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View Structure Prediction Details

Protein: MCM10
Organism: Saccharomyces cerevisiae
Length: 571 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCM10.

Description E-value Query
Range
Subject
Range
MCM10 - Essential chromatin-associated protein involved in the initiation of DNA replication; required for t...
gi|151943016 - gi|151943016|gb|EDN61351.1| minichromosome maintenance-related protein [Saccharomyces cerevisiae YJM...
MCM10_YEAST - Minichromosome maintenance protein 10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MC...
0.0 [1..571] [1..571]
gi|33383235, gi|... - gi|55958695|emb|CAI16558.1| minichromosome maintenance complex component 10 [Homo sapiens], gi|55957...
0.0 [20..561] [109..592]
MCM10_XENLA - Protein MCM10 homolog OS=Xenopus laevis GN=mcm10 PE=1 SV=2
0.0 [19..566] [97..585]
cdc23 - MCM-associated protein Mcm10
MCM10_SCHPO - DNA replication licensing factor mcm10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mcm...
6.0E-98 [22..355] [8..344]
CE24338 - status:Partially_confirmed UniProt:Q9U2C2 protein_id:CAB57900.1
9.0E-84 [24..356] [5..313]

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Predicted Domain #1
Region A:
Residues: [1-364]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDPREILAV DPYNNITSDE EDEQAIAREL EFMERKRQAL VERLKRKQEF KKPQDPNFEA  60
   61 IEVPQSPTKN RVKVGSHNAT QQGTKFEGSN INEVRLSQLQ QQPKPPASTT TYFMEKFQNA 120
  121 KKNEDKQIAK FESMMNARVH TFSTDEKKYV PIITNELESF SNLWVKKRYI PEDDLKRALH 180
  181 EIKILRLGKL FAKIRPPKFQ EPEYANWATV GLISHKSDIK FTSSEKPVKF FMFTITDFQH 240
  241 TLDVYIFGKK GVERYYNLRL GDVIAILNPE VLPWRPSGRG NFIKSFNLRI SHDFKCILEI 300
  301 GSSRDLGWCP IVNKKTHKKC GSPINISLHK CCDYHREVQF RGTSAKRIEL NGGYALGAPT 360
  361 KVDS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [365-459]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPSLYKAKGE NGFNIIKGTR KRLSEEEERL KKSSHNFTNS NSAKAFFDEK FQNPDMLANL  60
   61 DNKRRKIIET KKSTALSREL GKIMRRRESS GLEDK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.362 a.74.1 Cyclin-like
View Download 0.375 a.40.1 Calponin-homology domain, CH-domain
View Download 0.415 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.517 a.7.6 Ribosomal protein S20
View Download 0.375 a.7.6 Ribosomal protein S20
View Download 0.355 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.352 a.39.1 EF-hand
View Download 0.336 a.39.1 EF-hand
View Download 0.328 a.85.1 Hemocyanin, N-terminal domain
View Download 0.323 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.311 a.3.1 Cytochrome c
View Download 0.298 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.290 a.29.2 Bromodomain
View Download 0.285 a.4.5 "Winged helix" DNA-binding domain
View Download 0.265 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.260 a.4.1 Homeodomain-like
View Download 0.257 a.39.1 EF-hand
View Download 0.252 a.118.8 TPR-like
View Download 0.249 a.61.1 Retroviral matrix proteins
View Download 0.242 a.40.1 Calponin-homology domain, CH-domain
View Download 0.239 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.233 a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.232 a.39.1 EF-hand
View Download 0.229 a.24.17 Group V grass pollen allergen
View Download 0.212 a.4.5 "Winged helix" DNA-binding domain
View Download 0.209 d.188.1 Prokaryotic ribosomal protein L17
View Download 0.208 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.207 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.207 a.4.1 Homeodomain-like
View Download 0.204 a.16.1 S15/NS1 RNA-binding domain
View Download 0.204 a.3.1 Cytochrome c
View Download 0.202 a.144.1 PABC (PABP) domain
View Download 0.201 d.4.1 His-Me finger endonucleases

Predicted Domain #3
Region A:
Residues: [460-571]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVGERQKMKR TTESALQTGL IQRLGFDPTH GKISQVLKSS VSGSEPKNNL LGKKKTVIND  60
   61 LLHYKKEKVI LAPSKNEWFK KRSHREEVWQ KHFGSKETKE TSDGSASDLE II

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.362 0.077 chromatin silencing at silent mating-type cassette a.74.1 Cyclin-like
View Download 0.375 0.072 chromatin silencing at silent mating-type cassette a.40.1 Calponin-homology domain, CH-domain
View Download 0.415 0.027 chromatin silencing at silent mating-type cassette a.60.9 lambda integrase-like, N-terminal domain
View Download 0.374 0.026 DNA replication initiation a.74.1 Cyclin-like
View Download 0.517 0.011 chromatin silencing at silent mating-type cassette a.7.6 Ribosomal protein S20
View Download 0.375 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.356 N/A N/A a.74.1 Cyclin-like
View Download 0.306 N/A N/A a.77.1 DEATH domain
View Download 0.263 N/A N/A a.74.1 Cyclin-like
View Download 0.235 N/A N/A a.118.15 Aconitase B, N-terminal domain
View Download 0.202 N/A N/A a.74.1 Cyclin-like

Predicted Domain #4
Region A:
Residues: [487-571]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTHGKISQVL KSSVSGSEPK NNLLGKKKTV INDLLHYKKE KVILAPSKNE WFKKRSHREE  60
   61 VWQKHFGSKE TKETSDGSAS DLEII

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.374 0.061 chromatin silencing at silent mating-type cassette a.74.1 Cyclin-like
View Download 0.356 N/A N/A a.74.1 Cyclin-like
View Download 0.339 N/A N/A a.74.1 Cyclin-like
View Download 0.328 N/A N/A a.74.1 Cyclin-like
View Download 0.315 N/A N/A a.74.1 Cyclin-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle