YRC Public Data Repository - Protein Structure Prediction

Protein:	SEC11
Organism:	Saccharomyces cerevisiae
Length:	167 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEC11.

Description	E-value	Query Range	Subject Range
SC11C_MOUSE - Signal peptidase complex catalytic subunit SEC11C OS=Mus musculus GN=Sec11c PE=1 SV=3 gi\|149064491 - gi\|149064491\|gb\|EDM14694.1\| Sec11-like 3 (S. cerevisiae), isoform CRA_c [Rattus norvegicus]	4.0E-48	[1..167]	[25..191]
gi\|194214714 - gi\|194214714\|ref\|XP_001489335.2\| PREDICTED: similar to Signal peptidase complex catalytic subunit SE... tr\|M3W609\|M3W609... - Signal peptidase complex catalytic subunit SEC11 OS=Felis catus GN=SEC11C PE=3 SV=1 SC11C_CANLF - Signal peptidase complex catalytic subunit SEC11C OS=Canis lupus familiaris GN=SEC11C PE=1 SV=3	6.0E-48	[1..167]	[25..191]
SEC11C - SEC11 homolog C (S. cerevisiae) SC11C_PONAB - Signal peptidase complex catalytic subunit SEC11C OS=Pongo abelii GN=SEC11C PE=2 SV=3 SC11C_PONPY, SPC... - Microsomal signal peptidase 21 kDa subunit (EC 3.4.-.-) (SPase 21 kDa subunit) (SPC21) (SEC11-like 3...	7.0E-48	[1..167]	[25..191]
SC11C_RAT - Signal peptidase complex catalytic subunit SEC11C OS=Rattus norvegicus GN=Sec11c PE=2 SV=3	2.0E-47	[1..167]	[25..191]
SEC11_YEAS2 - Signal peptidase complex catalytic subunit SEC11 OS=Saccharomyces cerevisiae (strain JAY291) GN=SEC1... SEC11_YEASL - Signal peptidase complex catalytic subunit SEC11 OS=Saccharomyces cerevisiae (strain Lalvin QA23) GN... SEC11_YEAS7 - Signal peptidase complex catalytic subunit SEC11 OS=Saccharomyces cerevisiae (strain YJM789) GN=SEC1... SEC11_YEASB - Signal peptidase complex catalytic subunit SEC11 OS=Saccharomyces cerevisiae (strain FostersB) GN=SE... SEC11_YEASA - Signal peptidase complex catalytic subunit SEC11 OS=Saccharomyces cerevisiae (strain AWRI796) GN=SEC... SEC11_YEAS8 - Signal peptidase complex catalytic subunit SEC11 OS=Saccharomyces cerevisiae (strain Lalvin EC1118 /... SEC11_YEASZ - Signal peptidase complex catalytic subunit SEC11 OS=Saccharomyces cerevisiae (strain Zymaflore VL3) ... SEC11 - 18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which... SEC11_YEASV - Signal peptidase complex catalytic subunit SEC11 OS=Saccharomyces cerevisiae (strain VIN 13) GN=SEC1... SEC11_YEAST - Signal peptidase complex catalytic subunit SEC11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S... SEC11_YEAS1 - Signal peptidase complex catalytic subunit SEC11 OS=Saccharomyces cerevisiae (strain RM11-1a) GN=SEC...	2.0E-47	[1..167]	[1..167]
gi\|195568779, gi... - gi\|195568779\|ref\|XP_002102391.1\| GD19887 [Drosophila simulans], gi\|194198318\|gb\|EDX11894.1\| GD19887 ... gi\|220942718 - gi\|220942718\|gb\|ACL83902.1\| Spase18-21-PA [synthetic construct] gi\|195344031, gi... - gi\|195344031\|ref\|XP_002038594.1\| GM10908 [Drosophila sechellia], gi\|194133615\|gb\|EDW55131.1\| GM10908... gi\|195498966, gi... - gi\|195498966\|ref\|XP_002096749.1\| GE24877 [Drosophila yakuba], gi\|194182850\|gb\|EDW96461.1\| GE24877 [D... gi\|190650805, gi... - gi\|194899103\|ref\|XP_001979102.1\| GG13600 [Drosophila erecta], gi\|190650805\|gb\|EDV48060.1\| GG13600 [D... Spase18-21-PA - The gene Spase 18/21-subunit is referred to in FlyBase by the symbol Dmel\Spase18-21 (CG2358, FBgn00...	4.0E-47	[1..167]	[19..185]
CE22466 - status:Confirmed UniProt:Q9N3D0 protein_id:AAF59551.1	2.0E-45	[1..167]	[16..182]

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Predicted Domain #1

Region A:
Residues: [1-115]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLRFELQKL LNVCFLFASA YMFWQGLAIA TNSASPIVVV LSGSMEPAFQ RGDILFLWNR  60
   61 NTFNQVGDVV VYEVEGKQIP IVHRVLRQHN NHADKQFLLT KGDNNAGNDI SLYAN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.045757
Match:	1b12A_
Description:	Type 1 signal peptidase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [116-167]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKIYLNKSKE IVGTVKGYFP QLGYITIWIS ENKYAKFALL GMLGLSALLG GE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits