YRC Public Data Repository - Protein Structure Prediction

Protein:	YJL163C
Organism:	Saccharomyces cerevisiae
Length:	555 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YJL163C.

Description	E-value	Query Range	Subject Range
gi\|25498023 - pir\|\|D96902 MDR-type permease [imported] - Clostridium acetobutylicum gi\|15893318, gi\|... - gi\|15893318\|ref\|NP_346667.1\| MDR-type permease [Clostridium acetobutylicum ATCC 824], gi\|15022839\|gb...	2.0E-68	[73..520]	[1..417]
gi\|15927932, gi\|... - gi\|15927932\|ref\|NP_375465.1\| hypothetical protein SA2142 [Staphylococcus aureus subsp. aureus N315],... gi\|253314692 - gi\|253314692\|ref\|ZP_04837905.1\| hypothetical protein SauraC_00665 [Staphylococcus aureus subsp. aure... gi\|12003106, gi\|... - pir\|\|C90035 hypothetical protein SA2142 [imported] - Staphylococcus aureus (strain N315), gi\|120031... gi\|255007128 - gi\|255007128\|ref\|ZP_05145729.2\| hypothetical protein SauraM_11685 [Staphylococcus aureus subsp. aure... gi\|14248126, gi\|... - gi\|15925342\|ref\|NP_372876.1\| multidrug resistance protein [Staphylococcus aureus subsp. aureus Mu50]... gi\|269203983\|ref... - EmrB/QacA family drug resistance transporter [Staphylococcus aureus subsp. aureus ED98] gi\|90583610, gi\|... - gi\|90583610\|ref\|ZP_01239364.1\| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu... gi\|147741858, gi... - gi\|90585929\|ref\|ZP_01241634.1\| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu... gi\|156980667, gi... - gi\|156980667\|ref\|YP_001442926.1\| hypothetical protein SAHV_2336 [Staphylococcus aureus subsp. aureus...	5.0E-67	[5..511]	[60..540]
gi\|21225257, gi\|... - gi\|7649556\|emb\|CAB89031.1\| putative membrane transport protein. [Streptomyces coelicolor A3(2)], gi\|...	5.0E-67	[56..520]	[10..443]
lcl\|NC_016856.1_... - [gene=emrB] [protein=putative multidrug transport protein] [protein_id=YP_005238915.1] [location=298... gi\|16766126, gi\|... - gi\|16766126\|ref\|NP_461741.1\| putative multidrug transport protein [Salmonella typhimurium LT2], gi\|1... gi\|167992539, gi... - gi\|205329344\|gb\|EDZ16108.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica sero...	5.0E-64	[73..524]	[1..430]
gi\|16761596 - gi\|16761596\|ref\|NP_457213.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|25306158, gi\|... - gi\|25306158\|pir\|\|AG0842 multidrug resistance protein B [imported] - Salmonella enterica subsp. enter... gi\|29138709, gi\|... - gi\|29143076\|ref\|NP_806418.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|213850377 - gi\|213850377\|ref\|ZP_03381275.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ... gi\|214000013 - gi\|214000013\|ref\|ZP_03410748.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ...	5.0E-64	[73..524]	[1..430]
gi\|15528453 - gi\|15528453\|emb\|CAC69145.1\| putative membrane protein [Pichia anomala]	1.0E-63	[5..520]	[20..518]
gi\|229896373, gi... - gi\|229896373\|ref\|ZP_04511542.1\| multidrug resistance protein B [Yersinia pestis Pestoides A], gi\|229... gi\|229899449, gi... - gi\|229899449\|ref\|ZP_04514592.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|165926632, gi... - gi\|165926632\|ref\|ZP_02222464.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|22124829, gi\|... - gi\|22124829\|ref\|NP_668252.1\| multidrug resistance protein B [Yersinia pestis KIM], gi\|21957657\|gb\|AA... gi\|166213072, gi... - gi\|166213072\|ref\|ZP_02239107.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|25306154 - pir\|\|AB0397 multidrug resistance protein B [imported] - Yersinia pestis (strain CO92) gi\|165990079, gi... - gi\|166011079\|ref\|ZP_02231977.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|51595205, gi\|... - gi\|51595205\|ref\|YP_069396.1\| MFS multidrug efflux pump, emrB subunit [Yersinia pseudotuberculosis IP... gi\|45435371, gi\|... - gi\|45440514\|ref\|NP_992053.1\| multidrug resistance protein B [Yersinia pestis biovar Microtus str. 91... gi\|218930293, gi... - gi\|218930293\|ref\|YP_002348168.1\| multidrug resistance protein B [Yersinia pestis CO92], gi\|16123425\|... gi\|149364891, gi... - gi\|149364891\|ref\|ZP_01886926.1\| multidrug resistance protein B [Yersinia pestis CA88-4125], gi\|14929... gi\|145211859, gi... - gi\|145600163\|ref\|YP_001164239.1\| multidrug resistance protein B [Yersinia pestis Pestoides F], gi\|14... gi\|167421612, gi... - gi\|167421612\|ref\|ZP_02313365.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|167051986, gi... - gi\|167399482\|ref\|ZP_02305006.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|170025556, gi... - gi\|170025556\|ref\|YP_001722061.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|167057491, gi... - gi\|167423321\|ref\|ZP_02315074.1\| multidrug resistance protein B [Yersinia pestis biovar Mediaevalis s... gi\|162354357, gi... - gi\|77633286\|ref\|ZP_00795425.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... gi\|89103813, gi\|... - gi\|89103813\|ref\|ZP_01176376.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... Q66E38\|Q66E38_YERPS - MFS multidrug efflux pump, emrB subunit - Yersinia pseudotuberculosis gi\|186894223, gi... - gi\|186894223\|ref\|YP_001871335.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|153950510, gi... - gi\|77631828\|ref\|ZP_00794414.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pse... gi\|108808750, gi... - gi\|108808750\|ref\|YP_652666.1\| multidrug resistance protein B [Yersinia pestis Antiqua], gi\|108780663... gi\|229901211, gi... - gi\|229901211\|ref\|ZP_04516333.1\| multidrug resistance protein B [Yersinia pestis Nepal516], gi\|229681... gi\|229695246, gi... - gi\|229838880\|ref\|ZP_04459039.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st...	1.0E-62	[77..524]	[4..429]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-62	[53..535]	[18..474]
gi\|7473474 - pir\|\|H75577 probable drug transport protein - Deinococcus radiodurans (strain R1) gi\|15807911, gi\|... - gi\|6460686\|gb\|AAF12391.1\|AE001863_16 drug transport protein, putative [Deinococcus radiodurans R1], ...	5.0E-62	[46..521]	[1..455]

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Predicted Domain #1

Region A:
Residues: [1-70]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNEDETTRL MSSDEMDYLL ETAGINALEE IISQNDSTGI NLDTNETAQD SSYDSIRRSP  60
   61 SILSVAKSVE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.321	a.35.1	lambda repressor-like DNA-binding domains
View	Download	0.318	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.304	a.60.8	HRDC-like
View	Download	0.295	d.120.1	Cytochrome b5
View	Download	0.256	d.58.7	RNA-binding domain, RBD
View	Download	0.252	a.35.1	lambda repressor-like DNA-binding domains
View	Download	0.251	d.51.1	Eukaryotic type KH-domain (KH-domain type I)
View	Download	0.241	a.112.1	Description not found.
View	Download	0.225	a.144.2	Ribosomal protein L20
View	Download	0.225	a.4.1	Homeodomain-like
View	Download	0.215	a.60.7	5' to 3' exonuclease, C-terminal subdomain
View	Download	0.215	a.60.13	Putative methyltransferase TM0872, insert domain

Predicted Domain #2

Region A:
Residues: [71-280]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEHGRRKLLC LYGLVMIICI AESISMTATI PLVMDKVAEG ISDENGHYDS VAVQTIVSSI  60
   61 SSSTMMIAGA ISIFMAGKWG ELSDRIGRVR VFKYMSGIRV IGLLTHVFTL SSKMKYHKWA 120
  121 IVLTACIVPS FGGLFALVAN GNSYVSDIVK TEHRMVTIGI MMSCIYATMG VGPMFGSFLV 180
  181 KWTHGNGFIP IYTSIAFVIL ALIICETIMV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [339-555]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKPDSAGSLV PRHTVILLIV LDILFVCGTT SCMPALILFS TYEYKWHAVE LGYFISILGI  60
   61 GRGVVLLVVS PTLLYTLKRI YQHLNHSIDK IDIFCIQFSM IVITLSLFVM IRFGEKTPTS 120
  121 MIIFALLQAL SAFCSPTLQS GIIKYTSKKH TGEMFGAMAL VRSCVMLVIP PILLKLYGST 180
  181 VSVNPSLFMY IPFSTSIVAI LLTFFLRIYK NPPLDGP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.69897
Match:	1ja5A_
Description:	No description for 1ja5A_ was found.

Predicted Domain #3

Region A:
Residues: [281-338]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPRHETQMAH SQSTYTKRRE KLRSQSGSDD ARNYQSVTYG KFQIMRLMDL LAPVKKLW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.69897
Match:	1ja5A_
Description:	No description for 1ja5A_ was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits