YRC Public Data Repository - Protein Structure Prediction

Protein:	DFG10
Organism:	Saccharomyces cerevisiae
Length:	253 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DFG10.

Description	E-value	Query Range	Subject Range
gi\|109076702 - gi\|109076702\|ref\|XP_001083405.1\| PREDICTED: similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Ster... S5A1_MACFA - 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Macaca fascicularis GN=SRD5A1 PE=1 SV=1	6.0E-55	[5..252]	[7..262]
gi\|151943110 - gi\|151943110\|gb\|EDN61445.1\| conserved protein [Saccharomyces cerevisiae YJM789] DFG10 - Protein of unknown function, involved in filamentous growth DFG10_YEAST - Polyprenol reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DFG10 PE=1 SV=1	7.0E-55	[1..253]	[1..253]
SRD5A1 - steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) gi\|61361219, gi\|... - gi\|61361219\|gb\|AAX42014.1\| steroid-5-alpha-reductase alpha polypeptide 1 [synthetic construct], gi\|6... gi\|114598928 - gi\|114598928\|ref\|XP_001144570.1\| PREDICTED: steroid-5-alpha-reductase 1 isoform 2 [Pan troglodytes]	2.0E-54	[9..252]	[7..258]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	3.0E-52	[1..253]	[1..255]
S5A1_RAT - 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Rattus norvegicus GN=Srd5a1 PE=1 SV=2 gi\|1336835 - gi\|1336835\|gb\|AAB36218.1\| type I 5 alpha-reductase [Rattus sp.]	3.0E-52	[1..253]	[5..259]
TECR_MOUSE - Very-long-chain enoyl-CoA reductase OS=Mus musculus GN=Tecr PE=1 SV=1	2.0E-50	[26..253]	[34..308]

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Predicted Domain #1

Region A:
Residues: [1-63]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYFDEEQLLK YTIYAYRLSF FVGICSLFIA KSCLPEFLQY GKTYRPKENS KYSSILERIK  60
   61 KFT

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.806	N/A	N/A	a.60.1	SAM/Pointed domain
View	Download	0.669	N/A	N/A	a.60.1	SAM/Pointed domain
View	Download	0.663	N/A	N/A	a.164.1	C-terminal domain of DFF45/ICAD (DFF-C domain)
View	Download	0.592	N/A	N/A	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View	Download	0.560	N/A	N/A	a.60.1	SAM/Pointed domain

Predicted Domain #2

Region A:
Residues: [64-253]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPKAYFSHFY YLATFLSLVT LYFYPKFPIV WIIFGHSLRR LYETLYVLHY TSNSRMNWSH  60
   61 YLVGIWFYSV LLLILNISLY KNSIPNTLNM NAFIIFCIAS WDQYKNHVIL ANLVKYSLPT 120
  121 GRLFRLVCCP HYLDEIIIYS TLLPYEQEFY LTLVWVITSL TISALETKNY YRHKFKDNHV 180
  181 APYAIIPFII

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	4.886057
Match:	PF02544
Description:	3-oxo-5-alpha-steroid 4-dehydrogenase

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits