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View Structure Prediction Details

Protein: GYP6
Organism: Saccharomyces cerevisiae
Length: 458 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GYP6.

Description E-value Query
Range		 Subject
Range
GYP6_YEAST - GTPase-activating protein GYP6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GYP6 PE=1...
GYP6 - GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated...
 0.0 [1..458] [1..458]
TB10A_MOUSE - TBC1 domain family member 10A OS=Mus musculus GN=Tbc1d10a PE=1 SV=1
 5.0E-55 [66..381] [79..363]
TBC1D10A - TBC1 domain family, member 10A
gi|114685826 - gi|114685826|ref|XP_001139921.1| PREDICTED: TBC1 domain family, member 10A isoform 6 [Pan troglodyte...
gi|148744794 - gi|148744794|gb|AAI43053.1| TBC1 domain family, member 10A [synthetic construct]
 8.0E-55 [66..381] [79..363]
gi|13874508 - gi|13874508|dbj|BAB46876.1| hypothetical protein [Macaca fascicularis]
 5.0E-52 [53..378] [133..470]

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Predicted Domain #1
Region A:
Residues: [1-82] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKDVLQWAID HYETRDQLVQ KGIWKGELYH DSIFKENSRG WLWKALLLCD ENNNCLLTDN  60
   61 FKGLDLNQFG LVPVPMLADG DN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [83-238] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDENHNANVP KRVLHSNVSS SVGIRRLTPV EAVEKHPLSD DNDKTKGSLS KGSDEKPLTL  60
   61 RETLEIIDLD LSRIMLDDIF QEPKVHAQMR QLLYNYLLIH QSEHLQYKQG FHEILSVIYL 120
  121 QLYHGTDLDN TDLQNVLIIF NKLMNQIEPI FYNEEN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [307-348] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVWDHVLTFN YPLDIFIACT IITLLLSIYD ELHELVSQGD YE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.39794
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [239-306] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LINWDKRVFT KIFRICLPDL FSKVFYQPPK TGSGKKKNVD HLIHSNLIWL IRWTRLLFLR  60
   61 ELPLKYVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.39794
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [349-458] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HTNNNDEFVE LILHFKKIFE KEDASKDDEK FLDLCKVTGN LCELWYGKNY DDMRLICDTF  60
   61 INAKFGIKTS DVLSMETAKL TIDPNRQSLE NKLRERVRQT ILKNKKKISQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.804 0.007 GTPase activator activity a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases

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