YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS6
Organism:	Saccharomyces cerevisiae
Length:	261 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS6.

Description	E-value	Query Range	Subject Range
HIS6_AQUAE - Imidazole glycerol phosphate synthase subunit HisF OS=Aquifex aeolicus GN=hisF PE=3 SV=1 HIS6_AQUAE - Imidazole glycerol phosphate synthase subunit HisF OS=Aquifex aeolicus (strain VF5) GN=hisF PE=3 SV=...	5.0E-75	[3..261]	[5..246]
HIS6_AZOBR - Imidazole glycerol phosphate synthase subunit HisF OS=Azospirillum brasilense GN=hisF PE=3 SV=1	8.0E-75	[3..261]	[5..247]
HIS6_THEP3 - Imidazole glycerol phosphate synthase subunit HisF OS=Thermoanaerobacter pseudethanolicus (strain AT... HIS6_THEET - Imidazole glycerol phosphate synthase subunit hisF - Thermoanaerobacter ethanolicus (Clostridium the...	3.0E-74	[3..261]	[5..249]
HIS6_PSEAB - Imidazole glycerol phosphate synthase subunit HisF OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=... HI61_PSEAE, HIS6... - Imidazole glycerol phosphate synthase subunit hisF1 OS=Pseudomonas aeruginosa GN=hisF1 PE=3 SV=1, (Q... HIS61_PSEAE - Imidazole glycerol phosphate synthase subunit hisF1 OS=Pseudomonas aeruginosa (strain ATCC 15692 / P... HIS6_PSEA8 - Imidazole glycerol phosphate synthase subunit HisF OS=Pseudomonas aeruginosa (strain LESB58) GN=hisF... gi\|107104236 - gi\|107104236\|ref\|ZP_01368154.1\| hypothetical protein PaerPA_01005309 [Pseudomonas aeruginosa PACS2] gi\|254238158, gi... - gi\|84317792\|ref\|ZP_00966229.1\| COG0107: Imidazoleglycerol-phosphate synthase [Pseudomonas aeruginosa... gi\|84323776, gi\|... - gi\|84323776\|ref\|ZP_00971843.1\| COG0107: Imidazoleglycerol-phosphate synthase [Pseudomonas aeruginosa...	2.0E-72	[3..261]	[6..252]
HIS6_RALSO - Imidazole glycerol phosphate synthase subunit hisF OS=Ralstonia solanacearum GN=hisF PE=3 SV=1 HIS6_RALSO - Imidazole glycerol phosphate synthase subunit HisF OS=Ralstonia solanacearum (strain GMI1000) GN=his...	3.0E-71	[3..260]	[5..250]
HIS6_CLOAB - Imidazole glycerol phosphate synthase subunit HisF OS=Clostridium acetobutylicum GN=hisF PE=3 SV=1 HIS6_CLOAB - Imidazole glycerol phosphate synthase subunit HisF OS=Clostridium acetobutylicum (strain ATCC 824 / ...	5.0E-71	[3..259]	[5..246]
HIS6_METJA - Imidazole glycerol phosphate synthase subunit HisF OS=Methanocaldococcus jannaschii (strain ATCC 430... HIS6_METJA - Imidazole glycerol phosphate synthase subunit hisF OS=Methanocaldococcus jannaschii GN=hisF PE=3 SV=...	6.0E-71	[3..261]	[5..266]
HIS6_LISIN - Imidazole glycerol phosphate synthase subunit HisF OS=Listeria innocua GN=hisF PE=3 SV=1 HIS6_LISIN - Imidazole glycerol phosphate synthase subunit HisF OS=Listeria innocua serovar 6a (strain CLIP 11262...	2.0E-69	[3..261]	[5..246]
gi\|7437186 - gi\|7437186\|pir\|\|F69045 imidazoleglycerol-phosphate synthase (cyclase) hisF MTH1343 [similarity] - Me... gi\|2622450, gi\|1... - gi\|2622450\|gb\|AAB85821.1\| imidazoleglycerol-phosphate synthase (cyclase) [Methanothermobacter therma...	4.0E-69	[3..261]	[32..296]
HIS6_ARCFU - Imidazole glycerol phosphate synthase subunit HisF OS=Archaeoglobus fulgidus (strain ATCC 49558 / VC... HIS6_ARCFU - Imidazole glycerol phosphate synthase subunit hisF OS=Archaeoglobus fulgidus GN=hisF PE=3 SV=1	5.0E-69	[3..261]	[5..266]

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Predicted Domain #1

Region A:
Residues: [1-261]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKFIGCIDL HNGEVKQIVG GTLTSKKEDV PKTNFVSQHP SSYYAKLYKD RDVQGCHVIK  60
   61 LGPNNDDAAR EALQESPQFL QVGGGINDTN CLEWLKWASK VIVTSWLFTK EGHFQLKRLE 120
  121 RLTELCGKDR IVVDLSCRKT QDGRWIVAMN KWQTLTDLEL NADTFRELRK YTNEFLIHAA 180
  181 DVEGLCGGID ELLVSKLFEW TKDYDDLKIV YAGGAKSVDD LKLVDELSHG KVDLTFGSSL 240
  241 DIFGGNLVKF EDCCRWNEKQ G

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.69897
Match:	1gpwA_
Description:	Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits