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View Structure Prediction Details

Protein: CIC1
Organism: Saccharomyces cerevisiae
Length: 376 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CIC1.

Description E-value Query
Range
Subject
Range
CIC1_YEAST - Proteasome-interacting protein CIC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CIC1...
gi|151943998 - gi|151943998|gb|EDN62291.1| core interacting component [Saccharomyces cerevisiae YJM789]
CIC1 - Essential protein that interacts with proteasome components and has a potential role in proteasome s...
2.0E-86 [1..376] [1..376]
RK1_CYAPA - 50S ribosomal protein L1, cyanelle OS=Cyanophora paradoxa GN=rpl1 PE=3 SV=1
3.0E-54 [57..299] [2..232]
RL1_DEIRA - 50S ribosomal protein L1 OS=Deinococcus radiodurans GN=rplA PE=1 SV=1
RL1_DEIRA - 50S ribosomal protein L1 OS=Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG...
3.0E-54 [62..291] [6..225]
RL1_THET2 - 50S ribosomal protein L1 OS=Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) GN=rplA PE=...
RL1_THETH - 50S ribosomal protein L1 OS=Thermus thermophilus GN=rplA PE=1 SV=3
gi|2120598 - pir||S66577 ribosomal protein L1 - Thermus aquaticus (fragment)
5.0E-54 [64..291] [9..225]
gi|28373723|pdb|... - Chain d, Structure Of The E. Coli Ribosomal Termination Complex With Release Factor 2
gi|66361020|pdb|... - Chain D, Crystal Structure Of 70s Ribosome With Thrs Operator And Trnas. Large Subunit. The Coordina...
gi|14278034 - gi|14278034|pdb|1GIY|D Chain D, Crystal Structure Of The Ribosome At 5.5 A Resolution. This File, 1g...
gi|28373723 - gi|28373723|pdb|1ML5|DD Chain d, Structure Of The E. Coli Ribosomal Termination Complex With Release...
gi|14278034, gi|... - gi|66361020|pdb|1YL3|D Chain D, Crystal Structure Of 70s Ribosome With Thrs Operator And Trnas. Larg...
6.0E-54 [64..291] [8..224]
gi|9957210 - gi|9957210|gb|AAG09267.1| L1 [EDTA-degrading bacterium BNC1]
5.0E-53 [58..295] [3..228]
RL1_RHIME - 50S ribosomal protein L1 OS=Rhizobium meliloti GN=rplA PE=3 SV=1
RL1_RHIME - 50S ribosomal protein L1 OS=Rhizobium meliloti (strain 1021) GN=rplA PE=3 SV=1
6.0E-53 [58..295] [3..228]
RL1_NOSS1 - 50S ribosomal protein L1 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=rplA PE=3 SV=1
gi|25294935 - pir||AE2468 50S ribosomal protein L1 [imported] - Nostoc sp. (strain PCC 7120)
9.0E-52 [56..294] [2..227]

Back

Predicted Domain #1
Region A:
Residues: [1-130]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKKSNSKKS TPVSTPSKEK KKVIEKKSST AIPRERVIKA VNELIKFTSK PQDENNEEGN  60
   61 NGKKNLLEDD EEELKKDLQL IVVNNKSFTG TSKSFKLKLL NVKHSFYKPW KEASATAVKD 120
  121 FKVLLILKDS 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [219-311]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTTLTNNIKK VYMNQLPVKL PRGTTLNVHL GNLEWLRPEE FVDNVELISE QLIKAYQIRS  60
   61 IFIKTNRSPV LPLYYNQDVL DELEAKKDKI EET

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.69897
Match: 1eg0N_
Description: 70S ribosome functional complex
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [131-218]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DIKKVSEDDL FDQLDSEGIK VDEIICGKDL KTVYKAYEAR NAFISQFSLI LADDSIVTSL  60
   61 PKLMGGKAYN KVETTPISIR THANKEFS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.69897
Match: 1eg0N_
Description: 70S ribosome functional complex
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [312-376]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HEDDMVTIDG VQVHLSTFNK GLMEIANPSE LGSIFSKQIN NAKKRSSSEL EKESSESEAV  60
   61 KKAKS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.454 a.4.1 Homeodomain-like
View Download 0.680 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.458 a.156.1 S13-like H2TH domain
View Download 0.461 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.484 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.451 a.16.1 S15/NS1 RNA-binding domain
View Download 0.444 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.443 a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)
View Download 0.439 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.435 a.21.1 HMG-box
View Download 0.419 a.112.1 Description not found.
View Download 0.417 d.58.1 4Fe-4S ferredoxins
View Download 0.406 a.4.1 Homeodomain-like
View Download 0.398 a.28.2 Colicin E immunity proteins
View Download 0.391 a.101.1 Uteroglobin-like
View Download 0.386 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.374 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.374 a.4.1 Homeodomain-like
View Download 0.365 d.47.1 Ribosomal protein L11, N-terminal domain
View Download 0.336 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.321 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.317 a.4.5 "Winged helix" DNA-binding domain
View Download 0.316 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.311 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.300 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.298 d.15.1 Ubiquitin-like
View Download 0.295 a.5.2 UBA-like
View Download 0.295 a.4.3 ARID-like
View Download 0.290 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.287 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.277 a.4.5 "Winged helix" DNA-binding domain
View Download 0.276 a.16.1 S15/NS1 RNA-binding domain
View Download 0.272 a.4.5 "Winged helix" DNA-binding domain
View Download 0.271 a.65.1 Annexin
View Download 0.264 d.217.1 SAND domain-like
View Download 0.264 a.157.1 Skp1 dimerisation domain-like
View Download 0.260 a.5.6 Hypothetical protein MTH1615
View Download 0.242 a.39.1 EF-hand
View Download 0.241 a.29.2 Bromodomain
View Download 0.236 a.64.1 Saposin
View Download 0.233 a.4.5 "Winged helix" DNA-binding domain
View Download 0.226 a.46.1 Methionine synthase domain
View Download 0.219 a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain
View Download 0.212 a.64.1 Saposin
View Download 0.211 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.210 a.3.1 Cytochrome c
View Download 0.205 a.20.1 PGBD-like
View Download 0.203 a.7.7 BAG domain
View Download 0.201 a.28.1 ACP-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle