YRC Public Data Repository - Protein Structure Prediction

Protein:	COQ6
Organism:	Saccharomyces cerevisiae
Length:	479 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COQ6.

Description	E-value	Query Range	Subject Range
COQ6 - Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes... COQ6_YEAST - Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 2... gi\|190406739 - gi\|190406739\|gb\|EDV10006.1\| monooxygenase [Saccharomyces cerevisiae RM11-1a] gi\|207344914 - gi\|207344914\|gb\|EDZ71899.1\| YGR255Cp-like protein [Saccharomyces cerevisiae AWRI1631]	1.0E-91	[1..479]	[1..479]
coq6 - monooxygenase Coq6 COQ6_SCHPO - Probable ubiquinone biosynthesis monooxygenase coq6 OS=Schizosaccharomyces pombe (strain 972 / ATCC ...	9.0E-67	[25..475]	[22..463]
gi\|17133409, gi\|... - gi\|17231766\|ref\|NP_488314.1\| 2-octaprenyl-6-methoxyphenyl hydroxylase [Nostoc sp. PCC 7120], gi\|1713... gi\|25285745 - pir\|\|AC2340 hypothetical protein ubiH [imported] - Nostoc sp. (strain PCC 7120)	2.0E-66	[17..477]	[13..409]
gi\|170018848, gi... - gi\|170018848\|ref\|YP_001723802.1\| hypothetical protein EcolC_0803 [Escherichia coli ATCC 8739], gi\|16... gi\|169890301, gi... - gi\|170082466\|ref\|YP_001731786.1\| oxidoreductase [Escherichia coli str. K-12 substr. DH10B], gi\|16989... gi\|238902031, gi... - gi\|238902031\|ref\|YP_002927827.1\| putative oxidoreductase with FAD/NAD(P)-binding domain [Escherichia... EG11333 - 2-octaprenylphenol hydroxylase, FAD-dependent / 2-octaprenylphenol hydroxylase, ubiquinone biosynthe... gi\|124502292, gi... - gi\|124526188\|ref\|ZP_01698193.1\| Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family [Esc... gi\|194436863, gi... - gi\|83587698\|ref\|ZP_00926325.1\| COG0654: 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dep... gi\|85675718, gi\|... - gi\|89109685\|ref\|AP_003465.1\| predicted oxidoreductase, FAD/NAD(P)-binding domain [Escherichia coli s... VISC_ECOLI - Protein visC (EC 1.-.-.-) - Escherichia coli EG11333 - 2-octaprenylphenol hydroxylase, FAD-dependent / 2-octaprenylphenol hydroxylase, ubiquinone biosynthe...	9.0E-63	[25..478]	[1..393]
gi\|15680256 - gi\|15680256\|gb\|AAH14483.1\| Coenzyme Q6 homolog, monooxygenase (S. cerevisiae) [Homo sapiens]	1.0E-62	[13..475]	[21..467]
gi\|189377677, gi... - gi\|189377677\|gb\|EDU96093.1\| ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family [Escheri... gi\|195936524 - gi\|195936524\|ref\|ZP_03081906.1\| hypothetical protein EscherichcoliO157_08682 [Escherichia coli O157:... gi\|208805611, gi... - gi\|208805611\|ref\|ZP_03247948.1\| ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family [Esc... gi\|15833031, gi\|... - gi\|15833031\|ref\|NP_311804.1\| hypothetical protein ECs3777 [Escherichia coli O157:H7 str. Sakai], gi\|... gi\|208735692, gi... - gi\|208814415\|ref\|ZP_03255744.1\| ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family [Esc... gi\|168766902, gi... - gi\|189363645\|gb\|EDU82064.1\| ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family [Escheri... gi\|168775786, gi... - gi\|187768774\|gb\|EDU32618.1\| ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family [Escheri... gi\|189003458, gi... - gi\|189003458\|gb\|EDU72444.1\| ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family [Escheri... gi\|189374039, gi... - gi\|189374039\|gb\|EDU92455.1\| ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family [Escheri... gi\|209760470, gi... - pir\|\|E85946 hypothetical protein visC [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|168747612, gi... - gi\|188017922\|gb\|EDU56044.1\| ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family [Escheri... gi\|12517436, gi\|... - gi\|15803441\|ref\|NP_289474.1\| hypothetical protein Z4243 [Escherichia coli O157:H7 EDL933], gi\|125174... gi\|189358665, gi... - gi\|189358665\|gb\|EDU77084.1\| ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family [Escheri... gi\|15833031, gi\|... - gi\|15833031\|ref\|NP_311804.1\| hypothetical protein ECs3777 [Escherichia coli O157:H7], gi\|13363249\|db... gi\|189369394, gi... - gi\|189369394\|gb\|EDU87810.1\| ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family [Escheri... gi\|208740853, gi... - gi\|208820730\|ref\|ZP_03261050.1\| ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family [Esc... gi\|209397458, gi... - gi\|209397458\|ref\|YP_002272382.1\| ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family [Es... gi\|217327872, gi... - gi\|217327872\|ref\|ZP_03443955.1\| ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family [Esc... gi\|254794855, gi... - gi\|254794855\|ref\|YP_003079692.1\| predicted oxidoreductase with FAD/NAD(P)-binding domain [Escherichi...	2.0E-62	[25..478]	[1..393]
gi\|170018848, gi... - gi\|170018848\|ref\|YP_001723802.1\| hypothetical protein EcolC_0803 [Escherichia coli ATCC 8739], gi\|16... gi\|169890301, gi... - gi\|170082466\|ref\|YP_001731786.1\| oxidoreductase [Escherichia coli str. K-12 substr. DH10B], gi\|16989... gi\|238902031, gi... - gi\|238902031\|ref\|YP_002927827.1\| putative oxidoreductase with FAD/NAD(P)-binding domain [Escherichia... EG11333 - 2-octaprenylphenol hydroxylase, FAD-dependent / 2-octaprenylphenol hydroxylase, ubiquinone biosynthe... gi\|124502292, gi... - gi\|124526188\|ref\|ZP_01698193.1\| Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family [Esc... gi\|194436863, gi... - gi\|83587698\|ref\|ZP_00926325.1\| COG0654: 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dep... gi\|85675718, gi\|... - gi\|89109685\|ref\|AP_003465.1\| predicted oxidoreductase, FAD/NAD(P)-binding domain [Escherichia coli s... VISC_ECOLI - Protein visC (EC 1.-.-.-) - Escherichia coli EG11333 - 2-octaprenylphenol hydroxylase, FAD-dependent / 2-octaprenylphenol hydroxylase, ubiquinone biosynthe...	4.0E-62	[25..478]	[1..393]
gi\|18848355 - gi\|18848355\|gb\|AAH24135.1\| Coq6 protein [Mus musculus]	1.0E-61	[13..475]	[23..469]
gi\|15602867, gi\|... - gi\|15602867\|ref\|NP_245939.1\| hypothetical protein PM1002 [Pasteurella multocida subsp. multocida str...	4.0E-61	[29..477]	[7..391]
gi\|121590998, gi... - gi\|121590998\|ref\|ZP_01678317.1\| visC protein [Vibrio cholerae 2740-80], gi\|121547175\|gb\|EAX57304.1\| ... gi\|153222471, gi... - gi\|153222471\|ref\|ZP_01953205.1\| visC protein [Vibrio cholerae MAK 757], gi\|124118908\|gb\|EAY37651.1\| ... gi\|153820350, gi... - gi\|153820350\|ref\|ZP_01973017.1\| visC protein [Vibrio cholerae NCTC 8457], gi\|126509106\|gb\|EAZ71700.1... gi\|227010483, gi... - gi\|227082595\|ref\|YP_002811146.1\| visC protein [Vibrio cholerae M66-2], gi\|227010483\|gb\|ACP06695.1\| v... gi\|15642470, gi\|... - gi\|9657053\|gb\|AAF95616.1\| visC protein [Vibrio cholerae O1 biovar El Tor str. N16961], gi\|15642470\|r... gi\|75829334, gi\|... - gi\|75829334\|ref\|ZP_00758641.1\| COG0654: 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dep... gi\|229507467, gi... - gi\|229507467\|ref\|ZP_04396972.1\| 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase [Vibrio ... gi\|11255980 - pir\|\|D82071 visC protein VC2474 [imported] - Vibrio cholerae (strain N16961 serogroup O1) gi\|227118916, gi... - gi\|75827737\|ref\|ZP_00757172.1\| COG0654: 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dep... gi\|229512338, gi... - gi\|229512338\|ref\|ZP_04401817.1\| 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase [Vibrio ... gi\|121729910, gi... - gi\|75814526\|ref\|ZP_00745103.1\| COG0654: 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dep... gi\|229519474, gi... - gi\|229519474\|ref\|ZP_04408917.1\| 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase [Vibrio ... gi\|229369627, gi... - gi\|229606972\|ref\|YP_002877620.1\| 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase [Vibrio...	5.0E-61	[25..477]	[2..392]

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Predicted Domain #1

Region A: Residues: [1-110]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MFFSKVMLTR RILVRGLATA KSSAPKLTDV LIVGGGPAGL TLAASIKNSP QLKDLKTTLV 60 61 DMVDLKDKLS DFYNSPPDYF TNRIVSVTPR SIHFLENNAG ATLMHDRIQS [Run NCBI BLAST on this sequence.]
Region B: Residues: [133-244]	1 11 21 31 41 51 \| \| \| \| \| \| 1 LCMIEIINIQ ASLYNRISQY DSKKDSIDII DNTKVVNIKH SDPNDPLSWP LVTLSNGEVY 60 61 KTRLLVGADG FNSPTRRFSQ IPSRGWMYNA YGVVASMKLE YPPFKLRGWQ RF [Run NCBI BLAST on this sequence.]
Region C: Residues: [356-426]	1 11 21 31 41 51 \| \| \| \| \| \| 1 LKLTHADRYC TDRVALVGDA AHTTHPLAGQ GLNMGQTDVH GLVYALEKAM ERGLDIGSSL 60 61 SLEPFWAERY P [Run NCBI BLAST on this sequence.]
Region D: Residues: [472-479]	1 11 21 31 41 51 \| \| \| \| \| \| 1 DTLGGNEK [Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.522879
Match:	1k0iA_
Description:	p-Hydroxybenzoate hydroxylase, PHBH; p-Hydroxybenzoate hydroxylase (PHBH)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on NADH or NADPH	1.94752631746117	bayes_pls_golite062009
oxidoreductase activity	1.52511707514198	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	1.45104542724719	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.18990628739838	bayes_pls_golite062009
antioxidant activity	1.12347155061135	bayes_pls_golite062009
catalytic activity	1.03127962968326	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	0.876978863121464	bayes_pls_golite062009
binding	0.850689563354756	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors	0.643810447309487	bayes_pls_golite062009
protein binding	0.370064403093958	bayes_pls_golite062009
NADPH-adrenodoxin reductase activity	0.23045510393832	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	0.130601418359425	bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity	0.0438965603843511	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [111-132]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDGLYVTDGC SKATLDLARD SM

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [245-355]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPTGPIAHLP MPENNATLVW SSSERLSRLL LSLPPESFTA LINAAFVLED ADMNYYYRTL  60
   61 EDGSMDTDKL IEDIKFRTEE IYATLKDESD IDEIYPPRVV SIIDKTRARF P

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [427-471]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNNVLLGMAD KLFKLYHTNF PPVVALRTFG LNLTNKIGPV KNMII

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.522879
Match:	1k0iA_
Description:	p-Hydroxybenzoate hydroxylase, PHBH; p-Hydroxybenzoate hydroxylase (PHBH)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: