YRC Public Data Repository - Protein Structure Prediction

Protein:	ADE6
Organism:	Saccharomyces cerevisiae
Length:	1358 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADE6.

Description	E-value	Query Range	Subject Range
gi\|557020 - gi\|557020\|gb\|AAA50357.1\| formylglycinamide ribonucleotide synthetase	0.0	[1..1358]	[1..1360]
PUR4_RALSO - Phosphoribosylformylglycinamidine synthase OS=Ralstonia solanacearum (strain GMI1000) GN=purL PE=3 S... PUR4_RALSO - Phosphoribosylformylglycinamidine synthase OS=Ralstonia solanacearum GN=purL PE=3 SV=1	0.0	[6..1358]	[7..1369]
PUR4_SALTI - Phosphoribosylformylglycinamidine synthase OS=Salmonella typhi GN=purL PE=3 SV=3 gi\|16761478 - gi\|16761478\|ref\|NP_457095.1\| phosphoribosylformylglycinamidine synthase [Salmonella enterica subsp. ... PUR4_SALTI - Phosphoribosylformylglycinamidine synthase OS=Salmonella typhi GN=purL PE=3 SV=3 gi\|214000682 - gi\|214000682\|ref\|ZP_03411417.1\| phosphoribosylformylglycinamidine synthase [Salmonella enterica subs...	0.0	[5..1358]	[4..1295]
gi\|18071664 - gi\|18071664\|gb\|AAL55431.1\| formylglycinamide ribonucleotide amidotransferase [Vigna unguiculata]	0.0	[39..1356]	[2..1287]
PUR4_SCHPO - Probable phosphoribosylformylglycinamidine synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC ... ade3 - phosphoribosylformylglycinamidine synthase Ade3	0.0	[51..1358]	[20..1323]
gi\|125619740, gi... - gi\|75831918\|ref\|ZP_00761177.1\| COG0046: Phosphoribosylformylglycinamidine (FGAM) synthase, synthetas... gi\|146315234, gi... - gi\|75826192\|ref\|ZP_00755627.1\| COG0046: Phosphoribosylformylglycinamidine (FGAM) synthase, synthetas... PUR4_VIBCH - Phosphoribosylformylglycinamidine synthase OS=Vibrio cholerae GN=purL PE=3 SV=1 gi\|121550061, gi... - gi\|121585698\|ref\|ZP_01675493.1\| phosphoribosylformylglycinamidine synthase [Vibrio cholerae 2740-80]... gi\|229371197, gi... - gi\|229608542\|ref\|YP_002879190.1\| phosphoribosylformylglycinamidine synthase synthetase subunit/phosp... gi\|124117863, gi... - gi\|153224103\|ref\|ZP_01954227.1\| phosphoribosylformylglycinamidine synthase [Vibrio cholerae MAK 757]... gi\|229517927, gi... - gi\|229517927\|ref\|ZP_04407371.1\| phosphoribosylformylglycinamidine synthase synthetase subunit/phosph... PUR4_VIBCH - Phosphoribosylformylglycinamidine synthase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El To... gi\|153819005, gi... - gi\|153819005\|ref\|ZP_01971672.1\| phosphoribosylformylglycinamidine synthase [Vibrio cholerae NCTC 845... gi\|229357746, gi... - gi\|229505523\|ref\|ZP_04395033.1\| phosphoribosylformylglycinamidine synthase synthetase subunit/phosph... gi\|229510807, gi... - gi\|229510807\|ref\|ZP_04400286.1\| phosphoribosylformylglycinamidine synthase synthetase subunit/phosph... gi\|227081045, gi... - gi\|227081045\|ref\|YP_002809596.1\| phosphoribosylformylglycinamidine synthase [Vibrio cholerae M66-2],...	0.0	[5..1358]	[3..1297]
gi\|12516970, gi\|... - gi\|15803082\|ref\|NP_289113.1\| phosphoribosylformylglycinamidine synthase [Escherichia coli O157:H7 ED... gi\|25293858 - gi\|25293858\|pir\|\|C85901 hypothetical protein purL [imported] - Escherichia coli (strain O157:H7, su...	0.0	[5..1358]	[4..1295]
PUR4_PSEAE - Phosphoribosylformylglycinamidine synthase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C ... PUR4_PSEAE - Phosphoribosylformylglycinamidine synthase OS=Pseudomonas aeruginosa GN=purL PE=3 SV=1	0.0	[5..1357]	[3..1297]
EG10797 - phosphoribosylformyl-glycineamide synthetase / Phosphoribosylformylglycinamide synthase; contains a ... gi\|169890002, gi... - gi\|170082167\|ref\|YP_001731487.1\| phosphoribosylformyl-glycineamide synthetase [Escherichia coli str.... gi\|238862060, gi... - gi\|238901722\|ref\|YP_002927518.1\| phosphoribosylformyl-glycineamide synthetase [Escherichia coli BW29... PUR4_ECOLI - (P15254) Phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) (FGAM synthase) (FGAMS) (Formylglyc... gi\|85675448, gi\|... - gi\|89109363\|ref\|AP_003143.1\| phosphoribosylformyl-glycineamide synthetase [Escherichia coli str. K-1... EG10797 - phosphoribosylformyl-glycineamide synthetase / Phosphoribosylformylglycinamide synthase; contains a ...	0.0	[5..1358]	[4..1295]
gi\|1074100 - gi\|1074100\|pir\|\|H64090 phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) - Haemophilus influen... gi\|16272693, gi\|... - gi\|16272693\|ref\|NP_438911.1\| phosphoribosylformylglycinamidine synthase [Haemophilus influenzae Rd K...	0.0	[1..1355]	[24..1318]

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Predicted Domain #1

Region A:
Residues: [1-251]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDYILPGPK ALSQFRVDNL IKDINSYTNS TSVINELRSC YIHYVNGIAQ NLSEQDTKLL  60
   61 EVLLTYDSAL DIANDPLARQ LNDAVANNLP SSALGEDTYL IRVVPRSGTI SPWSSKATNI 120
  121 AHVCGLQDKV QRIERGLALL IKTVPGFPLL ENLNDISLKC VYDRMTQQLY LTEPPNTMSI 180
  181 FTHEEPKPLV HVPLTPKDTK QSPKDILSKA NTELGLALDS GEMEYLIHAF VETMKRDPTD 240
  241 VELFMFAQVN S

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
phosphoribosylformylglycinamidine synthase activity	3.63602541423478	bayes_pls_golite062009
phosphoribosylformylglycinamidine cyclo-ligase activity	3.04322905277855	bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	2.83262699406158	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	2.47010130088456	bayes_pls_golite062009
cyclo-ligase activity	2.40623349460413	bayes_pls_golite062009
carbamoyl-phosphate synthase activity	1.74828881793189	bayes_pls_golite062009
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	1.74029540439985	bayes_pls_golite062009
binding	1.31749052462602	bayes_pls_golite062009
catalytic activity	1.23634637968745	bayes_pls_golite062009
ligase activity	1.09859780971947	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	0.78656048097577	bayes_pls_golite062009
protein binding	0.288540446972424	bayes_pls_golite062009
nucleic acid binding	0.12569720972861	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [252-463]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EHCRHKIFNA DWTIDGIKQQ FTLFQMIRNT HKLNPEYTIS AYSDNAAVLD SENDAFFFAP  60
   61 NSTTKEWTST KERIPLLIKV ETHNHPTAVS PFPGAATGSG GEIRDEGATG RGSKTKCGLS 120
  121 GFSVSDLLIP GNEQPWELNI GKPYHIASAL DIMIEAPLGS AAFNNEFGRP CINGYFRTLT 180
  181 TKVLNHQGKE EIRGFHKPIM IAGGFGTVRP QF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	66.39794
Match:	1cliA_
Description:	Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain; Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [464-484]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALKNTPITPG SCLIVLGGQS M

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [527-655]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ACVALGNNNP IQSIHDVGAG GLSNALPELV HDNDLGAKFD IRKVLSLEPG MSPMEIWCNE  60
   61 SQERYVLGVS PQDLSIFEEI CKRERAPFAV VGHATAEQKL IVEDPLLKTT PIDLEMPILF 120
  121 GKPPKMSRE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	66.39794
Match:	1cliA_
Description:	Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain; Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [485-526]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIGLGGGAAS SVASGEGSAD LDFASVQRGN PEMERRCQQV ID

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	66.39794
Match:	1cliA_
Description:	Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain; Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [656-1062]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TITEALNLPE ANLSEIPSLQ DAIQRVLNLP SVGSKSFLIT IGDRSVTGLI DRDQFVGPWQ  60
   61 VPVADVGVTG TSLGETIIST GEAMAMGEKP VNALISASAS AKLSVAESLL NIFAADVKSL 120
  121 NHIKLSANWM SPASHQGEGS KLYEAVQALG LDLCPALGVA IPVGKDSMSM KMKWDDKEVT 180
  181 APLSLNITAF APVFNTSKTW TPLLNRNTDD SVLVLVDLSA KQETKSLGAS ALLQVYNQVG 240
  241 NKSPTVYDNA ILKGFLESLI QLHQQKEDIV LAYHDRSDGG LLITLLEMAF ASRCGLEINI 300
  301 DGGDLESQLT NLFNEELGAV FQISAKNLSK FEKILNENGV AKEYISIVGK PSFQSQEIKI 360
  361 INSTTNDVIY ANSRSELEQT WSKTSYEMQK LRDNPKTAEE EFASITD

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [1063-1358]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRDPGLQYAL TYNPADDMKI GLELSSQRPK VAILREQGVN GQMEMAWCFQ QAGFNSVDVT  60
   61 MTDLLEGRFH LDDFIGLAAC GGFSYGDVLG AGAGWAKSVL YHEGVRSQFS KFFNERQDTF 120
  121 AFGACNGCQF LSRLKDIIPG CENWPSFERN VSEQYEARVC MVQISQEKDN SSEESVFLNG 180
  181 MAGSKLPIAV AHGEGKATFS KSAEQLEKFE KDGLCCIRYV DNYGNVTERF PFNPNGSTNG 240
  241 IAGIKSPNGR VLAMMPHPER VCRLEANSWY PEGKYEEWGG YGPWIRLFRS ARRWVG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.69897
Match:	1jvnA_
Description:	Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF; GAT subunit, HisH, (or domain) of imidazoleglycerolphosphate synthase HisF
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: