YRC Public Data Repository - Protein Structure Prediction

Protein:	STE12
Organism:	Saccharomyces cerevisiae
Length:	688 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STE12.

Description	E-value	Query Range	Subject Range
STE12_YEAST - Protein STE12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STE12 PE=1 SV=1 gi\|151944031 - gi\|151944031\|gb\|EDN62324.1\| transcription factor [Saccharomyces cerevisiae YJM789] STE12 - Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved i... gi\|190405865 - gi\|190405865\|gb\|EDV09132.1\| protein STE12 [Saccharomyces cerevisiae RM11-1a]	0.0	[1..688]	[1..688]
STE12_KLULA - Protein STE12 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-... ST12_KLULA, STE1... - Protein STE12 OS=Kluyveromyces lactis GN=STE12 PE=3 SV=2, (Q08400) STE12 protein	0.0	[9..592]	[7..625]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[14..347]	[1..330]
gi\|619642 - gi\|619642\|gb\|AAA59355.1\| acid proteinase-related protein [Candida albicans]	0.0	[14..347]	[1..330]
gi\|13236844, gi\|... - gi\|32403626\|ref\|XP_322426.1\| hypothetical protein ( (AY027529) Ste12-like transcription factor [Neur... gi\|85087026 - gi\|85087026\|ref\|XP_957811.1\| transcription factor steA [Neurospora crassa OR74A]	3.0E-93	[22..234]	[22..236]
STE12_EMENI - Transcription factor steA OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 19... STE12_EMENI, STE... - (O74252) Transcription factor SteA, Transcription factor steA OS=Emericella nidulans GN=steA PE=2 SV...	1.0E-91	[22..234]	[21..235]
gi\|5802625 - gi\|5802625\|gb\|AAD51741.1\|AF175524_1 Ste12 transcription factor homolog [Clavispora lusitaniae]	6.0E-91	[30..239]	[5..214]
gi\|13398338, gi\|... - gi\|13398338\|gb\|AAK21854.1\|AF284062_1 homeodomain transcription factor StlA [Penicillium marneffei], ...	9.0E-90	[22..235]	[21..235]

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Predicted Domain #1

Region A:
Residues: [1-200]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVQITNSRT EEILKVQANN ENDEVSKATP GEVEESLRLI GDLKFFLATA PVNWQENQII  60
   61 RRYYLNSGQG FVSCVFWNNL YYITGTDIVK CCLYRMQKFG REVVQKKKFE EGIFSDLRNL 120
  121 KCGIDATLEQ PKSEFLSFLF RNMCLKTQKK QKVFFWFSVA HDKLFADALE RDLKRESLNQ 180
  181 PSTTKPVNEP ALSFSYDSSS

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	78.619789
Match:	PF02200
Description:	STE like transcription factor

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [201-688]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKPLYDQLLQ HLDSRRPSST TKSDNSPPKL ESENFKDNEL VTVTNQPLLG VGLMDDDAPE  60
   61 SPSQINDFIP QKLIIEPNTL ELNGLTEETP HDLPKNTAKG RDEEDFPLDY FPVSVEYPTE 120
  121 ENAFDPFPPQ AFTPAAPSMP ISYDNVNERD SMPVNSLLNR YPYQLSVAPT FPVPPSSSRQ 180
  181 HFMTNRDFYS SNNNKEKLVS PSDPTSYMKY DEPVMDFDES RPNENCTNAK SHNSGQQTKQ 240
  241 HQLYSNNFQQ SYPNGMVPGY YPKMPYNPMG GDPLLDQAFY GADDFFFPPE GCDNNMLYPQ 300
  301 TATSWNVLPP QAMQPAPTYV GRPYTPNYRS TPGSAMFPYM QSSNSMQWNT AVSPYSSRAP 360
  361 STTAKNYPPS TFYSQNINQY PRRRTVGMKS SQGNVPTGNK QSVGKSAKIS KPLHIKTSAY 420
  421 QKQYKINLET KARPSAGDED SAHPDKNKEI SMPTPDSNTL VVQSEEGGAH SLEVDTNRRS 480
  481 DKNLPDAT

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits