|225854429, gi... - gi\|225854429\|ref\|YP_002735941.1\| N-carbamoylputrescine amidase [Streptococcus pneumoniae JJA], gi\|22... gi\|147764916, gi... - gi\|149010435\|ref\|ZP_01831806.1\| carbon-nitrogen hydrolase family protein [Streptococcus pneumoniae S... gi\|147930884, gi... - gi\|149019509\|ref\|ZP_01834828.1\| carbon-nitrogen hydrolase family protein [Streptococcus pneumoniae S... gi\|147759404, gi... - gi\|149002467\|ref\|ZP_01827401.1\| carbon-nitrogen hydrolase family protein [Streptococcus pneumoniae S... gi\|147762180, gi... - gi\|149006403\|ref\|ZP_01830115.1\| carbon-nitrogen hydrolase family protein [Streptococcus pneumoniae S... gi\|14972396, gi\|... - gi\|66878278\|ref\|ZP_00403767.1\| COG0388: Predicted amidohydrolase [Streptococcus pneumoniae TIGR4], g... gi\|194398116, gi... - gi\|194398116\|ref\|YP_002037559.1\| N-carbamoylputrescine amidase [Streptococcus pneumoniae G54], gi\|19... gi\|25320753 - pir\|\|E95106 carbon-nitrogen hydrolase family protein [imported] - Streptococcus pneumoniae (strain T... gi\|168485872, gi... - gi\|183571035\|gb\|EDT91563.1\| N-carbamoylputrescine amidase [Streptococcus pneumoniae CDC1087-00], gi\|... gi\|168491010, gi... - gi\|183574681\|gb\|EDT95209.1\| N-carbamoylputrescine amidase [Streptococcus pneumoniae CDC0288-04], gi\|... gi\|183578517, gi... - gi\|183578517\|gb\|EDT99045.1\| N-carbamoylputrescine amidase [Streptococcus pneumoniae MLV-016], gi\|168... gi\|169833217, gi... - gi\|169833217\|ref\|YP_001694375.1\| N-carbamoylputrescine amidase [Streptococcus pneumoniae Hungary19A-... gi\|182683869, gi... - gi\|182683869\|ref\|YP_001835616.1\| carbon-nitrogen hydrolase family protein [Streptococcus pneumoniae ... gi\|147928397, gi... - gi\|148992945\|ref\|ZP_01822564.1\| carbon-nitrogen hydrolase family protein [Streptococcus pneumoniae S... gi\|148996986, gi... - gi\|148996986\|ref\|ZP_01824640.1\| carbon-nitrogen hydrolase family protein [Streptococcus pneumoniae S... gi\|147923055, gi... - gi\|148984664\|ref\|ZP_01817932.1\| carbon-nitrogen hydrolase family protein [Streptococcus pneumoniae S... gi\|242236240, gi... - gi\|242245204\|ref\|ZP_04799641.1\| N-carbamoylputrescine amidase [Streptococcus pneumoniae TCH8431/19A]... gi\|237821877 - gi\|237821877\|ref\|ZP_04597722.1\| N-carbamoylputrescine amidase [Streptococcus pneumoniae CCRI 1974M2] gi\|237651125 - gi\|237651125\|ref\|ZP_04525377.1\| N-carbamoylputrescine amidase [Streptococcus pneumoniae CCRI 1974]	2.0E-62	[16..288]	[1..287]
gi\|15839034, gi\|... - gi\|9107636\|gb\|AAF85242.1\|AE004053_5 beta-alanine synthetase [Xylella fastidiosa 9a5c], gi\|15839034\|r... gi\|11279690 - pir\|\|H82556 beta-alanine synthetase XF2443 [imported] - Xylella fastidiosa (strain 9a5c)	2.0E-62	[21..292]	[8..291]

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Predicted Domain #1

Region A:
Residues: [1-342]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIDAIHGAK MSTKLLVSLK VLVIQLNPQI GQVDQTIKRT WSILDKVTKS ATYVKPDIIL  60
   61 FPEFALTGYS FHARKDILPY VTKKDEGPSF ELAKSISEKF QCYTIIGYPE DDDEQKLYNS 120
  121 ALVVNPQGEQ IFNYRKTFLY DTEMNWDCEE NPEGFQTFPM DFSKCAKLSN EDSYNRDVTL 180
  181 KASIGICMDL SPYKFMAPFN HFEFSSFCVD NNVELILCPM AWLNSTSITD KQTLHNNSLL 240
  241 EAAKNKIAFA LKEQGLPLAG SQGIYQLKIG DSQRTPRVPS DDSTSEYKDM DEPDMSNVNY 300
  301 WILRFFPFLY FKSRINWFKN SSLIESILGK TRMPLDHEYY KD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	113.045757
Match:	1f89A_
Description:	hypothetical protein yl85
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [343-457]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKHKEDTIDL LDSEEVIKDT VLEKTFLGTS LGQPWKFQGK NAILVLANRC GTEDGTTIFA  60
   61 GSSGIYKFNG KKPKGSQDDD ESSLDSLNES VELLGNLGKG LEGAILREVQ FEVFR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.588	a.24.3	Cytochromes
View	Download	0.560	a.25.1	Ferritin-like
View	Download	0.490	a.36.1	Signal peptide-binding domain
View	Download	0.588	a.24.3	Cytochromes
View	Download	0.560	a.25.1	Ferritin-like
View	Download	0.533	a.24.3	Cytochromes
View	Download	0.511	d.44.1	Fe,Mn superoxide dismutase (SOD), C-terminal domain
View	Download	0.511	d.44.1	Fe,Mn superoxide dismutase (SOD), C-terminal domain
View	Download	0.490	a.36.1	Signal peptide-binding domain
View	Download	0.441	a.24.4	Hemerythrin
View	Download	0.420	a.1.1	Globin-like
View	Download	0.400	d.129.1	TATA-box binding protein-like
View	Download	0.390	d.14.1	Ribosomal protein S5 domain 2-like
View	Download	0.387	a.29.2	Bromodomain
View	Download	0.385	b.60.1	Lipocalins
View	Download	0.378	d.233.1	Inhibitor of vertebrate lysozyme, Ivy
View	Download	0.362	d.52.4	YhbC-like, N-terminal domain
View	Download	0.341	a.90.1	Transcription factor STAT-4 N-domain
View	Download	0.341	d.110.4	SNARE-like
View	Download	0.340	a.118.8	TPR-like
View	Download	0.317	d.189.1	PX domain
View	Download	0.316	d.82.2	Frataxin-like
View	Download	0.316	b.1.10	Clathrin adaptor appendage domain
View	Download	0.304	d.104.1	Class II aaRS and biotin synthetases
View	Download	0.299	b.1.2	Fibronectin type III
View	Download	0.298	a.40.1	Calponin-homology domain, CH-domain
View	Download	0.290	d.129.1	TATA-box binding protein-like
View	Download	0.277	d.16.1	FAD-linked reductases, C-terminal domain
View	Download	0.254	a.118.9	ENTH/VHS domain
View	Download	0.246	f.1.4	Bcl-2 inhibitors of programmed cell death
View	Download	0.238	d.101.1	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
View	Download	0.207	a.118.13	Arp2/3 complex 16 kDa subunit ARPC5

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits