YRC Public Data Repository - Protein Structure Prediction

Protein:	PUP2
Organism:	Saccharomyces cerevisiae
Length:	260 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PUP2.

Description	E-value	Query Range	Subject Range
gi\|190406741 - gi\|190406741\|gb\|EDV10008.1\| proteasome subunit [Saccharomyces cerevisiae RM11-1a] PSA5_YEAST - Proteasome subunit alpha type-5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PUP2 PE=... gi\|151943527 - gi\|151943527\|gb\|EDN61838.1\| proteasome subunit [Saccharomyces cerevisiae YJM789] PUP2 - Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is s...	1.0E-84	[1..260]	[1..260]
gi\|286250 - gi\|286250\|dbj\|BAA01587.1\| proteasome subunit R-IOTA [Rattus sp.] gi\|67969980 - gi\|67969980\|dbj\|BAE01337.1\| unnamed protein product [Macaca fascicularis] PSMA6 - proteasome (prosome, macropain) subunit, alpha type, 6 PSA6_BOVIN - Proteasome subunit alpha type-6 OS=Bos taurus GN=PSMA6 PE=1 SV=1 gi\|55640605, gi\|... - gi\|55640605\|ref\|XP_509906.1\| PREDICTED: proteasome alpha 6 subunit isoform 6 [Pan troglodytes], gi\|1... gi\|109083327, gi... - gi\|109083327\|ref\|XP_001086524.1\| PREDICTED: similar to Proteasome subunit alpha type 6 (Proteasome i... gi\|149692835 - gi\|149692835\|ref\|XP_001491320.1\| PREDICTED: similar to proteasome alpha 6 subunit [Equus caballus] ENSOCUP000000134... - pep:novel chromosome:oryCun2:17:55028440:55047757:1 gene:ENSOCUG00000015635 transcript:ENSOCUT000000... PSA6_RAT - Proteasome subunit alpha type-6 OS=Rattus norvegicus GN=Psma6 PE=1 SV=1 gi\|123983062 - gi\|123983062\|gb\|ABM83272.1\| proteasome (prosome, macropain) subunit, alpha type, 6 [synthetic constr... gi\|222154129 - gi\|222154129\|gb\|ACM47241.1\| proteasome subunit alpha type 6 [Capra hircus] tr\|M3WV20\|M3WV20... - Proteasome subunit alpha type OS=Felis catus GN=PSMA6 PE=3 SV=1	1.0E-81	[4..247]	[5..246]
PSA5_SCHPO - Probable proteasome subunit alpha type-5 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=p... SPAC323.02c - 20S proteasome component alpha 5	1.0E-81	[1..246]	[1..245]
PSA6_MOUSE - Proteasome subunit alpha type-6 OS=Mus musculus GN=Psma6 PE=1 SV=1	6.0E-81	[4..247]	[5..246]
gi\|218186097 - gi\|218186097\|gb\|EEC68524.1\| hypothetical protein OsI_36813 [Oryza sativa Indica Group] PSA5_ORYSJ - Proteasome subunit alpha type-5 OS=Oryza sativa subsp. japonica GN=PAE1 PE=2 SV=1 PSA5_ORYSA - Proteasome subunit alpha type 5 (EC 3.4.25.1) (20S proteasome alpha subunit E) (20S proteasome subun...	5.0E-80	[1..243]	[1..237]
PSA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=psmA PE=3 SV=1 PSMA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi GN=psmA PE=3 SV=1	6.0E-80	[5..240]	[7..234]
gi\|71746456 - gi\|71746456\|ref\|XP_822283.1\| proteasome subunit alpha 5 [Trypanosoma brucei TREU927] gi\|70831951 - gi\|70831951\|gb\|EAN77455.1\| proteasome alpha 5 subunit, putative [Trypanosoma brucei] PSA5_TRYBB - Proteasome subunit alpha type-5 OS=Trypanosoma brucei brucei PE=3 SV=1	7.0E-80	[1..246]	[1..245]
PSA5A_ARATH - Proteasome subunit alpha type-5-A OS=Arabidopsis thaliana GN=PAE1 PE=1 SV=1	3.0E-79	[1..243]	[1..237]
PSA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC ... PSMA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii GN=psmA PE=3 SV=1	3.0E-79	[5..240]	[7..234]

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Predicted Domain #1

Region A:
Residues: [1-260]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFLTRSEYDR GVSTFSPEGR LFQVEYSLEA IKLGSTAIGI ATKEGVVLGV EKRATSPLLE  60
   61 SDSIEKIVEI DRHIGCAMSG LTADARSMIE HARTAAVTHN LYYDEDINVE SLTQSVCDLA 120
  121 LRFGEGASGE ERLMSRPFGV ALLIAGHDAD DGYQLFHAEP SGTFYRYNAK AIGSGSEGAQ 180
  181 AELLNEWHSS LTLKEAELLV LKILKQVMEE KLDENNAQLS CITKQDGFKI YDNEKTAELI 240
  241 KELKEKEAAE SPEEADVEMS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1455.39794
Match:	1fntE_
Description:	CRYSTAL STRUCTURE OF THE 20S PROTEASOME FROM YEAST IN COMPLEX WITH THE PROTEASOME ACTIVATOR PA26 FROM TRYPANOSOME BRUCEI AT 3.2 ANGSTROMS RESOLUTION
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits