YRC Public Data Repository - Protein Structure Prediction

Protein:	PPE1
Organism:	Saccharomyces cerevisiae
Length:	400 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPE1.

Description	E-value	Query Range	Subject Range
gi\|151944020 - gi\|151944020\|gb\|EDN62313.1\| YmS2 [Saccharomyces cerevisiae YJM789] PPME1_YEAST - Protein phosphatase methylesterase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PPE... gi\|190405857 - gi\|190405857\|gb\|EDV09124.1\| 40S ribosomal protein YmS2, mitochondrial precursor [Saccharomyces cerev... PPE1 - Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphop...	1.0E-89	[1..400]	[1..400]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	7.0E-52	[83..378]	[2..284]
BPHD_BURCE - 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase OS=Burkholderia cepacia GN=bphD PE=3 SV=1 gi\|18652351 - gi\|18652351\|gb\|AAL77079.1\|AF468021_3 6-substituted 2-hydroxy-6-oxohexa-2,4-dienoate hydrolase [Pseud... gi\|27817718 - gi\|27817718\|emb\|CAD61145.1\| 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase [Cupriavidus oxalatic...	1.0E-51	[83..378]	[2..284]
gi\|4104768 - gi\|4104768\|gb\|AAD02150.1\| hydroxymuconic semialdehyde hydrolase [Pseudomonas stutzeri] gi\|37220708 - gi\|37220708\|gb\|AAQ89678.1\| hydoroxymuconic semialdehyde hydrolase [Pseudomonas putida]	1.0E-51	[88..384]	[4..281]
BPHD_BURCE - (P47229) 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (EC 3.7.1.-) gi\|126031575, gi... - gi\|149243428\|pdb\|2PU5\|B Chain B, Crystal Structure Of A C-C Bond Hydrolase, Bphd, From Burkholderia ... gi\|397886, gi\|484491 - gi\|484491\|pir\|\|JN0816 2,6-dioxo-6-phenylhexa-3-enoate hydrolase (EC 3.7.1.8) - Pseudomonas sp. (stra... BPHD_BURXL - 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase OS=Burkholderia xenovorans (strain LB400) GN=bph...	3.0E-51	[83..379]	[2..285]
BPHD_PSEPS - 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase OS=Pseudomonas pseudoalcaligenes GN=bphD PE=2 SV...	6.0E-51	[83..378]	[2..284]
gi\|6118537 - gi\|6118537\|gb\|AAF04141.1\|AF190707_1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolase [Pseudom...	7.0E-51	[90..378]	[9..284]
gi\|10197684 - gi\|10197684\|gb\|AAG14968.1\|AF233336_1 soluble epoxide hydrolase [Homo sapiens]	8.0E-51	[98..384]	[243..549]
gi\|19033979 - gi\|19033979\|gb\|AAL83662.1\| 2-hydroxymuconic semialdehyde hydrolase [Pseudomonas putida]	9.0E-51	[88..384]	[4..281]

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Predicted Domain #1

Region A:
Residues: [1-89]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDDLRRKIA LSQFERAKNV LDATFQEAYE DDENDGDALG SLPSFNGQSN RNRKYTGKTG  60
   61 STTDRISSKE KSSLPTWSDF FDNKELVSL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.281	a.3.1	Cytochrome c
View	Download	0.281	a.3.1	Cytochrome c
View	Download	0.290	a.11.1	Acyl-CoA binding protein
View	Download	0.261	a.143.1	RNA polymerase omega subunit
View	Download	0.322	d.57.1	DNA damage-inducible protein DinI
View	Download	0.290	a.11.1	Acyl-CoA binding protein
View	Download	0.241	a.163.1	Crustacean CHH/MIH/GIH neurohormone
View	Download	0.261	a.143.1	RNA polymerase omega subunit
View	Download	0.322	d.57.1	DNA damage-inducible protein DinI
View	Download	0.241	a.163.1	Crustacean CHH/MIH/GIH neurohormone
View	Download	0.231	d.58.44	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View	Download	0.228	d.74.3	RBP11-like subunits of RNA polymerase
View	Download	0.210	a.165.1	Myosin phosphatase inhibitor 17kDa protein, CPI-17
View	Download	0.202	d.58.44	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains

Predicted Domain #2

Region A:
Residues: [90-400]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDRDLDVNTY YTLPTSLLSN TTSIPIFIFH HGAGSSGLSF ANLAKELNTK LEGRCGCFAF  60
   61 DARGHAETKF KKADAPICFD RDSFIKDFVS LLNYWFKSKI SQEPLQKVSV ILIGHSLGGS 120
  121 ICTFAYPKLS TELQKKILGI TMLDIVEEAA IMALNKVEHF LQNTPNVFES INDAVDWHVQ 180
  181 HALSRLRSSA EIAIPALFAP LKSGKVVRIT NLKTFSPFWD TWFTDLSHSF VGLPVSKLLI 240
  241 LAGNENLDKE LIVGQMQGKY QLVVFQDSGH FIQEDSPIKT AITLIDFWKR NDSRNVVIKT 300
  301 NWGQHKTVQN T

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.09691
Match:	1cqzA_
Description:	Epoxide hydrolase, N-terminal domain; Mammalian epoxide hydrolase, C-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits