YRC Public Data Repository - Protein Structure Prediction

Protein:	YGR015C
Organism:	Saccharomyces cerevisiae
Length:	328 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YGR015C.

Description	E-value	Query Range	Subject Range
HYES_MOUSE - Bifunctional epoxide hydrolase 2 OS=Mus musculus GN=Ephx2 PE=1 SV=2	2.0E-52	[16..323]	[233..544]
gi\|15230018, gi\|... - gi\|6714450\|gb\|AAF26137.1\|AC011620_13 putative epoxide hydrolase [Arabidopsis thaliana], gi\|21436463\|...	2.0E-52	[15..322]	[1..323]
gi\|10197684 - gi\|10197684\|gb\|AAG14968.1\|AF233336_1 soluble epoxide hydrolase [Homo sapiens]	1.0E-51	[17..320]	[236..543]
HYES_RAT - Bifunctional epoxide hydrolase 2 OS=Rattus norvegicus GN=Ephx2 PE=1 SV=1	2.0E-51	[16..323]	[233..544]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	6.0E-50	[15..322]	[1..320]

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Predicted Domain #1

Region A:
Residues: [1-328]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRLAHNKAL PYKIIVDLSF HRTRLPSDVS SLIKFEQRPA IINIHGLLGS HVMFHSLNKL  60
   61 LSRKLDADIF SVDVRNHGIS PKAIPYDYTT LTNDLIYFIE THIGLERPIY LLGFSMGGKI 120
  121 ALLTTLYKNI NIRKCISIDL PPYETPELDP MILQNYDLIM RIIRRDVKIL RGSPSWQKKV 180
  181 LELFKSLECN KRKCGGAVAL YFANGFLSVK SNNVHQAQLH YEQQQHDPYI NYSMPLSSMP 240
  241 NLLDEVKKWP DLSNQRDFFQ KGTASRKVLF MKGLQSNFIN NDYSLLRYNF PCADVREFNT 300
  301 GHNLLLENPE DSFKCILNFF AEETLDFE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.154902
Match:	1cqzA_
Description:	Epoxide hydrolase, N-terminal domain; Mammalian epoxide hydrolase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.39629727416851	bayes_pls_golite062009
hydrolase activity	0.804811554417903	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.198165097555003	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: